3-Hydroxy-4-methoxybenzonitrile

Product Name: 3-Hydroxy-4-methoxybenzonitrile
CAS No.: 52805-46-6
Chemical Name: 3-Hydroxy-4-methoxybenzonitrile
Synonyms: Benzonitrile, 3-hydroxy-4-Methoxy-;ISOVANILLONITRILE;CBI-BB ZERO/005397;2-methoxy-5-cyanophenol;5-Cyano-2-methoxyphenol;3-Hydroxy-4-methoxybenzonitril;3-HYDROXY-4-METHOXYBENZONITRILE;3-Hydroxy-4-methoxy benzonitrile 95+%;3-Hydroxy-4-methoxybenzonitrile ISO 9001：2015 REACH;3-HYDROXY-4-METHOXYBENZONITRILE (ISOVANILLONITRILE)
CBNumber: CB6287199
Molecular Formula: C8H7NO2
Formula Weight: 149.15
MOL File: 52805-46-6.mol

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3-Hydroxy-4-methoxybenzonitrile Property

Melting point:: 124 °C
Boiling point:: 300.8±27.0 °C(Predicted)
Density: 1.24±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
pka: 8.59±0.10(Predicted)
Appearance: White to off-white Solid
CAS DataBase Reference: 52805-46-6(CAS DataBase Reference)

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Safety

HS Code: 29269090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: H972653
Product name: 3-Hydroxy-4-methoxybenzonitrile
Packaging: 100mg
Price: $45
Updated: 2021/12/16

AK Scientific

Product number: J53639
Product name: 3-Hydroxy-4-methoxybenzonitrile
Packaging: 1g
Price: $10
Updated: 2021/12/16

Matrix Scientific

Product number: 074666
Product name: 3-Hydroxy-4-methoxybenzonitrile
Purity: 95+%
Packaging: 5g
Price: $32
Updated: 2021/12/16

ChemScene

Product number: CS-W002933
Product name: 3-Hydroxy-4-methoxybenzonitrile
Purity: 99.87%
Packaging: 25g
Price: $36
Updated: 2021/12/16

Apolloscientific

Product number: OR345595
Product name: 3-Hydroxy-4-methoxybenzonitrile
Purity: 95+%
Packaging: 25g
Price: $70
Updated: 2021/12/16

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3-Hydroxy-4-methoxybenzonitrile Chemical Properties,Usage,Production

Synthesis

621-59-0

52805-46-6

The general procedure for synthesizing 3-hydroxy-4-methoxybenzonitrile from isovanillin was as follows: 14.2 g of isovanillin was dissolved in 75 mL of formic acid, 15 g of sodium formate was added, and stirred at 85 °C. Subsequently, 9 g of hydroxylamine hydrochloride was added in batches, and the reaction mixture was kept at 85 °C and continued to be stirred for 4 hours. Upon completion of the reaction, the mixture was poured into a nearly saturated sodium chloride solution and a precipitate was precipitated. The precipitate was separated by filtration, washed sequentially with water and petroleum ether, and dried to give the product. The yield was 14.2 g. The yield was 93% of the theoretical value. The product was analyzed by HPLC-MS (Method D) with a retention time (Rt) of 1.18 min.

References

[1] Patent: WO2011/92128, 2011, A1. Location in patent: Page/Page column 37
[2] Patent: US2012/28939, 2012, A1. Location in patent: Page/Page column 18
[3] Patent: CN105330586, 2016, A. Location in patent: Paragraph 0055; 0056
[4] Patent: CN105461602, 2016, A. Location in patent: Paragraph 0049; 0050
[5] Molecules, 2017, vol. 22, # 10,

3-Hydroxy-4-methoxybenzonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Hydroxy-4-methoxybenzonitrile Suppliers

China 185 Europe 2 Germany 1 India 10 Russia 1 Switzerland 1 United Kingdom 5 United States 18 Global 223

Apollo Scientific Ltd.

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Eurolabs Limited

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Apin Chemicals Ltd.

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View Lastest Price from 3-Hydroxy-4-methoxybenzonitrile manufacturers

Career Henan Chemical Co

Product: 3-Hydroxy-4-methoxybenzonitrile 52805-46-6
Price: US $8.80/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 100kg
Release date: 2019-07-12

Career Henan Chemical Co

Product: 3-Hydroxy-4-methoxybenzonitrile 52805-46-6
Price: US $8.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 100KG
Release date: 2018-12-15

52805-46-6, 3-Hydroxy-4-methoxybenzonitrileRelated Search:

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ISOVANILLONITRILE

CBI-BB ZERO/005397

Benzonitrile, 3-hydroxy-4-Methoxy-

3-HYDROXY-4-METHOXYBENZONITRILE

3-HYDROXY-4-METHOXYBENZONITRILE (ISOVANILLONITRILE)

3-Hydroxy-4-methoxybenzonitril

5-Cyano-2-methoxyphenol

Gefitinib IMpurity (3-Hydroxy-4-Methoxybenzonitrile)

3-Hydroxy-4-methoxy benzonitrile 95+%

3-Hydroxy-4-methoxybenzonitrile ISO 9001：2015 REACH

2-methoxy-5-cyanophenol

52805-46-6

Gefitinib

Aromatic Nitriles

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