ChemicalBook > CAS DataBase List > 3-Amino-1,2-propanediol

3-Amino-1,2-propanediol

Product Name
3-Amino-1,2-propanediol
CAS No.
616-30-8
Chemical Name
3-Amino-1,2-propanediol
Synonyms
3-AMINOPROPANE-1,2-DIOL;APD;3-AMINO-1,2-PROPANDIOL;Isoserinol;AMINOPROPANEDIOL;3--1,2-;1-AMINOGLYCEROL;1-aminopropanediol;3-Amino-1,2-propaned;Glycerol α-monoamine
CBNumber
CB5701843
Molecular Formula
C3H9NO2
Formula Weight
91.11
MOL File
616-30-8.mol
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3-Amino-1,2-propanediol Property

Melting point:
55-57 °C
Boiling point:
264-265 °C739 mm Hg(lit.)
Density 
1.175 g/mL at 25 °C(lit.)
vapor pressure 
<1 hPa (20 °C)
refractive index 
n20/D 1.492(lit.)
Flash point:
>230 °F
storage temp. 
Store below +30°C.
solubility 
>1000g/l soluble
form 
liquid (highly viscous)
pka
12.11±0.35(Predicted)
color 
Clear colorless to pale yellow
Specific Gravity
1.175
PH
11 (100g/l, H2O, 20℃)
Water Solubility 
soluble
Sensitive 
Hygroscopic
BRN 
1719121
InChIKey
KQIGMPWTAHJUMN-UHFFFAOYSA-N
LogP
-2.079 (est)
CAS DataBase Reference
616-30-8(CAS DataBase Reference)
NIST Chemistry Reference
3-Amino-1,2-propanediol(616-30-8)
EPA Substance Registry System
1,2-Propanediol, 3-amino- (616-30-8)
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Safety

Hazard Codes 
C,Xi
Risk Statements 
34-36/37/38
Safety Statements 
26-36/37/39-45-36
RIDADR 
UN 2735 8/PG 2
WGK Germany 
2
RTECS 
TY2800000
F 
10-21
Hazard Note 
Corrosive
TSCA 
Yes
HazardClass 
8
PackingGroup 
III
HS Code 
29221980
Toxicity
LD50 orally in Rabbit: 7500 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A76001
Product name
(±)-3-Amino-1,2-propanediol
Purity
97%
Packaging
5g
Price
$52.5
Updated
2024/03/01
Sigma-Aldrich
Product number
A76001
Product name
(±)-3-Amino-1,2-propanediol
Purity
97%
Packaging
25g
Price
$129
Updated
2024/03/01
Sigma-Aldrich
Product number
8.18522
Product name
3-Amino-1,2-propanediol
Purity
for synthesis
Packaging
25mL
Price
$92.1
Updated
2024/03/01
TCI Chemical
Product number
A0628
Product name
3-Amino-1,2-propanediol
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$58
Updated
2024/03/01
Alfa Aesar
Product number
B22672
Product name
(±)-3-Amino-1,2-propanediol, 97%
Packaging
25g
Price
$57.65
Updated
2024/03/01
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3-Amino-1,2-propanediol Chemical Properties,Usage,Production

Description

3-Amino-1,2-propanediol (APD) is a calcium metabolism regulator useful in the treatment of Paget's disease, tumor-induced hypercalcemia and other bone disorders involving increased osteoclastic activity.

Chemical Properties

3-Amino-1,2-propanediol is a very viscous transparent colorless to pale yellow liquid with a melting point of 55-57 °C and a boiling point of 264-265 °C. The density at 25 °C is 1.175 g/mL. soluble in water.

Originator

Henkel (W. Germany)

Uses

3-Amino-1,2-propanediol is used in the preparation of iohexol, which is a X-CT non-ionic contrast medium. It acts as a starting material in the production of specialty materials.

Application

3-Amino-1,2-propanediol is used as a reactant in the synthesis of lipid-like delivery molecules(lipidoids) for RNA interference (RNAi) therapeutics. It is also used in the synthesis of the bioactive template to prepare cationic α-helical polypeptides and various cationic polymers for gene delivery. It is also used in the synthesis of Decarbazolyl Carvedilol (D212720), a metabolite of Carvedilol (C184625) found in humans, rats, dogs and mice.

Preparation

3-Amino-1,2-propanediol is synthesized by reacting 3-chloro-1,2-propanediol (CPD) with ammonia in alkaline environment by adding sodium hydroxide. Afterwards, the product undergoes a series of purification steps.

