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5-AMINO-2-METHYL-BENZOIC ACID METHYL ESTER

Product Name
5-AMINO-2-METHYL-BENZOIC ACID METHYL ESTER
CAS No.
18595-12-5
Chemical Name
5-AMINO-2-METHYL-BENZOIC ACID METHYL ESTER
Synonyms
Methyl 5-Amino-o-toluate;3-Amino-6-Methyl benzoate;Methyl 2-Methyl-5-aMinobenzoate;5-Amino-o-toluic Acid Methyl Ester;Methyl5-amino-2-methylbenzoate,98%;Methyl 5-Amino-2-methylbenzoate >Methyl 5-amino-2-methylbenzoate 97%;Methyl 5-AMino-2-Methylbenzoate, 95+%;2-Methyl-5-aminobenzoic acid methyl ester;5-AMINO-2-METHYL-BENZOIC ACID METHYL ESTER
CBNumber
CB5804494
Molecular Formula
C9H11NO2
Formula Weight
165.19
MOL File
18595-12-5.mol
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5-AMINO-2-METHYL-BENZOIC ACID METHYL ESTER Property

Melting point:
39-40℃
Boiling point:
285.4±20.0 °C(Predicted)
Density 
1.132±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
soluble in Methanol
form 
Solid
pka
3.88±0.10(Predicted)
color 
Pale brown to red
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Safety

HS Code 
2916310090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical
Product number
M2540
Product name
Methyl 5-Amino-2-methylbenzoate
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$77
Updated
2025/07/31
TCI Chemical
Product number
M2540
Product name
Methyl 5-Amino-2-methylbenzoate
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$307
Updated
2025/07/31
TRC
Product number
M332893
Product name
Methyl 5-Amino-2-methylbenzoate
Packaging
50mg
Price
$45
Updated
2021/12/16
Matrix Scientific
Product number
072751
Product name
Methyl 5-amino-2-methylbenzoate
Purity
95+%
Packaging
25g
Price
$59
Updated
2021/12/16
Matrix Scientific
Product number
072751
Product name
Methyl 5-amino-2-methylbenzoate
Purity
95+%
Packaging
5g
Price
$19
Updated
2021/12/16
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5-AMINO-2-METHYL-BENZOIC ACID METHYL ESTER Chemical Properties,Usage,Production

Synthesis

77324-87-9

18595-12-5

General procedure for the synthesis of methyl 5-amino-2-methylbenzoate (41) from methyl 2-methyl-5-nitrobenzoate: 10% Pd-C (30 mg) was added to a solution of methyl 2-methyl-5-nitrobenzoate (635 mg, 3.3 mmol) in ethyl acetate (10 mL), and the mixture was stirred for 16 h at 23°C in a hydrogen atmosphere. After completion of the reaction, the mixture was filtered through a diatomaceous earth pad and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography to afford the colorless oily product methyl 5-amino-2-methylbenzoate (41) (536 mg, yield >99%), Rf = 0.57 (hexane:ethyl acetate = 1:1).1H NMR (400 MHz, CDCl3): δ 7.11 (d, 1H, J = 2.5 Hz), 6.97 (d, 1H, J = 8.1 Hz), 6.69 (dd, 1H, J = 2.5 and 8.1 Hz), 3.82 (s, 3H), 3.64 (s, 2H), 2.43 (s, 3H).13C NMR (100 MHz, CDCl3): δ 168.1, 144.1, 132.3, 129.8, 129.5, 118.8, 116.7. 51.6, 20.6. MS (EI): m/z 165.20 [M]+. HRMS (EI) calculated value C9H11NO2 [M]+ 165.0790, measured value 165.0787.

References

[1] Journal of the American Chemical Society, 2003, vol. 125, # 40, p. 12074 - 12075
[2] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 10, p. 2823 - 2827
[3] Patent: WO2004/18414, 2004, A2. Location in patent: Page 110
[4] Journal of Medicinal Chemistry, 2009, vol. 52, # 16, p. 5228 - 5240
[5] Patent: US2011/269834, 2011, A1. Location in patent: Page/Page column 29

5-AMINO-2-METHYL-BENZOIC ACID METHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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5-AMINO-2-METHYL-BENZOIC ACID METHYL ESTER Suppliers

Americas 1 China 89 Europe 1 India 8 Japan 1 South Korea 1 Switzerland 2 United Kingdom 4 United States 14 Global 121
TCI AMERICA
Tel
800-4238616
Fax
+1-888-520-1075 / +1-503-283-1987
Email
sales@tciamerica.com
Country
Americas
ProdList
23653
Advantage
75
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View Lastest Price from 5-AMINO-2-METHYL-BENZOIC ACID METHYL ESTER manufacturers

Career Henan Chemical Co
Product
5-AMINO-2-METHYL-BENZOIC ACID METHYL ESTER 18595-12-5
Price
US $1.00/KG
Min. Order
1KG
Purity
95%-99%
Supply Ability
100KG
Release date
2019-08-29

18595-12-5, 5-AMINO-2-METHYL-BENZOIC ACID METHYL ESTERRelated Search:

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