ChemicalBook > CAS DataBase List > 3-Bromo-4-hydroxypyridine

3-Bromo-4-hydroxypyridine

Product Name
3-Bromo-4-hydroxypyridine
CAS No.
36953-41-0
Chemical Name
3-Bromo-4-hydroxypyridine
Synonyms
3-Bromopyridin-4-ol;3-BROMO-4-PYRIDINOL;4-Pyridinol, 3-bromo-;3-bromo-1H-pyridin-4-one;4-HYDROXY-3-BROMOPYRIDINE;3-BROMO-4-HYDROXYPYRIDINE;3-BROMO-4-HYDROXYPYRIDINE 97%;3-Bromo-4-hydroxypyridine,97%;Synthesis of 3-bromopyridin-4-ol;3-Bromo-4-hydroxypyridine ISO 9001：2015 REACH
CBNumber
CB6110145
Molecular Formula
C5H4BrNO
Formula Weight
174
MOL File
36953-41-0.mol
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3-Bromo-4-hydroxypyridine Property

Melting point:
225-230℃
Boiling point:
338.2±22.0 °C(Predicted)
Density 
1.788±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
form 
powder
pka
3.71±0.18(Predicted)
color 
light yellow
CAS DataBase Reference
36953-41-0(CAS DataBase Reference)
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC
Product number
B698850
Product name
3-Bromopyridin-4-ol
Packaging
250mg
Price
$55
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB140263
Product name
3-Bromopyridin-4-ol
Packaging
2g
Price
$74
Updated
2021/12/16
Matrix Scientific
Product number
071865
Product name
3-Bromo-4-pyridinol
Purity
95+%
Packaging
1g
Price
$35
Updated
2021/12/16
SynQuest Laboratories
Product number
4H56-9-X4
Product name
3-Bromo-4-hydroxypyridine
Packaging
1g
Price
$84
Updated
2021/12/16
AK Scientific
Product number
W5810
Product name
3-Bromo-4-pyridinol
Packaging
5g
Price
$94
Updated
2021/12/16
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3-Bromo-4-hydroxypyridine Chemical Properties,Usage,Production

Uses

3-Bromo-4-hydroxypyridine is a pyrrole that can be used in cancer treatment. It inhibits the growth of cancer cells by binding to MKN-45 on the cell surface, thereby preventing it from binding to other proteins and triggering cell proliferation.

Synthesis

3-Bromo-4-hydroxypyridine is synthesized from 3-bromo-5 hydroxypyridine by reacting it with ammonia or methylamine.
Concentrated sulfuric acid (85.0mL) and the 3-bromo-4-aminopyridine (113.0g, 0.65mol) were added successively to the distilled water (550.0mL) at 0°C, and then NaNO2 (63.1g, 0.91mol) aqueous solution (130.0mL) was added drop-wise to maintain the temperature between 0 and 5°C. After stirring at r. t. for 1h, the reaction mixture was heated at 95°C for a further 0.5h. Upon cooling to below 0°C, the mixture was alkalized to pH 6 with saturated sodium hydroxide solution, washed with ethyl acetate (200mL×3) and brine (200mL), dried over anhydrous Na2SO4, filtered and concentrated to yield 3-Bromo-4-hydroxypyridine as a yellow solid (75.1g, 66.2percent).

References

[1] Patent: US2010/93720, 2010, A1. Location in patent: Page/Page column 58
[2] Synlett, 2003, # 11, p. 1678 - 1682
[3] Patent: WO2012/148808, 2012, A1. Location in patent: Page/Page column 51

3-Bromo-4-hydroxypyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-Bromo-4-hydroxypyridine manufacturers

Dideu Industries Group Limited
Product
3-Bromo-4-hydroxypyridine 36953-41-0
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-09-24
Zhuozhou Wenxi import and Export Co., Ltd
Product
3-Bromo-4-hydroxypyridine 36953-41-0
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-11
Career Henan Chemical Co
Product
3-Bromo-4-hydroxypyridine 36953-41-0
Price
US $3.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2019-07-04

36953-41-0, 3-Bromo-4-hydroxypyridineRelated Search:

1-Hexadecylpyridinium bromide 3-Aminopyridine 3-Hydroxypyridine 4-Hydroxypyridine 3-Bromoanisole 3-BROMO-4-FLUOROPYRIDINE 2-Chloro-3-cyanopyridine 3-BROMO-4-METHOXY-PYRIDINE Bromine 3-BROMO-5-HYDROXYPYRIDINE,5-BROMO-3-HYDROXYPYRIDINE 4-BROMO-2-HYDROXYPYRIDINE 3-BROMO-2-HYDROXYPYRIDINE METHYL 5-BROMO-2-HYDROXYPYRIDINE-3-CARBOXYLATE 3,5-DIBROMO-2-HYDROXYPYRIDINE 4-BROMO-3-HYDROXYPYRIDINE Methyl 5-Bromo-2-hydroxypyridine-4-carboxylate, 5-Bromo-4-methoxycarbonyl-2(1H)-pyridinone 5-BROMO-6-HYDROXYPYRIDINE-3-CARBOXYLIC ACID 2-Bromo-4-Hydroxypyridine

  • 3-BROMO-4-HYDROXYPYRIDINE
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  • 3-Bromopyridin-4-ol
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  • 3-Bromo-4-hydroxypyridine,97%
  • 3-Bromo-4-hydroxypyridine ISO 9001：2015 REACH
  • 3-bromo-1H-pyridin-4-one
  • 36953-41-0
  • 133466-43-8
  • Pyridine
  • Pyridines