2,4-Dichloropyrimidine

ChemicalBook > CAS DataBase List > 2,4-Dichloropyrimidine

2,4-Dichloropyrimidine

Product Name: 2,4-Dichloropyrimidine
CAS No.: 3934-20-1
Chemical Name: 2,4-Dichloropyrimidine
Synonyms: 2,4-dichloropyrimidine hydrochloride;2,4DCPY;NSC 20212;NSC 37531;NSC 49119;AKOS 91058;2,4-Dichlorpyrimidin;2,4-Dichloropyrimidi;4-DichloropyriMidine;Pazopanib Impurity 45
CBNumber: CB6202781
Molecular Formula: C4H2Cl2N2
Formula Weight: 148.98
MOL File: 3934-20-1.mol

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2,4-Dichloropyrimidine Property

Melting point:: 57-61 °C (lit.)
Boiling point:: 101 °C/23 mmHg (lit.)
Density: 1.6445 (rough estimate)
refractive index: 1.6300 (estimate)
Flash point:: 101°C/23mm
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form: Powder, Crystals and/or Chunks
pka: -2.84±0.20(Predicted)
color: White to yellow to beige or grayish
Water Solubility: Soluble in water (partly), methanol, chloroform, and ethyl acetate.
Sensitive: Moisture Sensitive
BRN: 110911
InChIKey: BTTNYQZNBZNDOR-UHFFFAOYSA-N
CAS DataBase Reference: 3934-20-1(CAS DataBase Reference)
NIST Chemistry Reference: Pyrimidine, 2,4-dichloro-(3934-20-1)
EPA Substance Registry System: Pyrimidine, 2,4-dichloro- (3934-20-1)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-28A
RIDADR: 1759
WGK Germany: 3
TSCA: Yes
HazardClass: 8
PackingGroup: III
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 143847
Product name: 2,4-Dichloropyrimidine
Purity: 98%
Packaging: 10g
Price: $84.2
Updated: 2024/03/01

Sigma-Aldrich

Product number: 143847
Product name: 2,4-Dichloropyrimidine
Purity: 98%
Packaging: 50g
Price: $306
Updated: 2024/03/01

TCI Chemical

Product number: D2310
Product name: 2,4-Dichloropyrimidine
Purity: >98.0%(GC)
Packaging: 5g
Price: $39
Updated: 2024/03/01

TCI Chemical

Product number: D2310
Product name: 2,4-Dichloropyrimidine
Purity: >98.0%(GC)
Packaging: 25g
Price: $113
Updated: 2024/03/01

Alfa Aesar

Product number: A15131
Product name: 2,4-Dichloropyrimidine, 98+%
Packaging: 5g
Price: $50.65
Updated: 2024/03/01

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2,4-Dichloropyrimidine Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

2,4-Dichloropyrimidine was used in the synthesis of medicinally important 4-aryl-5-pyrimidinylimidazoles.

Preparation

Obtained by chlorination of uracil. Add uracil, phosphorus trichloride, and xylene amine into the reaction pot, heat to 130 ℃, reflux for about 45min, slightly cool, put in crushed ice, that is, the precipitation of purple solid, filtered while hot and not dissolved, washed with ice water, vacuum drying, a kind of purple crude, decolorized with petroleum ether (boiling range of 60-90 ℃), recrystallized, obtained 2,4-dichloropyrimidine.

General Description

2,4-Dichloropyrimidine is a human skin sensitizer. It undergoes effective one-pot, regioselective double Suzuki coupling reaction to yield diarylated pyrimidines.

Reactivity Profile

The reaction of N-substituted cyclic amines with 2,4-dichloroquinazoline and 2,4-dichloro-5-methyl-pyrimidine afforded 2-amino-4-chloroquinazolines and 2-amino-4-chloro-5-methylpyrimidines, respectively—the reaction of these amines with 2,4-dichloropyrimidine 3a afforded not only 2-amino-4-chloropyrimidines but also the isomeric 4-amino-2-chloropyrimidines. An effective one-pot, regioselective double Suzuki coupling of 2,4-dichloropyrimidine has been developed. This method enables the quick and efficient synthesis of diarylated pyrimidines. The choice of solvent proved critical to the success of this reaction sequence, with alcoholic solvent mixtures affording much greater reactivity and correspondingly lower temperatures than polar aprotic solvents[5-6].

References

[1] DR. AGNES FIZIA. Cyclopalladation in the Periphery of a NHC Ligand as the Crucial Step in the Synthesis of Highly Active Suzuki–Miyaura Cross-Coupling Catalysts[J]. Chemistry - A European Journal, 2017. DOI:10.1002/chem.201702877.
[2] FABIAN BRUENING Lucie E L. Highly Regioselective Organocatalytic SNAr Amination of 2,4-Dichloropyrimidine and Related Heteroaryl Chlorides[J]. European Journal of Organic Chemistry, 2017. DOI:10.1002/ejoc.201700459.
[3] ANDERSONSAMANTHA C HandyScott T. One-pot Double Suzuki Couplings of Dichloropyrimidines.[J]. Synthesis-Stuttgart, 2010. DOI:10.1055/s-0030-1258150.
[4] TOMá? KUBELKA. Synthesis of 2,4-Disubstituted Pyrimidin-5-yl C-2′-Deoxyribonucleosides by Sequential Regioselective Reactions of 2,4-Dichloropyrimidine Nucleosides[J]. European Journal of Organic Chemistry, 2010. DOI:10.1002/ejoc.201000164.
[5] Kenji Yoshida, M. Taguchi. “Reaction of N-substituted cyclic amines with 2,4-dichloroquinazoline, 2,4-dichloropyrimidine, and its 5-methyl derivative.” Journal of The Chemical Society-perkin Transactions 1 102 1 (1992): 919–922.
[6] Samantha C Anderson, Scott T Handy. “One-pot Double Suzuki Couplings of Dichloropyrimidines.” Synthesis-Stuttgart 2010 16 (2010): 2721–2724.

