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5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE

Product Name
5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE
CAS No.
42518-98-9
Chemical Name
5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE
Synonyms
5-Chorothiophene-2-carbonyl chloride;2-thiophenecarbonyl chloride, 5-chloro-;2-Amino-10-picoline;Rivaroxabansidechain;Rivaroxaban Impurity 82;orothiophene-2-carbonyL;Rivaroxaban Impurity 102;Rivaroxaban Impurity 103;5-Chloro-2-thenoyl Chloride;5-Chlorothieno-2-formyl chloride
CBNumber
CB6290784
Molecular Formula
C5H2Cl2OS
Formula Weight
181.04
MOL File
42518-98-9.mol
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5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE Property

Melting point:
4℃
Boiling point:
122-127℃/16Torr
Density 
1.50
refractive index 
1.6040 to 1.6080
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Oil
color 
Colourless to Pale Yellow
Water Solubility 
Slightly soluble in water.
Sensitive 
Moisture Sensitive
Stability:
Hygroscopic
InChI
InChI=1S/C5H2Cl2OS/c6-4-2-1-3(9-4)5(7)8/h1-2H
InChIKey
BMPDCQVRKDNUAP-UHFFFAOYSA-N
SMILES
C(Cl)(C1SC(Cl)=CC=1)=O
CAS DataBase Reference
42518-98-9(CAS DataBase Reference)
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Safety

Risk Statements 
36-43
Safety Statements 
26-36
RIDADR 
3265
HazardClass 
IRRITANT
HazardClass 
8
PackingGroup 
Ⅲ
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

H318Causes serious eye damage

Precautionary statements

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical
Product number
C2864
Product name
5-Chlorothiophene-2-carbonyl Chloride
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$28
Updated
2025/07/31
TCI Chemical
Product number
C2864
Product name
5-Chlorothiophene-2-carbonyl Chloride
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$84
Updated
2025/07/31
TRC
Product number
C427825
Product name
5-Chloro-2-ThiophenecarbonylChloride(>90%)
Packaging
2.5g
Price
$110
Updated
2021/12/16
TRC
Product number
C427825
Product name
5-Chloro-2-ThiophenecarbonylChloride(>90%)
Packaging
10g
Price
$275
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC42749
Product name
5-Chlorothiophene-2-carbonyl chloride
Packaging
10g
Price
$300
Updated
2021/12/16
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5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE Chemical Properties,Usage,Production

Chemical Properties

Colorless to light yellow liquid

Uses

5-Chlorothiophene-2-carbonyl chloride used as a intermediate for rivaroxaban.

Synthesis

6310-09-4

42518-98-9

General procedure for the synthesis of 5-chloro-2-thiophene carbonyl chloride from 2-acetyl-5-chlorothiophene: To a mixed solution containing 2-acetyl-5-chlorothiophene (0.161 mg, 1.0 mmol), pyridine (0.012 mL, 0.15 mmol), and chlorobenzene (0.35 mL), at room temperature, disulfur dichloride (S2Cl2, 0.16 mL 2.0 mmol) with continuous stirring. After 2 hours of reaction, sulfuryl chloride (SO2Cl2, 0.121 mL, 1.5 mmol) was added dropwise and stirring was continued for 0.5 hours at room temperature. Subsequently, the reaction mixture was heated to 132 °C and stirred at this temperature for 15 hours. Upon completion of the reaction, the reaction mixture was diluted with deuterated chloroform (CDCl3, 2 mL) and an internal standard (tributyl phosphate, 1BU3PO4, 0.0552 mL, 0.20 mmol) was added for nuclear magnetic resonance (1H NMR) analysis.1H NMR analysis showed an 80% yield of 5-chloro-2-thiophene carbonyl chloride.1H NMR (PhCl. CDCl3, 400 MHz) chemical shift values: δ = 7.99 (d, J = 4 Hz, 1H), 6.86 (d, J = 4 Hz, 1H).

