1-Ethylpiperidine Property

Melting point:

-20 °C

Boiling point:

131 °C(lit.)

Density 

0.824 g/mL at 25 °C(lit.)

vapor pressure 

12.76hPa at 20℃

refractive index 

n20/D 1.444(lit.)

Flash point:

66 °F

storage temp. 

Flammables area

solubility 

1-ethylpiperidine salt of benzylpenicillin is considerably less soluble in amyl acetate and acetone.

pka

10.45(at 23℃)

form 

Liquid

color 

Clear colorless to slightly yellow

PH

12.2 (50g/l, H2O, 20℃)

explosive limit

1.9-12.1%(V)

Water Solubility 

50 G/L

BRN 

102643

LogP

1.89 at 25℃

CAS DataBase Reference

766-09-6(CAS DataBase Reference)

NIST Chemistry Reference

Piperidine, 1-ethyl-(766-09-6)

EPA Substance Registry System

Piperidine, 1-ethyl- (766-09-6)

Safety

Hazard Codes 

F,Xn

Risk Statements 

11-20/22-36/37/38

Safety Statements 

26-36/37/39

RIDADR 

UN 2386 3/PG 2

WGK Germany 

1

RTECS 

TN0250000

F 

10-23

TSCA 

Yes

HazardClass 

3

PackingGroup 

II

HS Code 

29333990

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H312Harmful in contact with skin

H314Causes severe skin burns and eye damage

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

1-Ethylpiperidine Chemical Properties,Usage,Production

Chemical Properties

CLEAR COLOURLESS TO SLIGHTLY YELLOWISH LIQUID

Uses

Reactant for: Synthesis of multiprotected kanosamine1 Selective acylation in peptide synthesis2Reagent for: Stereoselective aldol condensation reactions for synthesis of β-lactam antibiotics3 Diastereoselective synthesis of aldols4 Crossed Claisen ester condensation5

Uses

In Room temperature phosphorescence of α-bromonaphthalene induced by cyclodextrin in the presence of hexahydropyridine or 1-ethylpiperidine and its application is described. The highest yields of 5-Bromopyrimidine (37%) were obtained by using 1-ethylpiperidine or triethylamine as condensing agent. Tributyltin hydride and 1-ethylpiperidine hypophosphite were mediated intermolecular radical additions to 2, 4, 6-trichlorophenyl vinyl sulfonate.

Definition

ChEBI: N-ethylpiperidine is a member of piperidines.

Synthesis Reference(s)

Organic Syntheses, Coll. Vol. 5, p. 575, 1973
The Journal of Organic Chemistry, 28, p. 3259, 1963 DOI: 10.1021/jo01046a537

General Description

A colorless liquid with the odor of pepper. Less dense than water. Flash point 66°F. May irritate skin and eyes. Vapors heavier than air. Used as a solvent and to make other chemicals.

Air & Water Reactions

Highly flammable. Soluble in water.

Reactivity Profile

1-Ethylpiperidine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Health Hazard

May cause toxic effects if inhaled or ingested/swallowed. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

Fire Hazard

Flammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Flammability and Explosibility

Highly flammable

Safety Profile

Poison by intravenous and subcutaneous routes. An eye irritant. A very dangerous fire hazard when exposed to heat or flame; can react vigorously with oxidizing materials. When heated to decomposition it emits toxic fumes of Nox.