N-(4-Chloro-3-methoxyphenyl)-2-pyridinecarboxamide

ChemicalBook > CAS DataBase List > N-(4-Chloro-3-methoxyphenyl)-2-pyridinecarboxamide

N-(4-Chloro-3-methoxyphenyl)-2-pyridinecarboxamide

Product Name: N-(4-Chloro-3-methoxyphenyl)-2-pyridinecarboxamide
CAS No.: 1161205-04-4
Chemical Name: N-(4-Chloro-3-methoxyphenyl)-2-pyridinecarboxamide
Synonyms: ML128;CS-626;PBLJ9653;VU 0361737;CID-44191096;VU0361737(ML128);VU 0361737, >98%;N-(4-CHLORO-3-METHOXYPHENYL)PICOLINAMIDE;1-(3,4-DICHLOROBENZYL)INDOLINE-2,3-DIONE;VU 0361737;ML-128; VU-0361737; VU 0361737
CBNumber: CB62518798
Molecular Formula: C13H11ClN2O2
Formula Weight: 262.69
MOL File: 1161205-04-4.mol

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N-(4-Chloro-3-methoxyphenyl)-2-pyridinecarboxamide Property

storage temp.: Inert atmosphere,2-8°C
solubility: DMSO: soluble15mg/mL (clear solution)
form: film
color: white

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Safety

Hazard Codes: Xn
Risk Statements: 22-36
Safety Statements: 26
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0494
Product name: VU0361737
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $296
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0494
Product name: VU0361737
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $80.4
Updated: 2022/05/15

Cayman Chemical

Product number: 16295
Product name: VU0361737
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 16295
Product name: VU0361737
Purity: ≥98%
Packaging: 5mg
Price: $70
Updated: 2024/03/01

Cayman Chemical

Product number: 16295
Product name: VU0361737
Purity: ≥98%
Packaging: 10mg
Price: $109
Updated: 2024/03/01

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N-(4-Chloro-3-methoxyphenyl)-2-pyridinecarboxamide Chemical Properties,Usage,Production

Uses

VU0361737 is an mGluR4-specific positive allosteric modulator (PAM).

Biological Activity

vu0361737 is a selective, positive allosteric modulator and brain-permeable for mglur4 (mglu4 receptor), (ec₅₀ = 240 and 110 nm for human and rat receptors respectively), >50 fold selectivity over other mglur subtypes. inactive at mglur-1, mglur-2, mglur-3, mglur-6 and mglur-7 receptors and showed weak activity at mglur-5 and mglur-8 receptors. [1]the mglur (metabotropic glutamate receptor) is a group of g-protein coupled receptors and is active through an indirect metabotropic process. mglur4 are invoinved in parkinson as it decrease gabaerigic transmission at inhibitory striato-pallidal synapse with the basal ganglia.[1][2]following the administration of vu0361737 into rat intraperitoneally (10mg/kg), the amount of compound present in brain and plasma was determined at 0.5, 1 and 8 hours. it showed a short half-life (t1/2 20 minutes) and a pronounced brain exposure (brain: plasma ratio = 4.1) [1]

storage

Room temperature

References

[1] engers dw, niswender cm, weaver cd, jadhav s, menon un, zamorano r, conn pj, lindsley cw, hopkins cr. synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mglur4) positive allosteric modulators (pams). j med chem. 2009 jul 23;52(14):4115-8.
[2] engers dw, field jr, le u, zhou y, bolinger jd, zamorano r, blobaum al, jones ck, jadhav s, weaver cd, conn pj, lindsley cw, niswender cm, hopkins cr. discovery, synthesis, and structure-activity relationship development of a series of n-(4-acetamido)phenylpicolinamides as positive allosteric modulators of metabotropic glutamate receptor 4 (mglu(4)) with cns exposure in rats. j med chem. 2011 feb 24;54(4):1106-10.

N-(4-Chloro-3-methoxyphenyl)-2-pyridinecarboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from N-(4-Chloro-3-methoxyphenyl)-2-pyridinecarboxamide manufacturers

Career Henan Chemical Co

Product: N-(4-Chloro-3-methoxyphenyl)-2-pyridinecarboxamide 1161205-04-4
Price: US $5.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1ton
Release date: 2019-09-03

1161205-04-4, N-(4-Chloro-3-methoxyphenyl)-2-pyridinecarboxamideRelated Search:

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N-(4-Chloro-3-methoxyphenyl)-2-pyridinecarboxamide

VU 0361737

1-(3,4-DICHLOROBENZYL)INDOLINE-2,3-DIONE

N-(4-CHLORO-3-METHOXYPHENYL)PICOLINAMIDE

2-Pyridinecarboxamide, N-(4-chloro-3-methoxyphenyl)-

CID-44191096

ML128

VU 0361737;ML-128; VU-0361737; VU 0361737

CS-626

VU0361737(ML128)

ML-128; VU-0361737; VU 0361737;ML128;ML 128

VU 0361737, >98%

N-(4-Chloro-3-methoxyphenyl)pyridine-2-carboxamide

N-(4-Chloro-3-methoxyphenyl)-2-pyridinecarboxamide USP/EP/BP

PBLJ9653

1161205-04-4

C13H11CIN2O2

Inhibitors