ChemicalBook > CAS DataBase List > 2-Chloro-5-nitro-benzenesulfonyl chloride

2-Chloro-5-nitro-benzenesulfonyl chloride

Product Name
2-Chloro-5-nitro-benzenesulfonyl chloride
CAS No.
4533-95-3
Chemical Name
2-Chloro-5-nitro-benzenesulfonyl chloride
Synonyms
NSC 350627;2-Chlor-5-nitrobenzolsulfonylchlorid;2-Chloro-5-nitro-benzenesulfonyl chloride;2-chloro-5-nitrobenzenesulphonyl chloride;2-chloro-5-nitrobenzene-1-sulfonyl chloride;Benzenesulfonyl chloride, 2-chloro-5-nitro-;2-chloro-5-nitrobenzene-1-sulphonyl chloride;tianfu-chem-2-Chloro-5-nitro-benzenesulfonyl chloride,4533-95-3
CBNumber
CB5648603
Molecular Formula
C6H3Cl2NO4S
Formula Weight
256.06
MOL File
4533-95-3.mol
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2-Chloro-5-nitro-benzenesulfonyl chloride Property

Melting point:
88-90°C
Boiling point:
371.6±32.0 °C(Predicted)
Density 
1.708±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,2-8°C
solubility 
Dichloromethane, Ether, Ethyl Acetate
form 
Solid
color 
Off-White to Pale Yellow
CAS DataBase Reference
4533-95-3(CAS DataBase Reference)
EPA Substance Registry System
Benzenesulfonyl chloride, 2-chloro-5-nitro- (4533-95-3)
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Safety

RIDADR 
UN3261
HazardClass 
8
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
R702137
Product name
2-CHLORO-5-NITROBENZENESULFONYL CHLORIDE
Purity
Aldrich<sup>CPR</sup>
Packaging
1 unit
Price
$30.7
Updated
2025/07/31
Sigma-Aldrich
Product number
R702137
Product name
2-CHLORO-5-NITROBENZENESULFONYL CHLORIDE
Purity
AldrichCPR
Packaging
5mg
Price
$29.8
Updated
2024/03/01
TRC
Product number
C373885
Product name
2-CHLORO-5-NITROBENZENESULFONYL CHLORIDE
Packaging
5g
Price
$415
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC00933
Product name
2-Chloro-5-nitrobenzene sulfonyl chloride
Packaging
5G
Price
$450
Updated
2021/12/16
AK Scientific
Product number
V0500
Product name
2-CHLORO-5-NITROBENZENESULFONYL CHLORIDE
Packaging
10g
Price
$497
Updated
2021/12/16
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2-Chloro-5-nitro-benzenesulfonyl chloride Chemical Properties,Usage,Production

Chemical Properties

Solid

Uses

2-Chloro-5-nitrobenzenesulfonyl Chloride (cas# 4533-95-3) is a compound useful in organic synthesis.

Synthesis

6283-25-6

4533-95-3

General procedure for the synthesis of 2-chloro-5-nitrobenzenesulfonyl chloride from 2-chloro-5-nitroaniline: 2-chloro-5-nitrobenzene-1-sulfonyl chloride (37) was prepared as shown in Scheme 5. First, 2-chloro-5-nitroaniline (10 g) was added in batches to hydrochloric acid (100 mL) cooled in an ice bath until complete dissolution. Subsequently, an aqueous sodium nitrite solution (6.0 g, dissolved in 50 mL of water) was added dropwise and the reaction mixture was stirred at 0 °C for 1 hour. Next, the resulting diazonium ion solution was slowly added to acetic acid (500 mL) pre-saturated with sulfur dioxide gas, which contained ice bath cooled copper chloride dihydrate (5 g). The reaction mixture was continued to be stirred at 0°C for 1 hr and then carefully added to the ice-water slurry in batches while maintaining vigorous stirring. The precipitated solid was collected by filtration, washed with water and dried under vacuum to afford the target product 37 as a cream colored powder (8.2 g, 55% yield). The product was characterized by 1H NMR (500 MHz, DMSO-d6): δ 8.61 (d, J=3Hz, 1H), 8.16 (dd, J1=9Hz, J2=3Hz, 1H), 7.70 (d, J=9Hz, 1H).

References

[1] Patent: WO2010/123960, 2010, A2. Location in patent: Page/Page column 104-105
[2] Patent: WO2010/123956, 2010, A2. Location in patent: Page/Page column 106-107
[3] Journal of Organic Chemistry USSR (English Translation), 1968, vol. 4, p. 478 - 481
[4] Zhurnal Organicheskoi Khimii, 1968, vol. 4, # 3, p. 490 - 493
[5] Journal of Pharmacy and Pharmacology, 2001, vol. 53, # 5, p. 669 - 680

2-Chloro-5-nitro-benzenesulfonyl chloride Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Chloro-5-nitro-benzenesulfonyl chloride Suppliers

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View Lastest Price from 2-Chloro-5-nitro-benzenesulfonyl chloride manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
2-Chloro-5-nitro-benzenesulfonyl chloride 4533-95-3
Price
US $25.00-11.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200000KG
Release date
2024-08-12
Career Henan Chemical Co
Product
2-Chloro-5-nitro-benzenesulfonyl chloride 4533-95-3
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2019-07-11

4533-95-3, 2-Chloro-5-nitro-benzenesulfonyl chlorideRelated Search:

N-Acetylsulfanilyl chloride 2-Chloro-5-nitrobenzoic acid Benzenesulfonyl chloride 2-Nitrobenzenesulfenyl chloride 2-Chloro-5-nitrophenol 4-Fluorobenzenesulfonyl chloride 4-Nitrobenzenesulfonyl chloride 2-Nitrobenzenesulfonyl chloride Difluorochloromethane 3-Nitrobenzenesulfonyl chloride NITROGEN DIOXIDE 4-Chloro-3-nitrobenzenesulfonyl chloride 3-CHLORO-4-NITROBENZENESULFONYL CHLORIDE 2-Chlorobenzenesulfonyl chloride 2-Chloro-5-nitro-benzenesulfonyl chloride 2-CHLORO-4-NITRO-BENZENESULFONYL CHLORIDE 2-chloro-4-fluoro-5-nitrobenzenesulfonyl chloride

  • 2-chloro-5-nitrobenzenesulphonyl chloride
  • 2-Chlor-5-nitrobenzolsulfonylchlorid
  • 2-Chloro-5-nitro-benzenesulfonyl chloride
  • 2-chloro-5-nitrobenzene-1-sulfonyl chloride
  • NSC 350627
  • 2-chloro-5-nitrobenzene-1-sulphonyl chloride
  • Benzenesulfonyl chloride, 2-chloro-5-nitro-
  • tianfu-chem-2-Chloro-5-nitro-benzenesulfonyl chloride,4533-95-3
  • 4533-95-3
  • C6H3ClNO4S
  • C6H3NO4Cl2S
  • Sulfonyl Chlorides
  • Benzene derivates