ChemicalBook > CAS DataBase List > 5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE

5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE

Product Name: 5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE
CAS No.: 42518-98-9
Chemical Name: 5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE
Synonyms: 5-Chorothiophene-2-carbonyl chloride;2-thiophenecarbonyl chloride, 5-chloro-;2-Amino-10-picoline;Rivaroxabansidechain;Rivaroxaban Impurity 82;orothiophene-2-carbonyL;Rivaroxaban Impurity 102;Rivaroxaban Impurity 103;5-Chloro-2-thenoyl Chloride;5-Chlorothieno-2-formyl chloride
CBNumber: CB6290784
Molecular Formula: C5H2Cl2OS
Formula Weight: 181.04
MOL File: 42518-98-9.mol

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5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE Property

Melting point:: 4℃
Boiling point:: 122-127℃/16Torr
Density: 1.50
refractive index: 1.6040 to 1.6080
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Oil
color: Colourless to Pale Yellow
Water Solubility: Slightly soluble in water.
Sensitive: Moisture Sensitive
Stability:: Hygroscopic
InChI: InChI=1S/C5H2Cl2OS/c6-4-2-1-3(9-4)5(7)8/h1-2H
InChIKey: BMPDCQVRKDNUAP-UHFFFAOYSA-N
SMILES: C(Cl)(C1SC(Cl)=CC=1)=O
CAS DataBase Reference: 42518-98-9(CAS DataBase Reference)

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Safety

Risk Statements: 36-43
Safety Statements: 26-36
RIDADR: 3265
HazardClass: IRRITANT
HazardClass: 8
PackingGroup: Ⅲ
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

H318Causes serious eye damage

Precautionary statements

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: C2864
Product name: 5-Chlorothiophene-2-carbonyl Chloride
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $28
Updated: 2025/07/31

TCI Chemical

Product number: C2864
Product name: 5-Chlorothiophene-2-carbonyl Chloride
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $84
Updated: 2025/07/31

TRC

Product number: C427825
Product name: 5-Chloro-2-ThiophenecarbonylChloride(>90%)
Packaging: 2.5g
Price: $110
Updated: 2021/12/16

TRC

Product number: C427825
Product name: 5-Chloro-2-ThiophenecarbonylChloride(>90%)
Packaging: 10g
Price: $275
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC42749
Product name: 5-Chlorothiophene-2-carbonyl chloride
Packaging: 10g
Price: $300
Updated: 2021/12/16

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5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE Chemical Properties,Usage,Production

Chemical Properties

Colorless to light yellow liquid

Uses

5-Chlorothiophene-2-carbonyl chloride used as a intermediate for rivaroxaban.

Synthesis

6310-09-4

42518-98-9

General procedure for the synthesis of 5-chloro-2-thiophene carbonyl chloride from 2-acetyl-5-chlorothiophene: To a mixed solution containing 2-acetyl-5-chlorothiophene (0.161 mg, 1.0 mmol), pyridine (0.012 mL, 0.15 mmol), and chlorobenzene (0.35 mL), at room temperature, disulfur dichloride (S2Cl2, 0.16 mL 2.0 mmol) with continuous stirring. After 2 hours of reaction, sulfuryl chloride (SO2Cl2, 0.121 mL, 1.5 mmol) was added dropwise and stirring was continued for 0.5 hours at room temperature. Subsequently, the reaction mixture was heated to 132 °C and stirred at this temperature for 15 hours. Upon completion of the reaction, the reaction mixture was diluted with deuterated chloroform (CDCl3, 2 mL) and an internal standard (tributyl phosphate, 1BU3PO4, 0.0552 mL, 0.20 mmol) was added for nuclear magnetic resonance (1H NMR) analysis.1H NMR analysis showed an 80% yield of 5-chloro-2-thiophene carbonyl chloride.1H NMR (PhCl. CDCl3, 400 MHz) chemical shift values: δ = 7.99 (d, J = 4 Hz, 1H), 6.86 (d, J = 4 Hz, 1H).

