Propargyl-PEG7-NHS ester

Product Name: Propargyl-PEG7-NHS ester
CAS No.: 2093152-77-1
Chemical Name: Propargyl-PEG7-NHS ester
Synonyms: Propargyl-PEG7-NHS ester;Propargyl-PEG6-CH2CH2COONHS;Propargyl-PEG6-C2-CONHS ester;Propyne heptapolyethylene glycol succinimide ester;2,5-Dioxopyrrolidin-1-yl 4,7,10,13,16,19,22-heptaoxapentacos-24-yn-1-oate;4,7,10,13,16,19,22-Heptaoxapentacos-24-ynoic acid, 2,5-dioxo-1-pyrrolidinyl ester;Propargyl-PEG6-CH2CH2COONHS/4,7,10,13,16,19,22-Heptaoxapentacos-24-ynoic acid, 2,5-dioxo-1-pyrrolidinyl ester
CBNumber: CB63373763
Molecular Formula: C22H35NO11
Formula Weight: 489.51
MOL File: 2093152-77-1.mol

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Propargyl-PEG7-NHS ester Property

Boiling point:: 562.7±60.0 °C(Predicted)
Density: 1.21±0.1 g/cm3(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-23458
Product name: Propargyl-PEG7-NHSester
Purity: 95%
Packaging: 100mg
Price: $280
Updated: 2021/12/16

Activate Scientific

Product number: AS107819
Product name: Propargyl-PEG6-CH2CH2COONHS
Purity: 97%
Packaging: 250mg
Price: $437
Updated: 2021/12/16

BroadPharm

Product number: BP-23458
Product name: Propargyl-PEG7-NHSester
Purity: 95%
Packaging: 500mg
Price: $650
Updated: 2021/12/16

BroadPharm

Product number: BP-23458
Product name: Propargyl-PEG7-NHSester
Purity: 95%
Packaging: 1g
Price: $950
Updated: 2021/12/16

Acrotein

Product number: B-1544
Product name: Propargyl-PEG6-CH2CH2COONHS
Purity: 97%
Packaging: 1g
Price: $660
Updated: 2021/12/16

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Propargyl-PEG7-NHS ester Chemical Properties,Usage,Production

Description

Propargyl-PEG7-NHS ester contains a propargyl group and an NHS ester. As an amine reactive reagent, this product can be used for derivatizing peptides, antibodies, amine coated surfaces etc. In the presence of copper catalyst, propargyl group reacts with azide to yield a stable triazole linkage. The PEG units help increase the hydrophilicity of the reagent.

Uses

Propargyl-PEG7-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG7-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Propargyl-PEG7-NHS ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC 50

Cleavable Linker; PEGs; Alkyl/ether

References

[1] Earl F Albone, et al. Eribulin-based antibody-drug conjugates and methods of use. US20170252458A1.

Propargyl-PEG7-NHS ester Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Propargyl-PEG7-NHS ester manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Propargyl-PEG7-NHS ester 2093152-77-1
Price: US $0.00/g
Min. Order: 1g
Purity: >98.00%
Supply Ability: 1g
Release date: 2024-03-26

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Propargyl-PEG7-NHS ester

Propargyl-PEG6-CH2CH2COONHS

4,7,10,13,16,19,22-Heptaoxapentacos-24-ynoic acid, 2,5-dioxo-1-pyrrolidinyl ester

2,5-Dioxopyrrolidin-1-yl 4,7,10,13,16,19,22-heptaoxapentacos-24-yn-1-oate

Propargyl-PEG6-C2-CONHS ester

Propargyl-PEG6-CH2CH2COONHS/4,7,10,13,16,19,22-Heptaoxapentacos-24-ynoic acid, 2,5-dioxo-1-pyrrolidinyl ester

Propyne heptapolyethylene glycol succinimide ester

2093152-77-1

C22H35NO11