2-CHLORO-1,3-THIAZOLE-4-CARBOXYLIC ACID
- Product Name
- 2-CHLORO-1,3-THIAZOLE-4-CARBOXYLIC ACID
- CAS No.
- 5198-87-8
- Chemical Name
- 2-CHLORO-1,3-THIAZOLE-4-CARBOXYLIC ACID
- Synonyms
- 4-Carboxy-2-chloro-1,3-thiazole;2-Chloro-4-thiazolecarboxylic acid;4-Thiazolecarboxylic acid, 2-chloro-;2-CHLORO-1,3-THIAZOLE-4-CARBOXYLIC ACID;2-Chlorothiazole-4-Carboxylic Acid(WXC02298)
- CBNumber
- CB61516890
- Molecular Formula
- C4H2ClNO2S
- Formula Weight
- 163.58
- MOL File
- 5198-87-8.mol
2-CHLORO-1,3-THIAZOLE-4-CARBOXYLIC ACID Property
- Melting point:
- 220 °C
- Boiling point:
- 370.2±34.0 °C(Predicted)
- Density
- 1.693±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- Crystalline Powder
- pka
- 3.15±0.10(Predicted)
- color
- White to yellow
- InChI
- InChI=1S/C4H2ClNO2S/c5-4-6-2(1-9-4)3(7)8/h1H,(H,7,8)
- InChIKey
- UVYJJJQMZPCYKY-UHFFFAOYSA-N
- SMILES
- S1C=C(C(O)=O)N=C1Cl
Safety
- Hazard Codes
- Xi
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 2934100090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- JRD0389
- Product name
- Ethyl 2-chlorothiazole-4-carboxylate
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $73.1
- Updated
- 2025/07/31
- Product number
- JRD0388
- Product name
- 2-Chlorothiazole-4-carboxylic acid
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $107
- Updated
- 2025/07/31
- Product number
- C3349
- Product name
- 2-Chlorothiazole-4-carboxylic Acid
- Packaging
- 1G
- Price
- $105
- Updated
- 2025/07/31
- Product number
- C411463
- Product name
- 2-Chloro-1,3-thiazole-4-carboxylicacid
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- 8H21-5-X3
- Product name
- 2-Chloro-1,3-thiazole-4-carboxylic acid
- Packaging
- 1g
- Price
- $56
- Updated
- 2021/12/16
2-CHLORO-1,3-THIAZOLE-4-CARBOXYLIC ACID Chemical Properties,Usage,Production
Synthesis
41731-52-6
5198-87-8
The general procedure for the synthesis of 2-chloro-1,3-thiazole-4-carboxylic acid from ethyl 2-chlorothiazole-4-carboxylate was as follows: 14.0 g (73.1 mmol) of ethyl 2-chlorothiazole-4-carboxylate was slowly added to 11.0 g (0.17 mol, 85% purity) of potassium hydroxide in a solution of ethanol/water (1:3, 200 mL), keeping the reaction temperature at 0 °C. The reaction mixture was stirred at room temperature for 16 hours before being diluted with water and washed twice with ether. Subsequently, the aqueous layer was acidified to pH=5.5 with concentrated hydrochloric acid and stirring was continued at room temperature for three days. The precipitate formed was collected by filtration and dried under vacuum at 40°C to give 7.0 g (56% yield, 95% purity) of 2-chloro-1,3-thiazole-4-carboxylic acid as a brown solid product.
References
[1] Patent: WO2011/3796, 2011, A1. Location in patent: Page/Page column 126; 127
[2] Helvetica Chimica Acta, 1944, vol. 27, p. 1432,1433
[3] Patent: US5498630, 1996, A
[4] Patent: WO2007/146066, 2007, A2. Location in patent: Page/Page column 152
2-CHLORO-1,3-THIAZOLE-4-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
2-CHLORO-1,3-THIAZOLE-4-CARBOXYLIC ACID Suppliers
- Tel
- 320-37350700
- Fax
- +32 (0)37350701
- sales@tcieurope.eu
- Country
- Europe
- ProdList
- 23671
- Advantage
- 75
View Lastest Price from 2-CHLORO-1,3-THIAZOLE-4-CARBOXYLIC ACID manufacturers
- Product
- 2-CHLORO-1,3-THIAZOLE-4-CARBOXYLIC ACID 5198-87-8
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 1000KGS
- Release date
- 2020-01-10