ChemicalBook > CAS DataBase List > 4,5,6,7-Tetrahydrothieno[3,2,c] pyridine hydrochloride

4,5,6,7-Tetrahydrothieno[3,2,c] pyridine hydrochloride

Product Name
4,5,6,7-Tetrahydrothieno[3,2,c] pyridine hydrochloride
CAS No.
28783-41-7
Chemical Name
4,5,6,7-Tetrahydrothieno[3,2,c] pyridine hydrochloride
Synonyms
4,5,6,7-TETRAHYDROTHIENO[3,2-C]PYRIDINE HYDROCHLORIDE;Clopidogrel-7;2-c]pyridine HCl;7-Tetrahydrothieno[3;Pragrace Impurity 23;Zidovudine impurity F;Clopidogrel Impurity 56;Clopidogrel Impurities6;Clopidogrel Impurities195;Prasugrel Impurity 23 HCl
CBNumber
CB6122076
Molecular Formula
C7H9NS
Formula Weight
139.22
MOL File
28783-41-7.mol
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4,5,6,7-Tetrahydrothieno[3,2,c] pyridine hydrochloride Property

Melting point:
212-215°C
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
DMSO, Methanol, Water
form 
Solid
color 
White to Off-White
InChI
InChI=1S/C7H9NS/c1-3-8-5-6-2-4-9-7(1)6/h2,4,8H,1,3,5H2
InChIKey
OGUWOLDNYOTRBO-UHFFFAOYSA-N
SMILES
C12CNCCC=1SC=C2
CAS DataBase Reference
28783-41-7(CAS DataBase Reference)
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Safety

Risk Statements 
36/37/38
Safety Statements 
26-36/37/39-37
RIDADR 
UN2811
HazardClass 
IRRITANT
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical
Product number
T2770
Product name
4,5,6,7-Tetrahydrothieno[3,2-c]pyridine Hydrochloride
Purity
>98.0%(HPLC)(N)
Packaging
5g
Price
$18
Updated
2025/07/31
TCI Chemical
Product number
T2770
Product name
4,5,6,7-Tetrahydrothieno[3,2-c]pyridine Hydrochloride
Purity
>98.0%(HPLC)(N)
Packaging
25g
Price
$50
Updated
2025/07/31
TRC
Product number
T295750
Product name
4,5,6,7-Tetrahydrothieno[3,2-c]pyridine Hydrochloride
Packaging
5g
Price
$120
Updated
2021/12/16
Usbiological
Product number
T2972-12
Product name
4,5,6,7-Tetrahydro-thieno[3,2-c]pyridine Hydrochloride
Packaging
1g
Price
$403
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
13746
Product name
4,5,6,7-Tetrahydrothieno[3,2-c]pyridine Hydrochloride
Packaging
5G
Price
$590
Updated
2021/12/16
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4,5,6,7-Tetrahydrothieno[3,2,c] pyridine hydrochloride Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

An intemediate of Clopidogrel and Prasugrel.

Synthesis

30433-91-1

50-00-0

28783-41-7

Example 5: Preparation of 4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrochloride In a 2-liter four-necked flask equipped with a thermometer and a mechanical stirrer, 2-thiophene ethylamine (100 g, 0.79 mol) was added. The reaction was dissolved in dichloromethane (600 ml) at 25°C (±5°C) and stirred for 5 to 10 minutes. Subsequently, paraformaldehyde (26.4 g, 0.88 mole) was added to the reaction system and the reaction was subjected to azeotropic reflux at 40 to 45°C for 4 to 6 hours. Upon completion of the reaction, the system was cooled to room temperature and a N,N-dimethylformamide solution (200 ml) of 7% hydrochloric acid was slowly added at 25 °C (±5 °C). The reaction mixture was continued to be stirred at 70°C (±5°C) for 4 to 6 hours. Afterwards, the reaction solution was cooled to 15 °C (±2 °C) and stirred for 8 to 10 hours to promote crystallization. The solid product was collected by filtration and washed with pre-cooled dichloromethane. Finally, the product was dried under vacuum at 30 to 40 °C to afford 4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrochloride (120 g, 99% yield).