2,4-Dichloropyrimidine Preparation Products And Raw materials

Raw materials

Phosphorus oxychloride Uracil Xylidine

Preparation Products

5-FORMYL-2,4-DIMETHOXYPYRIMIDINE (E)-5-(2-CARBOXYVINYL)-2,4-DIMETHOXYPYRIMIDINE 2,4-DIETHOXYPYRIMIDINE 2,4-Dimethoxypyrimidine 4-Hydroxypyrimidine Chlorimuron-ethyl 4-BENZYLOXY-2-CHLOROPYRIMIDINE 5-Iodo-2,4-dimethoxypyrimidine 4-Amino-2-chloropyrimidine 2-CHLORO-4-(N,N-DIMETHYLAMINO)PYRIMIDINE 2-Chloro-4-hydrazinopyrimidine 2-CHLORO(BROMO)PYRIMIDINE N4-Methylcytosine

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View Lastest Price from 2,4-Dichloropyrimidine manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: 2,4-Dichloropyrimidine 3934-20-1
Price: US $55.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000kg/week
Release date: 2024-06-03

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 2,4-Dichloropyrimidine 3934-20-1
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99
Supply Ability: 5000
Release date: 2024-11-12

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 2,4-Dichloropyrimidine 3934-20-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 1000kg
Release date: 2023-01-13

3934-20-1, 2,4-DichloropyrimidineRelated Search:

4,6-Dichloropyrimidine ,98%,4 6-DICHLOROPYRIMIDINE 99% 2-Amino-4,6-dimethylpyrimidine 2-Amino-4,6-dimethoxypyrimidine 3-Methyl-6-nitroindazole 2-Ethyl-5-nitrobenzenamine ,98% 5-Amino-2-methylbenzenesulfonamide N4-(2,3-Dimethyl-2H-indazol-6-yl)-N4-methyl-2,4-pyrimidinediamine 3-methyl-1H-indazol-6-amine 5-Amino-2,3-dimethyl-2H-indazole Pazopanib Impurity 32 Benzenamine, 2-ethyl-4-nitro- 3-AMINO-4-METHYLBENZENESULFONAMIDE 2-amino-5-methylbenzenesulfonamide Pazopanib-d6 2H-Indazol-4-amine, 2,3-dimethyl- 1H-Indazol-6-amine, N-(2-chloro-4-pyrimidinyl)-3-methyl- 6-Nitroindazole Pazopanib Impurity 48

2,4-DICHLOROPYRIMIDINE

2,6-DICHLOROPYRIMIDINE

2-4-DICHLOROPYRIMIDINE CRYSTALLINE

AKOS 91058

2,4-dichloro-pyrimidin

2,4-Dichlorpyrimidin

Pyrimidine,2,4-dichloro-

2,4-Dichloropyrimidine Pazopanib

2,4DCPY

2,4-Dichloropyrimidine, 98+%

Pyrimidine, 2,4-dichloro- (7CI,8CI,9CI)

2,4-Dichloropyrimidine, GC 97%

2,4-Dichloropyrimidine ,97%

2,4-dichloropyrimidine hydrochloride

2,4-Dichloropyrimidi

4-DichloropyriMidine

2,4-Dichloro-1,3-diazine

2,4-DichloropyriMidine, 97% 25GR

2-ChloropyriMidin-4-yl Chloride

NSC 20212

NSC 37531

NSC 49119

2,4-Dichloropyrimidine, 97%, for synthesis

2,4-Dichloropyrimidine&gt

Pazopanib Impurity 45

2,4-dichloro pyrimidine( 2,4-DCP)

2-naphthalen-5-ylethanamine

2,4-dichloro pyrimdine

2,4-Dichloropyrimidine / Osimertinib intermediate

DichloroPyrimidine-2,4

2,4-Dichioropyrimidine

Pyridine-7-one 2,4-dichloropyrimidine

3934-20-1

C4H2N2Cl2

C4H2Cl2N2

C4H2N2CI2

Building Blocks

Heterocyclic Building Blocks

Halogenated Heterocycles

Pyrimidines

HETERO CHLORIDE

Building Blocks

Halogenated Heterocycles

Heterocyclic Building Blocks

PyrimidinesHeterocyclic Building Blocks

Heterocyclic Compounds

Building Blocks

Aromatics Compounds

Pyrimidines

Pyrimidine Series

Pyridines, Pyrimidines, Purines and Pteredines

Halides

Pyrazines, Pyrimidines & Pyridazines

Aromatics

Heterocycles

Pyrazines, Pyrimidines & Pyridazines

Heterocycle-Pyrimidine series

PYRIMIDINE