References

[1] Patent: WO2017/5606, 2017, A1. Location in patent: Page/Page column 33
[2] Patent: WO2016/150937, 2016, A1. Location in patent: Page/Page column 27
[3] Recueil des Travaux Chimiques des Pays-Bas, 1950, vol. 69, p. 1083,1103
[4] Journal of Organic Chemistry, 2015, vol. 80, # 20, p. 10370 - 10374
[5] Patent: WO2016/202757, 2016, A1. Location in patent: Page/Page column 30

5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE Preparation Products And Raw materials

Raw materials

2,5-Dichlorothiophene Sodium Diethyl ether Hydrochloric acid Thionyl chloride

Preparation Products

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5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE Suppliers

Americas 1 China 298 Europe 2 Germany 1 India 17 Japan 1 Switzerland 1 United Kingdom 5 United States 17 Global 343
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28387
Advantage
80
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View Lastest Price from 5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE manufacturers

Handan City Zechi trading Co., LTD
Product
5-Chlorothiophene-2-carbonyl chloride 42518-98-9
Price
US $1.00/g
Min. Order
100g
Purity
99
Supply Ability
1000
Release date
2025-08-11
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE 42518-98-9
Price
US $980.00-750.00/ton
Min. Order
1ton
Purity
99%
Supply Ability
5000
Release date
2024-08-15
Baoji Guokang Healthchem Co., Ltd.
Product
5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE 42518-98-9
Price
US $365.00/Kg/Bag
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2021-06-05

42518-98-9, 5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDERelated Search:

(S)-(+)-Glycidyl Phthalimide 4-[4-(N-(3-chloro-(2R)-2-hydroxy-1-propyl)aMino)phenyl]Morpholin-3-one (S)-4-(4-(5-(Aminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one.HCl Ethyl (R)-(-)-4-cyano-3-hydroxybutyate 3-MORPHOLINONE, 4-[4-[(5S)-5-(AMINOMETHYL)-2-OXO-3-OXAZOLIDINYL]PHENYL]- 4-(4-AMINOPHENYL)MORPHOLIN-3-ONE 5-Chloro-2-thiophenecarboxylic Acid m-(Trifluoromethyl)phenylacetic acid 2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione 3-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE,3-Chlorothiophene-2-carbonyl chloride 98% 2-Chlorothiophene 2-Chloro-5-thiophenecarboxaldehyde 5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE 2-Chloro-5-chloromethylthiophene 2-(Chloromethyl)thiophene 2-Chloro-5-methylthiophene 3,4,5-TRICHLOROTHIOPHENE-2-CARBONYL CHLORIDE 2-Thiophenecarbonyl chloride

  • 5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE
  • 5-CHOROTHIOPHENE-2-ARBONYL CHLORIDE
  • 5-Chlorothiophene-2-carbonyl chloride ,97%
  • 2-Thiophenecarbonyl chloride, 5-chloro- (9CI)
  • 5-Chorothiophene-2-carbonyl chloride
  • 2-thiophenecarbonyl chloride, 5-chloro-
  • 5-Chloro-2-thiophenecarbonyl chloride
  • 2-Chloro-5-(chlorocarbonyl)thiophene, 2-Chloro-5-(chloroformyl)thiophene
  • 5-Chlorothiophene-2-carbonyl chloride 97%
  • 5-Chlorothiophiophene-2-Carbonyl Chloride
  • Rivaroxaban Impurity 82
  • Rivaroxabansidechain
  • 5-Chlorothiophene-2-carbonyl Chloride &gt
  • orothiophene-2-carbonyL
  • 5-Chloro-2-thenoyl Chloride
  • 5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE ISO 9001：2015 REACH
  • 5-Chloro-2-Thiophenecarbonyl Chloride (>90%)
  • 2-Amino-10-picoline
  • Rivaroxaban Impurity 102
  • Rivaroxaban Impurity 103
  • 5-Chloro-thiophen-2-carbonyl chloride
  • Rivaroxaban Impurity 95 ( 5-Chlorothiophene-2-carbonyl Chloride)
  • 5-Chlorothiophene-2-formyl chloride
  • 5-Chlorothieno-2-formyl chloride
  • 5-Chlorothiaphene-2-carbonyl chloride
  • 42518-98-9
  • ACIDHALIDE