References

[1] Patent: WO2017/5606, 2017, A1. Location in patent: Page/Page column 33
[2] Patent: WO2016/150937, 2016, A1. Location in patent: Page/Page column 27
[3] Recueil des Travaux Chimiques des Pays-Bas, 1950, vol. 69, p. 1083,1103
[4] Journal of Organic Chemistry, 2015, vol. 80, # 20, p. 10370 - 10374
[5] Patent: WO2016/202757, 2016, A1. Location in patent: Page/Page column 30

5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE Preparation Products And Raw materials

Raw materials

2,5-Dichlorothiophene Sodium Diethyl ether Hydrochloric acid Thionyl chloride

Preparation Products

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5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE Suppliers

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View Lastest Price from 5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE manufacturers

Handan City Zechi trading Co., LTD

Product: 5-Chlorothiophene-2-carbonyl chloride 42518-98-9
Price: US $1.00/g
Min. Order: 100g
Purity: 99
Supply Ability: 1000
Release date: 2025-08-11

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

Product: 5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE 42518-98-9
Price: US $980.00-750.00/ton
Min. Order: 1ton
Purity: 99%
Supply Ability: 5000
Release date: 2024-08-15

Baoji Guokang Healthchem Co., Ltd.

Product: 5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE 42518-98-9
Price: US $365.00/Kg/Bag
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2021-06-05

42518-98-9, 5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDERelated Search:

(S)-(+)-Glycidyl Phthalimide 4-[4-(N-(3-chloro-(2R)-2-hydroxy-1-propyl)aMino)phenyl]Morpholin-3-one (S)-4-(4-(5-(Aminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one.HCl Ethyl (R)-(-)-4-cyano-3-hydroxybutyate 3-MORPHOLINONE, 4-[4-[(5S)-5-(AMINOMETHYL)-2-OXO-3-OXAZOLIDINYL]PHENYL]- 4-(4-AMINOPHENYL)MORPHOLIN-3-ONE 5-Chloro-2-thiophenecarboxylic Acid m-(Trifluoromethyl)phenylacetic acid 2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione 3-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE,3-Chlorothiophene-2-carbonyl chloride 98% 2-Chlorothiophene 2-Chloro-5-thiophenecarboxaldehyde 5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE 2-Chloro-5-chloromethylthiophene 2-(Chloromethyl)thiophene 2-Chloro-5-methylthiophene 3,4,5-TRICHLOROTHIOPHENE-2-CARBONYL CHLORIDE 2-Thiophenecarbonyl chloride

5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE

5-CHOROTHIOPHENE-2-ARBONYL CHLORIDE

5-Chlorothiophene-2-carbonyl chloride ,97%

2-Thiophenecarbonyl chloride, 5-chloro- (9CI)

5-Chorothiophene-2-carbonyl chloride

2-thiophenecarbonyl chloride, 5-chloro-

5-Chloro-2-thiophenecarbonyl chloride

2-Chloro-5-(chlorocarbonyl)thiophene, 2-Chloro-5-(chloroformyl)thiophene

5-Chlorothiophene-2-carbonyl chloride 97%

5-Chlorothiophiophene-2-Carbonyl Chloride

Rivaroxaban Impurity 82

Rivaroxabansidechain

5-Chlorothiophene-2-carbonyl Chloride &gt

orothiophene-2-carbonyL

5-Chloro-2-thenoyl Chloride

5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE ISO 9001：2015 REACH

5-Chloro-2-Thiophenecarbonyl Chloride (>90%)

2-Amino-10-picoline

Rivaroxaban Impurity 102

Rivaroxaban Impurity 103

5-Chloro-thiophen-2-carbonyl chloride

Rivaroxaban Impurity 95 ( 5-Chlorothiophene-2-carbonyl Chloride)

5-Chlorothiophene-2-formyl chloride

5-Chlorothieno-2-formyl chloride

5-Chlorothiaphene-2-carbonyl chloride

42518-98-9

ACIDHALIDE