References

[1] Patent: WO2012/1486, 2012, A1. Location in patent: Page/Page column 18
[2] Journal of Organic Chemistry, 2015, vol. 80, # 14, p. 7019 - 7032
[3] Patent: EP1772455, 2007, A2. Location in patent: Page/Page column 9
[4] Journal of Organometallic Chemistry, 2009, vol. 694, # 13, p. 2092 - 2095
[5] Patent: US2004/24011, 2004, A1. Location in patent: Page 7

4,5,6,7-Tetrahydrothieno[3,2,c] pyridine hydrochloride Preparation Products And Raw materials

Raw materials

2-Thiophenecarboxaldehyde Nitromethane Thiophene-2-ethylamine Formaldehyde 1,3-Dioxolane Tetrahydrofuran Ammonium chloride Ethyl acetate Lithium Aluminum Hydride Hydrochloric acid Methanol Isopropyl alcohol Sulfuric acid

Preparation Products

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4,5,6,7-Tetrahydrothieno[3,2,c] pyridine hydrochloride Suppliers

Canada 1 China 314 Europe 2 Germany 5 India 24 Japan 1 Slovakia 1 South Korea 1 Ukraine 2 United Kingdom 9 United States 36 Global 396
ecochem international chemical broker
Tel
--
Fax
--
Email
export@ecochem.dk
Country
Europe
ProdList
6371
Advantage
66
kemikalieimport
Tel
--
Fax
--
Email
Sales@kemikalieimport.dk
Country
Europe
ProdList
6685
Advantage
47
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View Lastest Price from 4,5,6,7-Tetrahydrothieno[3,2,c] pyridine hydrochloride manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
4,5,6,7-Tetrahydrothieno[3,2,c] pyridine hydrochloride 28783-41-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-27
Henan Fengda Chemical Co., Ltd
Product
4,5,6,7-Tetrahydrothieno[3,2-c]pyridine (hydrochloride) 28783-41-7
Price
US $6.00-0.90/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-01-24
Hebei Zhanyao Biotechnology Co. Ltd
Product
4,5,6,7-Tetrahydrothieno[3,2,c] pyridine hydrochloride 28783-41-7
Price
US $10.00/Kg/Bag
Min. Order
1Kg/Bag
Purity
99%
Supply Ability
20 Tons
Release date
2021-11-04

28783-41-7, 4,5,6,7-Tetrahydrothieno[3,2,c] pyridine hydrochlorideRelated Search:

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  • Zidovudine impurity F
  • 2-c]pyridine HCl
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  • Clopidogrel Impurity 24 HCl
  • Clopidogrel-7
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  • Clopidogrel Thieno Impurity HCl
  • Pragrace Impurity 23
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  • 4,5,6,7-Tetrahydrothieno[3,2-c]pyridine hydrochloride (Clopidogrel Impurity)
  • Clopidogrel Impurities195
  • Clopidogrel Impurities6
  • 4,5,6,7-Tetrahydrothieno[3,2,-c] pyridine hydrochlorideQ: What is 4,5,6,7-Tetrahydrothieno[3,2,-c] pyridine hydrochloride Q: What is the CAS Number of 4,5,6,7-Tetrahydrothieno[3,2,-c] pyridine hydrochloride Q: What is the storage condition of 4,5,6,7-Tetrahydrothieno[3,2,-c] pyridine hydrochloride Q: What are the applications of 4,5,6,7-Tetrahydrothieno[3,2,-c] pyridine hydrochloride
  • Al 4,5,6,7 -Teirahydro [3,2-C] Thieno Pyridine Hydrochloride
  • Tetrahydrothieno pyridine (THTP)
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  • Clopidogrel EP Impurity 22
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  • 28783-41-7
  • C7H9NSClH
  • C7H9NSHClC7H10ClNS
  • C7H9SNHCl
  • C7H9NSHCl
  • C7H10ClNS
  • Prasugrel Intermediates
  • Heterocycle-Pyridine series
  • Heterocyclic Compounds
  • Bases & Related Reagents
  • Heterocycles
  • Nucleotides
  • Sulfur & Selenium Compounds
  • Intermediates