Application

3-Amino-1,2-propanediol is used as a chiral selector ligand, used subsequently for a nucleophilic substitution with the dimethoxytrityl (DMT)-protected.

brand name

Aminomux

General Description

3-Amino-1,2-propanediol is a chiral glycerol derivative. It could used as a hydrogen bond donor in the design of a new deep eutectic solvent which have emerged as a suitable alternative to VOCs (volatile organic compounds) for diverse practical applications including, among others, drug delivery, electrochemistry, material design, extractions and, of course, organic reactions, alone or together twith other sustainable reaction-media[1]. It can also used as a core present in antiviral compounds to skeleton to design a novel class of anti-adenovirus agents[2].

Hazard

3-Amino-1,2-propanediol is Danger.
H314 (93.33%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
H318 (56.36%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

Safety Profile

Poison by intraperitoneal route.Moderately toxic by ingestion. When heated todecomposition it emits toxic fumes of NOx.

storage

3-Amino-1,2-propanediol absorbs moisture and needs to be kept in a container sealed. Store in cool, dry conditions in well-sealed containers.

References

[1] Antenucci A, et al. Design of a New Chiral Deep Eutectic Solvent Based on 3-Amino-1,2-propanediol and Its Application in Organolithium Chemistry. Molecules, 2022; 27.
[2] Mazzotta S, et al. Design, synthesis and in vitro biological evaluation of a novel class of anti-adenovirus agents based on 3-amino-1,2-propanediol. Bioorganic Chemistry, 2021; 114: 105095.

3-Amino-1,2-propanediol Preparation Products And Raw materials

Raw materials

Ammonium hydroxide Potassium hydroxide Methanol 3-Chloro-1,2-propanediol Epichlorohydrin

Preparation Products

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View Lastest Price from 3-Amino-1,2-propanediol manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd
Product
3-Amino-1,2-propanediol 616-30-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T+
Release date
2024-01-18
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
3-Aminopropane-1,2-diol 616-30-8
Price
US $78.00-35.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-05-20
WUHAN FORTUNA CHEMICAL CO., LTD
Product
3-Amino-1,2-propanediol 616-30-8
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
99.7%min
Supply Ability
20000kg
Release date
2021-10-26

616-30-8, 3-Amino-1,2-propanediolRelated Search:

(R)-(-)-1,2-Propanediol 1-Methoxy-2-propyl acetate Propylene glycol 1,3-Propanediol Glycine ALTRENOGEST 3-Aminophenol 1-Phenoxy-2-propanol DI(PROPYLENE GLYCOL) BUTYL ETHER 1-Methoxy-2-propanol 6-Aminocaproic acid 2-METHYL-1,3-PROPANEDIOL 3-Amino-1-propanesulfonic acid 3-Amino-1-hydroxyadamantane Tris(hydroxymethyl)aminomethane 2-AMINOPROPANE-1,3-DIOL,2-AMINO-1,3-PROPANEDIOL [1S,2S,(+)]-1-Phenyl-2-amino-1,3-propanediol 2-AMINO-1,3-PROPANEDIOL HYDROCHLORIDE,2-Amino-1,3-propanediol hydrochloride, 2-Amino-1,3-propanediol

  • 3-Aminopropane-1,2-diol 99%
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  • 3-Amino-1,2-propanediol (Isoserinol)
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  • 3-AMNIO-1,2-PROPANEDIOL
  • 3-AMino-1,2-propanediol, 98% 100GR
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  • (+/-)-3-AMINO-1,2-PROPANEDIOL
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  • 3-AMINOPROPANE-1,2-DIOL
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  • 1-AMINO-2,3-PROPANEDIOL
  • 1-AMINOGLYCEROL
  • 1,2-DIHYDROXY-3-AMINOPROPANE
  • 1,2-DIHYDROXY-1-PROPYLAMINE
  • 1,2-Propanediol, 3-amino-
  • 1-aminopropanediol
  • 2,3-Dihydroxypropylamine
  • 2,3-Propandiol-1-amine
  • 3-amino-2-propanediol
  • APD
  • (+/-)-3-AMINO-1,2-PROPANEEDIOL
  • 3-AMINO-1,2-PROOPANEDIOL
  • 3-Amino-1,2-propanediol USP/EP/BP
  • AMINOPROPANEDIOL
  • (+/-)-3-AMINO-1,2-PROPANEDIOL
  • 3-amino-1,2-propanediol (APD)
  • 1-Aminopropan-2,3-diol
  • 3--1,2-
  • Ethyl Acetate Impurity 32
  • 616-30-8
  • NH2CH2CHOHCH2OH
  • AMINE
  • Oxygen Compounds
  • Organic Building Blocks
  • Amino Alcohols
  • Building Blocks
  • API
  • Alcohols and Derivatives
  • Amino Alcohols
  • Organic Building Blocks
  • Oxygen Compounds
  • 616-30-8