2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl

ChemicalBook > CAS DataBase List > 2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl

2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl

Reaction

Product Name: 2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl
CAS No.: 213697-53-1
Chemical Name: 2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl
Synonyms: DAVEPHOS;2-(N,N-Dimethylamino)-2-(dicyclohexylphosphino)biphenyl;N-[2'-(dicyclohexylphosphino)-1,1'-biphenyl-2-yl]-N,N-diMethylaMine;Davep;2-(Dicycloh;98% DavePhos;DavePhos 97%;phosphino-2'-(N,N-dimethyL;2-Dicyclohexylphosphino-2'-(N,;2-DICYCLOHEXYLPHOSPHINO-2'-(N,N-DIMETHY&
CBNumber: CB6344872
Molecular Formula: C26H36NP
Formula Weight: 393.54
MOL File: 213697-53-1.mol

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2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl Property

Melting point:: 121-124 °C(lit.)
Boiling point:: 539.6±43.0 °C(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
pka: 5.04±0.18(Predicted)
form: crystal
color: white
Water Solubility: Insoluble
Sensitive: Air Sensitive
InChIKey: ZEMZPXWZVTUONV-UHFFFAOYSA-N
CAS DataBase Reference: 213697-53-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-22
Safety Statements: 26-36/37/39
WGK Germany: 3
TSCA: No
HazardClass: AIR SENSITIVE
HS Code: 29310099

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 638021
Product name: DavePhos
Purity: 97%
Packaging: 1g
Price: $31.88
Updated: 2024/03/01

Sigma-Aldrich

Product number: 638021
Product name: DavePhos
Purity: 97%
Packaging: 5g
Price: $137
Updated: 2024/03/01

TCI Chemical

Product number: D3389
Product name: 2-(Dicyclohexylphosphino)-2'-(dimethylamino)biphenyl
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $138
Updated: 2024/03/01

TCI Chemical

Product number: D3389
Product name: 2-(Dicyclohexylphosphino)-2'-(dimethylamino)biphenyl
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $415
Updated: 2024/03/01

Strem Chemicals

Product number: 15-1145
Product name: 2-(Dicyclohexylphosphino)-2'-(N,N-dimethylamino))-1,1'-biphenyl, 98% DavePhos
Packaging: 500mg
Price: $38
Updated: 2024/03/01

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2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl Chemical Properties,Usage,Production

Reaction

Ligand used in the Pd-catalyzed Suzuki coupling and animation of unactivated aryl chlorides. The reactions generally occur at room temperature and give high yields of product.
Ligand used in Pd-catalyzed C-N bond formation. A general synthesis of N6-aryl-2'deoxyadenosine analogues.
Ligand used in Pd-catalyzed N-arylation of indoles.
Ligand used in Pd-catalyzed synthesis of aryl-tert-butyl ethers.
Effective ligand in the Pd-catalyzed arylation of ester enolates.
Ligand employed in arylation of ketone enolates using ortho-halo nitrobenezenes.
Ligand employed in the amination of aryl nonaflates using Pd catalysts.
Ligand used for cascade alkenyl amination/Heck reaction for the synthesis of indoles.
Ligand used in Pd-catalyzed Kumada-Corriu cross coupling at low temperatures.
Ligand used in Rh-catalyzed intramolecular hydroamination of unactivated terminal and internal alkenes with primary and secondary amines.
Ligand used in Au-catalyzed cycloisomerization of allenes.

Description

2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl is a potent inhibitor of the enzyme bromodomain. Bromodomain has been implicated in cancer and other diseases. It binds to the bromodomain in a covalent manner, blocking the ATP site and inhibiting bromodomain function. This inhibition has been shown to be selective for bromodomains over other domains.

Chemical Properties

white to light yellow crystals or

Uses

suzuki reaction

Uses

Effective ligand in the Pd-catalyzed arylation of ester enolates

Uses

2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl can act as ligand used in the palladium-catalyzed Suzuki coupling and amination of unactivated aryl chlorides.

Application

2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenylacts as a growth regulator by binding to Toll-like receptor 4 (TLR4), which is important in cytokine signaling. It also inhibits allyl carbonate production and cross coupling reactions between aryl chlorides and nitrogen atoms or amines. It has an inhibitory effect on depression, but this effect is not related to its inhibitory effect on bromodomains.

2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl Suppliers

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View Lastest Price from 2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl manufacturers

Shanghai UCHEM Inc.

Product: 2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl 213697-53-1
Price: US $39.00-422.00/g
Min. Order: 5g
Purity: 0.98
Supply Ability: 25kg
Release date: 2023-12-13

Shaanxi Dideu Medichem Co. Ltd

Product: 2-Dicyclohexylphosphino-2'-(N,N-diMethylaMino)biphenyl 213697-53-1
Price: US $1.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 tons
Release date: 2020-01-14

XINXIANG RUNYU MATERIAL CO., LTD.

