ChemicalBook > CAS DataBase List > Olesoxime

Olesoxime

Product Name
Olesoxime
CAS No.
22033-87-0
Chemical Name
Olesoxime
Synonyms
TRO19266;NSC 21311;olesoxime;TRO 19622;Olesoxime (TRO-19622);Cholest-4-en-3-one oxime;OLESOXIME;NSC 21311;TRO19622;TRO-19622;Cholest-4-en-3-one, oxime, NSC 21311;Inhibitor,NSC21311,NSC-21311,TRO19622,Olesoxime,inhibit,TRO-19622,Mitochondrial Metabolism;(NE)-N-[10,13-dimethyl-17-(6-methylheptan-2-yl)-1,2,6,7,8,9,11,12,14,1 5,16,17-dodecahydrocyclopenta[a]phenanthren-3-ylidene]hydroxylamine
CBNumber
CB61254361
Molecular Formula
C27H45NO
Formula Weight
399.65
MOL File
22033-87-0.mol
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Olesoxime Property

Melting point:
145-148 ºC
Boiling point:
510.0±23.0 °C(Predicted)
Density 
1.10
storage temp. 
-20°C
solubility 
DMSO: >10mg/mL
form 
solid
pka
12.27±0.70(Predicted)
color 
white
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
CAS DataBase Reference
22033-87-0(CAS DataBase Reference)
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T3077
Product name
TRO 19622
Purity
≥98% (HPLC), solid
Packaging
5mg
Price
$149
Updated
2024/03/01
Sigma-Aldrich
Product number
T3077
Product name
TRO 19622
Purity
≥98% (HPLC), solid
Packaging
25mg
Price
$528
Updated
2024/03/01
Cayman Chemical
Product number
21264
Product name
TRO 19622
Purity
≥95% (mixture of isomers)
Packaging
10mg
Price
$121
Updated
2024/03/01
Cayman Chemical
Product number
21264
Product name
TRO 19622
Purity
≥95% (mixture of isomers)
Packaging
50mg
Price
$543
Updated
2024/03/01
Cayman Chemical
Product number
21264
Product name
TRO 19622
Purity
≥95% (mixture of isomers)
Packaging
100mg
Price
$961
Updated
2024/03/01
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Olesoxime Chemical Properties,Usage,Production

Description

TRO19622 (22033-87-0) is a neuroregenerative and neuroprotective agent acting at components of the mitochondrial permeability transition pore (MPTP).1?Rescues motor neurons from axotomy-induced cell death and promotes nerve regeneration following sciatic nerve crush in mice. Reduces ROS and NLRP3 inflammasome activation in a mouse model of intracerebral hemorrhage.2?Inhibits MPTP opening and protects neurons from apoptosis.3?Induces oligodendrocyte maturation in culture and promotes myelin regeneration?in vivo?in a rodent model.4

Uses

TRO 19622 interacts with mitochondria proteins and is able to promote neuron survival under stress conditions. It is a potential drug for treating amyotrophic lateral sclerosis (ALS). TRO 19622 is a neuroregenerative and neuroprotective agent. This is a research product for neuroscience.

Uses

TRO 19622 has been used as a mitochondrial permeability transition pore inhibitor in mouse neurons2. TRO 19622 is also known to stimulate myelin repair in rat models of demyelination3.

Biological Activity

Neuroprotective and neuroregenerative compound. Rescues motor neurons from axotomy-induced cell death and promotes nerve regeneration following sciatic nerve crush in vivo . Binds directly to two components of the mitochondrial permeability pore, the voltage-dependent anion channel (VDAC) and translocator protein.

Biochem/physiol Actions

TRO 19622 can decrease axonal degradation and enhance the rescue of motor nerve conduction in peripheral neuropathy. Furthermore, TRO 19622 can reverse neuropathic pain and tactile allodynia in rat models of diabetes and chemotherapy-induced neuropathic pain4.

storage

Desiccate at +4°C

References

1) Bordet?et al.?(2007),?Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis; J. Pharmacol. Exp. Ther.,?322?709 2) Ma?et al.?(2014),?NLRP3 inflammasome contributes to inflammation after intracerebral hemorrhage; Ann. Neurol.,?75?209 3) Martin?et al.?(2011),?The mitochondrial permeability transition pore regulates nitric oxide-mediated apoptosis of neurons induced by target deprivation; J. Neurosci.,?31?359 4) Magalon?et al. (2016),?Olesoxime favors oligodendrocyte differentiation through a functional interplay between mitochondria and microtubules; Neuropharmacology,?111?293

Olesoxime Preparation Products And Raw materials

Raw materials

Preparation Products

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Olesoxime Suppliers

China 53 Germany 1 India 1 Switzerland 1 United Kingdom 1 United States 19 Global 76
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22033-87-0, OlesoximeRelated Search:

Simvastatin (1R,4aS,10aR)-1,2,3,4,4a,9,10,10a-Octahydro-1-,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenemethanamine hydrochloride Lovastatin antibiotic 1233A Orlistat Dimethylglyoxime Androstenedione 4-Cholesten-3-one Clethodim 6-Methyl-5-hepten-2-one Zearalenone Trenbolone Quinocetone OXIME Olesoxime CHOLEST-4-ENE

  • (NE)-N-[10,13-dimethyl-17-(6-methylheptan-2-yl)-1,2,6,7,8,9,11,12,14,1 5,16,17-dodecahydrocyclopenta[a]phenanthren-3-ylidene]hydroxylamine
  • olesoxime
  • Cholest-4-en-3-one, oxime, NSC 21311
  • TRO 19622
  • Cholest-4-en-3-one oxime
  • NSC 21311
  • TRO19266
  • OLESOXIME;NSC 21311;TRO19622;TRO-19622
  • (8s,9s,10r,13r,14s,17r)-10,13-dimethyl-17-((r)-6-methylheptan-2-yl)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one oxime
  • Olesoxime (TRO-19622)
  • Inhibitor,NSC21311,NSC-21311,TRO19622,Olesoxime,inhibit,TRO-19622,Mitochondrial Metabolism
  • (8S,9S,10R,13R,14S,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one oxime
  • 22033-87-0