Ethyl 2-methylnicotinate
- Product Name
- Ethyl 2-methylnicotinate
- CAS No.
- 1721-26-2
- Chemical Name
- Ethyl 2-methylnicotinate
- Synonyms
- 2-methylnicotin ethyl ester;Ethyl 2-methylnicotite;ETHYL 2-METHYLNICOTINATE;ethyle2-methylnicotinate;Ethyl 2-methylinicotinate;Ethyl2-Methylnicotinate>Ethyl2-methylnicotinate,97%;Ethyl 2-methylnicotinate 98%;2-METHYLNICOTINIC ACID ETHYL ESTER;ethyl 2-methylpyridine-3-carboxylate
- CBNumber
- CB5663967
- Molecular Formula
- C9H11NO2
- Formula Weight
- 165.19
- MOL File
- 1721-26-2.mol
Ethyl 2-methylnicotinate Property
- Melting point:
- 146-147 °C
- Boiling point:
- 126-127 °C24 mm Hg(lit.)
- Density
- 1.072 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.505(lit.)
- Flash point:
- 217 °F
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 4.02±0.10(Predicted)
- form
- Liquid
- color
- Clear colorless to orange
- Water Solubility
- Slightly soluble in water.
- λmax
- 268nm(EtOH)(lit.)
- BRN
- 118200
- InChI
- InChI=1S/C9H11NO2/c1-3-12-9(11)8-5-4-6-10-7(8)2/h4-6H,3H2,1-2H3
- InChIKey
- TZORNSWZUZDUCU-UHFFFAOYSA-N
- SMILES
- C1(C)=NC=CC=C1C(OCC)=O
- CAS DataBase Reference
- 1721-26-2(CAS DataBase Reference)
- NIST Chemistry Reference
- Ethyl 2-methylnicotinate(1721-26-2)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 325201
- Product name
- Ethyl 2-methylpyridine-3-carboxylate
- Purity
- 97%
- Packaging
- 5g
- Price
- $89.5
- Updated
- 2023/06/20
- Product number
- E0860
- Product name
- Ethyl 2-Methylnicotinate
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $54
- Updated
- 2025/07/31
- Product number
- E0860
- Product name
- Ethyl 2-Methylnicotinate
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $193
- Updated
- 2024/03/01
- Product number
- E926693
- Product name
- Ethyl 2-Methylnicotinate
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- JK103929
- Product name
- Ethyl 2-methylpyridine-3-carboxylate
- Purity
- 98%
- Packaging
- 5g
- Price
- $67
- Updated
- 2021/12/16
Ethyl 2-methylnicotinate Chemical Properties,Usage,Production
Chemical Properties
Colorless liquid
Uses
Ethyl 2-methylpyridine-3-carboxylate was used in the preparation of amino esters such as ethyl 2(piperidinylaminomethyl)benzoate, ethyl 2-(N-benzyl-N-methylaminomethyl)benzoate, ethyl 2-(diethylaminomethyl)benzoate.
Synthesis
A method for the preparation of Ethyl 2-methylnicotinate, as follows:
(1) 2.0 mol of 1,1,3,3-tetramethoxypropane was added into a reactor at room temperature, 2.5 mol of hydrochloric acid at a mass concentration of 20% was added with stirring, and the reaction was carried out at a controlled temperature of 40 C. for 4 hours; the 2.5 mol refers to the molar amount of HCl in the hydrochloric acid, and the following is the same;
( 2) adding 1 mol of -aminocrotonic acid methyl ester, 6 mol of methanol to the reactor, controlling the reaction temperature at 50C, and reacting for 6 hours;
wherein the molar ratio of -aminocrotonic acid methyl ester, 1,1,3,3-tetramethoxypropane, hydrochloric acid, and methanol was 1.0:2.0:2.5:6.0;
(3) reducing pressure and concentrating the above reaction solution (3)Concentrate the above reaction solution under reduced pressure, neutralize the concentrated solution with 10% aqueous sodium hydroxide solution to the system pH=5.0, add 5 times the mass of -aminocrotonic acid methyl ester of ethyl acetate to the system, extract the fractional phase, add 4 times the mass of -aminocrotonic acid methyl ester of water to the organic phase, wash the fractional phase, concentrate the organic phase, and then continue to distil with a small rotary-vane vacuum pump to collect the fractions, to obtain the liquid of 2-methyl nicotinic acid methyl ester 105.9 g , with a yield of 70.1% and a purity of 98.45%.
Ethyl 2-methylnicotinate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ethyl 2-methylnicotinate manufacturers
- Product
- Ethyl 2-methylnicotinate 1721-26-2
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-25
- Product
- Ethyl 2-methylnicotinate 1721-26-2
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-12-21