ChemicalBook > CAS DataBase List > Amino-PEG2-acid

Amino-PEG2-acid

Product Name: Amino-PEG2-acid
CAS No.: 791028-27-8
Chemical Name: Amino-PEG2-acid
Synonyms: NH2-PEG2-COOH;H2N-PEG2-CH2CH2COOH;Amino-PEG2-C2-acid;Amino-PEG2-COOH;AMINE-PEG2-COOH;Amino-PEG2-acid;Amino-PEG2-propionic acid;H2N-(CH2CH2O)2-CH2CH2COOH;α-amine-ω-propionic acid diethylene glycol;3-[2-(2-Aminoethoxy)ethoxy]-propanoic acid
CBNumber: CB62501433
Molecular Formula: C7H15NO4
Formula Weight: 177.2
MOL File: 791028-27-8.mol

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Amino-PEG2-acid Property

Boiling point:: 331.5±27.0 °C(Predicted)
Density: 1.142±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: soluble in water
pka: 4.27±0.10(Predicted)
form: Solid
color: White to off-white
Appearance: white to off-yellow powder
InChI: InChI=1S/C7H15NO4/c8-2-4-12-6-5-11-3-1-7(9)10/h1-6,8H2,(H,9,10)
InChIKey: DEZXLFKSYRODPB-UHFFFAOYSA-N
SMILES: C(O)(=O)CCOCCOCCN

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Safety

HS Code: 2918999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: A577183
Product name: Amino-PEG2Acid
Packaging: 10mg
Price: $45
Updated: 2021/12/16

TRC

Product number: A577183
Product name: Amino-PEG2Acid
Packaging: 100mg
Price: $130
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FP73006
Product name: 3-(2-(2-Aminoethoxy)ethoxy)-propanoic acid
Packaging: 50mg
Price: $50
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FP73006
Product name: 3-(2-(2-Aminoethoxy)ethoxy)-propanoic acid
Packaging: 100mg
Price: $80
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FP73006
Product name: 3-(2-(2-Aminoethoxy)ethoxy)-propanoic acid
Packaging: 250mg
Price: $160
Updated: 2021/12/16

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Amino-PEG2-acid Chemical Properties,Usage,Production

Description

Amino-PEG2-acid is a PEG reagent containing an amino group with a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Uses

Amino-PEG2-C2-acid is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-PEG2-C2-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Biological Activity

Amino-PEG2-C2-acid is a cleavable 3-unit PEG ADClinker for the synthesis of antibody-drug conjugated Ck (ADC). It is also a PEG-based PROTAClinker that can be used for PROTAC synthesis.

in vivo

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

IC 50

Cleavable Linker; PEGs

References

[1] Antibody drug conjugate, intermediate, preparation method, pharmaceutical composition and uses thereof. WO2016197946A1.

Amino-PEG2-acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Amino-PEG2-acid manufacturers

LAURENT

Product: NH2-PEG2-CH2CH2COOH 791028-27-8
Price: US $113.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 300kg
Release date: 2025-11-17

airuikechemical co., ltd.

Product: α-amine-ω-propionic acid diethylene glycol 791028-27-8
Price: US $0.00-0.00/Kg
Min. Order: 1Kg
Purity: 99.9%
Supply Ability: 200tons
Release date: 2024-04-08

Xian confluore Biological Technology Co., Ltd.

Product: Amino-PEG2-COOH 791028-27-8
Price: US $0.00/mg
Min. Order: 250mg
Purity: >98.00%
Supply Ability: 250mg
Release date: 2024-03-22

791028-27-8, Amino-PEG2-acidRelated Search:

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α-amine-ω-propionic acid diethylene glycol

alpha-aMine-oMega-propionic acid diethylene glycol

H2N-PEG2-CH2CH2COOH

3-[2-(2-Aminoethoxy)ethoxy]-propanoic acid

Amino-PEG2-acid

NH2-PEG2-COOH

Amino-PEG2-propionic acid

H2N-PEG2-CH2CH2COOH

AMINE-PEG2-COOH

Amino-PEG2-COOH

Amino-PEG2-C2-acid

Propanoic acid, 3-[2-(2-aminoethoxy)ethoxy]-

H2N-(CH2CH2O)2-CH2CH2COOH

H2N-PEG2-CH2CH2COOH/Propanoic acid, 3-[2-(2-aminoethoxy)ethoxy]-

α-amine-ω-propionic acid diethylene glycol

791028-27-8

PEG-COOtBu

ADCs Linkers

peg