Six-membered heterocyclic compounds Chemical properties Uses Pyrimidine base The functions of purine, pyrimidine and other substances Preparation Fluorouracil
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Pyrimidine

Six-membered heterocyclic compounds Chemical properties Uses Pyrimidine base The functions of purine, pyrimidine and other substances Preparation Fluorouracil
Product Name
Pyrimidine
CAS No.
289-95-2
Chemical Name
Pyrimidine
Synonyms
Pyrimidin;1,3-DIAZINE;Metadiazine;2,4,6-TRICHLORO-5-FLUOROPYRIMIDINE;2,4,6-trichloro-5-formylpyrimidine;iazine;Miazine;m-Diazine;PYRIMIDINE;1,3-Diazin
CBNumber
CB6224079
Molecular Formula
C4H4N2
Formula Weight
80.09
MOL File
289-95-2.mol
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Pyrimidine Property

Melting point:
19-22 °C (lit.)
Boiling point:
123-124 °C (lit.)
Density 
1.016 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.504(lit.)
Flash point:
88 °F
storage temp. 
Flammables area
solubility 
soluble
form 
Liquid
pka
1.23(at 20℃)
color 
Clear colorless to orange
Water Solubility 
soluble
Sensitive 
Hygroscopic
Merck 
14,7987
BRN 
103894
Stability:
Stable, but air-sensitive and hygroscopic. Incompatible with acids, acid chlorides, acid anhydrides, strong oxidizing agents, carbon dioxide. Flammable.
CAS DataBase Reference
289-95-2(CAS DataBase Reference)
NIST Chemistry Reference
1,3-Diazine(289-95-2)
EPA Substance Registry System
Pyrimidine (289-95-2)
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Safety

Risk Statements 
10
Safety Statements 
23-24/25-16
RIDADR 
UN 1993 3/PG 3
WGK Germany 
3
RTECS 
UV6263000
TSCA 
Yes
HazardClass 
3
PackingGroup 
III
HS Code 
29335990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H226Flammable liquid and vapour

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
131695
Product name
Pyrimidine
Purity
≥98.0%
Packaging
1g
Price
$45.8
Updated
2024/03/01
Sigma-Aldrich
Product number
131695
Product name
Pyrimidine
Purity
≥98.0%
Packaging
5g
Price
$124
Updated
2024/03/01
TCI Chemical
Product number
P0662
Product name
Pyrimidine free base
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$33
Updated
2024/03/01
TCI Chemical
Product number
P0662
Product name
Pyrimidine free base
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$91
Updated
2024/03/01
Alfa Aesar
Product number
A15534
Product name
Pyrimidine, 99%
Packaging
1g
Price
$31.65
Updated
2024/03/01
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Pyrimidine Chemical Properties,Usage,Production

Six-membered heterocyclic compounds

Pyridine, also known as "metadiazine", is a six-membered heteroaromatic ring compound containing two nitrogen atoms in the meta-position, being isomers with pyridazine and pyrazine. It has a molecular formula of C4H4N2 with the molecular weight being 80.09. It appears as colorless liquid or solid crystals with a pungent odor. It has a melting temperature of 20~22 ℃, boiling point of 123~124 °C and refractive index of 1.4998 (20 °C). It is easily soluble in water, ethanol and ether with weak alkaline and being capable of forming salts with acid. Its alkalinity is weaker than pyridine. It is also more difficult for it to participate into electrophilic substitution reaction than pyridine. It can only undergo bromination at the 5th position and is not capable of having nitrification and sulfonation reaction, but more prone to participate into nucleophilic substitution. Pyrimidine derivatives are widely found in nature. For example, vitamin B1, uracil, cytosine and thymine all contain pyrimidine structure. Its picrate salt appears as yellow needle-like crystals. It has a melting temperature of 156 °C. Owing to the presence of conjugated double bonds in the structure, pyrimidine has strong absorption capability on ultraviolet light. It is manufactured through phosphorus oxychloride oxidation of barbituric acid, followed by reduction through hydrogen iodide.
Nucleic acid contains three important pyrimidine derivatives, being an important base in nucleic acid, plays an important role in the body of organisms.

DNA mainly contains cytosine and thymine while RNA mainly contains cytosine and uracil, in some nucleic acids, there are also small amount of pyrimidine modified base, for example:

Sulfadiazine and its derivatives are commonly used antibacterial anti-inflammatory drugs.
The above information is edited by Andy Edwards of Chemicalbook.

Chemical properties

It appears as colorless crystalline or liquid.

Uses

Pyrimidine is a heterocyclic organic molecule found in numerous pharmaceutical and naturally occurring compounds. It plays a significant role in the synthesis and discovery of antiviral medications, including those targeting HIV and HSV. Additionally, pyrimidine is involved in the synthesis of potent 15-lipoxygenase inhibitors that help reduce the release of leukotrienes. While pyrimidine itself has no direct applications, its derivatives, cytosine, uracil, and thymine, are essential components of nucleic acids. Various drugs, such as sulfadiazine, trimethoprim, and 6-mercaptopurine, also contain a pyrimidine ring.

Pyrimidine base

Pyrimidine base is one of the chemical compositions of the nucleotides. It consists of carbon, nitrogen, hydrogen, oxygen and other elements. Pyrimidine bases include uracil, cytosine, and thymine, where uracil and cytosine constitute the bases in ribonucleic acid molecules while thymine and cytosine constitute bases in deoxyribonucleic acid molecules. Pyrimidine base has a strong absorption on ultraviolet in the wavelength of 250~280nm. The raw materials for its synthesis are derived from carbamoyl phosphate and aspartic acid. Pyrimidine base can also be metabolized into carbon dioxide, β-alanine and β amino-isobutyric acid and other substances. Some patients, due to congenital factors or taking certain drugs, can get pyrimidine alkali metabolic disorders, causing whey aciduria.

