ChemicalBook > CAS DataBase List > 2-Cyano-5-fluoropyridine

2-Cyano-5-fluoropyridine

Product Name
2-Cyano-5-fluoropyridine
CAS No.
327056-62-2
Chemical Name
2-Cyano-5-fluoropyridine
Synonyms
5-Fluoropicolinonitrile;5-Fluoro-2-cyanopyridine;2-Cyano-5-fluorpyridine;2-Cyano-5-fluoropyridine;2-Cyano-5-fluoropyridine, 98+%;5-Fluoropyridin-2-carbonitrile;2-Carbonitrile-5-fluoropyridine;5-Fluoro-2-pyridinecarbonitrile;5-Fluoropyridine-2-carbonitrile;2-Pyridinecarbonitrile, 5-fluoro-
CBNumber
CB5969562
Molecular Formula
C6H3FN2
Formula Weight
122.1
MOL File
327056-62-2.mol
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2-Cyano-5-fluoropyridine Property

Melting point:
35-41 °C
Boiling point:
214.9±20.0 °C(Predicted)
Density 
1.24±0.1 g/cm3(Predicted)
Flash point:
99 °C
storage temp. 
Inert atmosphere,Room Temperature
solubility 
soluble in Methanol
form 
powder to crystal
pka
-2.74±0.10(Predicted)
color 
White to Almost white
InChI
InChI=1S/C6H3FN2/c7-5-1-2-6(3-8)9-4-5/h1-2,4H
InChIKey
BHXHRMVSUUPOLX-UHFFFAOYSA-N
SMILES
C1(C#N)=NC=C(F)C=C1
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Safety

Hazard Codes 
Xn,N
Risk Statements 
22-41-50/53
Safety Statements 
26-39-60-61
RIDADR 
UN3439
WGK Germany 
3
HazardClass 
6.1
PackingGroup 
III
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
703982
Product name
2-Cyano-5-fluoropyridine
Purity
97%
Packaging
5g
Price
$69.5
Updated
2025/07/31
Sigma-Aldrich
Product number
703982
Product name
2-Cyano-5-fluoropyridine
Purity
97%
Packaging
1g
Price
$33.4
Updated
2023/06/20
TCI Chemical
Product number
C3286
Product name
2-Cyano-5-fluoropyridine
Purity
>98.0%(GC)
Packaging
1g
Price
$25
Updated
2025/07/31
TCI Chemical
Product number
C3286
Product name
2-Cyano-5-fluoropyridine
Purity
>98.0%(GC)
Packaging
5g
Price
$76
Updated
2025/07/31
TRC
Product number
F596305
Product name
5-Fluoropyridine-2-carbonitrile
Packaging
1g
Price
$75
Updated
2021/12/16
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2-Cyano-5-fluoropyridine Chemical Properties,Usage,Production

Uses

5-Fluoro-2-pyridinecarbonitrile is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Definition

ChEBI: 2-Cyano-5-fluoropyridine is a member of pyridines.

Synthesis

55338-73-3

327056-62-2

General procedure for the synthesis of 2-cyano-5-fluoropyridine from 3-amino-6-cyanopyridine: Sodium nitrite (8.7 g, 126 mmol) was added in batches to ice-salt-bath-cooled 5-amino-pyridine-2-carbonitrile (10.03 g, 84.2 mmol) dissolved in a solution of 70% hydrogen fluoride-pyridine (Aldrich, 100 g, 3.5 mol HF) ( Note: the reaction was carried out in a special reaction flask). The reaction solution was dark red in color, and after stirring in an ice-salt bath for 45 min, the ice bath was removed and the mixture continued to be stirred at room temperature for 30 min, followed by heating at 80 °C for 1.5 h. The reaction was carried out in a special reaction flask. Upon completion of the reaction, the reaction mixture was quenched by slowly pouring it into an ice/water mixture (about 400 g), extracted with dichloromethane (6 x 150 mL), the organic phase was dried over anhydrous magnesium sulfate, filtered and the solvent was concentrated under reduced pressure. The resulting crude product (10.08 g, 98% yield, orange solid) was pure enough for subsequent use and did not require further purification. The product was characterized by 1H NMR (CDCl3, 300 MHz): δ= 8.61 (d, 1H), 7.78 (m, 1H), 7.58 (m, 1H).GC-MS showed the molecular ion peak M+ 122.

References

[1] Patent: WO2005/66155, 2005, A1. Location in patent: Page/Page column 23
[2] Patent: EP1621537, 2006, A1. Location in patent: Page/Page column 57-58
[3] Patent: EP1640366, 2006, A1. Location in patent: Page/Page column 137-138
[4] Patent: EP1803719, 2007, A1. Location in patent: Page/Page column 27
[5] Patent: US2010/41717, 2010, A1. Location in patent: Page/Page column 41-42

2-Cyano-5-fluoropyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Cyano-5-fluoropyridine Suppliers

Americas 1 Belgium 1 China 226 Europe 2 France 1 Germany 5 India 8 Italy 1 Japan 2 Jordan 1 Switzerland 1 The Netherlands 1 United Kingdom 9 United States 41 Global 300
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View Lastest Price from 2-Cyano-5-fluoropyridine manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
2-Cyano-5-fluoropyridine 327056-62-2
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-13
Zhuozhou Wenxi import and Export Co., Ltd
Product
2-Cyano-5-fluoropyridine 327056-62-2
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-11
Zhuozhou Wenxi import and Export Co., Ltd
Product
2-Cyano-5-fluoropyridine 327056-62-2
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09

327056-62-2, 2-Cyano-5-fluoropyridineRelated Search:

2-Pyrimidinecarbonitrile, 5-chloro- (9CI) 4-CHLORO-PYRIDINE-2-CARBONITRILE 5-Bromo-6-methyl-2-pyridinecarbonitrile 2-Cyano-5-methylpyridine 4-Bromomethyl-2-cyanobiphenyl 5-Bromo-2-pyridinecarbonitrile 2-BROMO-5-NITRO-6-PICOLINE 3-Amino-5-fluoropyridine 2-METHOXY-5-NITRO-6-PICOLINE 2-Pyridinecarboxylic acid, 3-fluoro-4-iodo- 3-FLUOROPYRIDINE-2-CARBOXYLIC ACID 4-Methoxy-3-nitropyridine 2-HYDROXY-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE 2-Cyano-4-fluoropyridine 3-Bromo-2-cyanopyridine 6-Methylpyridine-2-carbonitrile (5-TRIFLUOROMETHYL-PYRIDIN-2-YL)-ACETONITRILE 2-Cyano-5-nitropyridine

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