Amino-PEG2-acid
- Product Name
- Amino-PEG2-acid
- CAS No.
- 791028-27-8
- Chemical Name
- Amino-PEG2-acid
- Synonyms
- NH2-PEG2-COOH;H2N-PEG2-CH2CH2COOH;Amino-PEG2-C2-acid;Amino-PEG2-COOH;AMINE-PEG2-COOH;Amino-PEG2-acid;Amino-PEG2-propionic acid;H2N-(CH2CH2O)2-CH2CH2COOH;Α-AMINE-Ω-PROPIONIC ACID DIETHYLENE GLYCOL;3-[2-(2-Aminoethoxy)ethoxy]-propanoic acid
- CBNumber
- CB62501433
- Molecular Formula
- C7H15NO4
- Formula Weight
- 177.2
- MOL File
- 791028-27-8.mol
Amino-PEG2-acid Property
- Boiling point:
- 331.5±27.0 °C(Predicted)
- Density
- 1.142±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 4.27±0.10(Predicted)
Safety
- HS Code
- 2918999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A577183
- Product name
- Amino-PEG2Acid
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- A577183
- Product name
- Amino-PEG2Acid
- Packaging
- 100mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- FP73006
- Product name
- 3-(2-(2-Aminoethoxy)ethoxy)-propanoic acid
- Packaging
- 250mg
- Price
- $160
- Updated
- 2021/12/16
- Product number
- FP73006
- Product name
- 3-(2-(2-Aminoethoxy)ethoxy)-propanoic acid
- Packaging
- 50mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- FP73006
- Product name
- 3-(2-(2-Aminoethoxy)ethoxy)-propanoic acid
- Packaging
- 100mg
- Price
- $80
- Updated
- 2021/12/16
Amino-PEG2-acid Chemical Properties,Usage,Production
Description
Amino-PEG2-acid is a PEG reagent containing an amino group with a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
Biological Activity
Amino-PEG2-C2-acid is a cleavable 3-unit PEG ADClinker for the synthesis of antibody-drug conjugated Ck (ADC). It is also a PEG-based PROTAClinker that can be used for PROTAC synthesis.
in vivo
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
Amino-PEG2-acid Preparation Products And Raw materials
Raw materials
Preparation Products
Amino-PEG2-acid Suppliers
View Lastest Price from Amino-PEG2-acid manufacturers
- Product
- α-amine-ω-propionic acid diethylene glycol 791028-27-8
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1Kg
- Purity
- 99.9%
- Supply Ability
- 200tons
- Release date
- 2024-04-08
- Product
- Amino-PEG2-COOH 791028-27-8
- Price
- US $0.00/mg
- Min. Order
- 250mg
- Purity
- >98.00%
- Supply Ability
- 250mg
- Release date
- 2024-03-22
- Product
- α-amine-ω-propionic acid diethylene glycol 791028-27-8
- Price
- US $8.80/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 100kg
- Release date
- 2019-07-04