The functions of purine, pyrimidine and other substances

Purines and pyrimidines are essential heterocyclic nitrogen-containing compounds that used in nucleic acid metabolism in organisms (including humans) and are important substances in the formation of ribonucleic acid and deoxyribonucleic acid in cells. Purine, pyrimidine and ribose and phosphate can combine to form RNA; purine, pyrimidine and deoxyribose can bind to phosphate to produce DNA. DNA is the main chemical constituent of genes, which plays an important role in the transmission of genes (genetics); the main function of RNA is the regulation of intracellular protein synthesis. The final product of purine metabolism is mainly uric acid. Barley and malt contains 0.2% to 0.3% of the dry matter of nucleic acid. Upon the saccharification, the dry matter of nucleic acid can be subject to the degradation of various phosphatases to form nucleotides, nucleosides, purines and pyrimidine and many other degradation products, of which only purine and pyrimidine can enter into yeast cells to constitute ribonucleic acid, deoxyribonucleic acid, adenosine triphosphate and some coenzymes. Nucleotides are difficult to be absorbed. If the medium is lack of purine and pyrimidine, the cells have to rely on carbohydrates and amino acids for synthesis, thus consuming a lot of energy and influence the proliferation of yeast. In general, wort is not lack of the required purine and pyrimidine.
References: Chinese Medical Encyclopedia Editorial Board Editor; Guo Di editor in chief. Chinese Encyclopedia of Medicine • fifty-seven pediatrics.

Preparation

1, take malondialdehyde and formamide as raw materials and have reaction upon heating; we can obtain pyrimidine.
2, it can be manufactured through the catalytic hydrogenation of 2, 4-dichloropyrimidine in the system.
3, use zinc powder to reduce 2, 4, 6-trichloropyrimidine, pyrimidine can be obtained.
4, the reaction between ethyl acetoacetate and amidine (below) can produce pyrimidine.

Fluorouracil

Fluorouracil is a pyrimidine antimetabolite. In the body, it is first converted into 5-fluoro-2-deoxyuridine nucleotides (FUdRP), causing inhibition of thymidylate synthase (TMPS), preventing the conversion of deoxyuridine nucleotide into thymidine, interfering with DNA synthesis and leading to cell damage and death. It has a stronger effect in the presence of leucovorin (CF) because FUdRP, FH4 and TMPS can form triple complexes making the active metabolite of drug bind more tightly with the enzyme, so addition of CF when applying will yield better efficacy, especially improving the efficacy upon being applied to colorectal cancer. This product is cell cycle-specific drugs with killing effects on proliferated cells at all stages. It is most sensitive to the S phase, and also has retardation effect on the G1/S border. Oral absorption is not complete, and the drug is easily inactivated upon liver metabolism. After intravenous infusion or arterial infusion, the blood concentration is relatively stable.
Fluorouracil has relative significant effect against choriocarcinoma and malignant mole. It also has certain curative effects on gastric cancer, colon cancer, rectum cancer, liver cancer, pancreatic cancer, breast cancer, ovarian cancer, cervical cancer, prostate cancer, bladder cancer, kidney cancer, lung cancer, head and neck cancer and skin cancer.

Chemical Properties

Colourless to pale yellow liquid

Uses

Pyrimidine is used as building block in chemical synthesis. Product Data Sheet

Uses

Pyrimidine was used to assess the extent of pyrimidine/purine asymmetry quantitatively. It was also used to study the photoinduced ion chemistry of the halogenated pyrimidines, a class of prototype radiosensitizing molecules.

Definition

ChEBI: Pyrimidine is a simple nitrogenous organic molecule whose ring structure is contained in the pyrimidine bases cytosine, thymine, and uracil, which are constituents of the nucleic acids. It has a role as a Daphnia magna metabolite. It is a member of pyrimidines and a diazine.

Pyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

4-Aminopyrimidine
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View Lastest Price from Pyrimidine manufacturers

HebeiShuoshengImportandExportco.,Ltd
Product
Pyrimidine 289-95-2
Price
US $6.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000KG/Month
Release date
2024-08-08
Hebei Longbang Technology Co., Ltd
Product
Pyrimidine 289-95-2
Price
US $6.00/kg
Min. Order
1kg
Purity
More than 99%
Supply Ability
2000KG/Month
Release date
2024-04-29
Hebei Jingbo New Material Technology Co., Ltd
Product
Pyrimidine 289-95-2
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1000000
Release date
2023-12-20

289-95-2, PyrimidineRelated Search:

Thymine Uracil 2-Pyrimidinecarboxamide (6CI,7CI,9CI) Pyrimidine-5-boronic acid pinacol ester Pyrimidine-2-carboxylic acid 5-Pyrimidinecarboxylic acid PYRIMIDINE-4-CARBOXALDEHYDE Pyrimidine-5-carboxaldehyde Pyrrole-2-carboxaldehyde PYRROLE-2-CARBONITRILE Pyrrole-2-carboxylic acid Fluorocytosine Cytosine 2-Amino-6-chloropurine-9-riboside 8-BROMOADENOSINE 2,6-Dichloropurine 6-Benzylaminopurine 2-Chloroadenosine

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