Product: 2-(Dicyclohexylphosphino)-2'-(N,N-diMethylaMino)biphenyl 213697-53-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 0.98
Supply Ability: 500kg
Release date: 2021-12-02

213697-53-1, 2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenylRelated Search:

N,N-Dimethylbenzylamine Biphenyl 1,3-Bis(aminomethyl)benzene Dimethylamine 2-(Dicyclohexylphosphino)biphenyl Dimethylamine hydrochloride 3-Dimethylaminopropylamine Minocycline 2-(Dicyclohexylphosphino)-2'-methylbiphenyl 2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl DICYCLOHEXYLPHOSPHINE CYCLOHEXYLPHOSPHINE DIBUTYLPHENYLPHOSPHINE DI-N-PENTYLPHENYLPHOSPHINE Dicyclohexylphenylphosphine 2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl m-xylenediamine

DAVEPHOS

2-DICYCLOHEXYLPHOSPHINO-2'-(N,N-DIMETHY&

2-(DICYCLOHEXYLPHOSPHINO)-2'-(DIMETHYLAMINO)BIPHENYL

2-DICYCLOHEXYLPHOSPHINO-2'-(N,N-DIMETHYLAMINO)BIPHENYL

2-Dicyclohexylphosphino-2'-(N,

2-(Dicyclohexylphosphino)-2'-(N,N-dimethylamino)biphenyl,98%DavePhos

2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)-

[1,1''-BIPHENYL]-2-AMINE, 2''-(DICYCLOHEXYLPHOSPHINO)-N,N-DIMETHYL-

2-Dicgclohexylphosphino-2’-(N,N-dimethylamino)biphenyl

Davep

2-(N,N-Dimethylamino)-2-(dicyclohexylphosphino)biphenyl

2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl,97%

2-Dicyclohexylphosphino-2-(N,N-dimethylamino)biphenyl,98%

2-Dicyclohexylphosphino-2-(N,N-dimethylamino)biphenyl（Davephos）

2-Dicyclohexylphosphino-2-(N,N-dimethylamino)biph

2-[2-(dicyclohexylphosphanyl)phenyl]-N,N-diMethylaniline

Davephos (2-(Di-tert-butylphosphino)biphenyl)

98% DavePhos

2-DicyclohexylphosphiNA-2'-(N,N-diMethylaMiNA)biphenyl

2'-(dicyclohexylphosphino)-N,N-diMethyl-[1,1'-biphenyl]-2-aMine

2-(Dicyclohexylphosphanyl)-2'-(dimethylamino)biphenyl

2'-(Dicyclohexylphosphanyl)-N,N-dimethylbiphenyl-2-amine, Dicyclohexyl[2'-(dimethylamino)biphenyl-2-yl]phosphine

N-[2'-(dicyclohexylphosphino)-1,1'-biphenyl-2-yl]-N,N-diMethylaMine

DavePhos 97%

2-(N,N-Dimethylamino)-2-(dicyclohexylphosphino)biphenyl, DavePhos

2-(Dicyclohexylphosphino)-2'-(N,N-dimethylamino))-1,1'-biphenyl, 98%

2-Dimethylamino-2'-dicyclohexylphosphinobiphenyl

2-(Dicyclohexylphosphino)-2'-(N,N-dimethylamino))-1,1'-biphenyl, 98% DavePhos

2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)bipheny

2-(Dicycloh

2-(Dicyclohexylphosphino)-2'-(N,N-dimethylamino)biphenyl,98%DavePh

phosphino-2'-(N,N-dimethyL

2-(Dicyclohexylphosphino)-2'-(dimethylamino)biphenyl&gt

2-(Dicyclohexylphosphino)-2'-(N,N-dimethylamino))-1,1'-biphenyl,98%

DavePhos 2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl

2-Dicyclohexylphosphino-2-(N,N-dimethyiamino)-1,1'-biphenyl

213697-53-1 2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl‘ 213697-53-1

(2-Dimethylamino-1,1'-biphenyl-2-yl)dicyclohexylphosphine

2-Dicyclohexyphenyl-2 '- (N, N-dimethylamine) - biphenyl

2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl

2'-(Dicyclohexylphosphino)-N,N-dimethyl-[1,1'-biphenyl]-2-amine

(2-Dimethylamino-1,1'-biphenyl-2-yl)dicyclohexylphosphine

2'-(dicyclohexylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine

2-(Dicyclohexylphosphino)-2'-(N,N-dimethylamino)biphenyl,DavePhos

213697-53-1

CH32NC6H4C6H4PC6H112

C26H36NP

Catalysis and Inorganic Chemistry

Buchwald Ligands

Phosphorus Compounds

Phosphine Ligands

Buchwald Ligands&Precatalysts

Achiral Phosphine

Aryl Phosphine

Buchwald Ligands Series

Phosphines

Biphenyl & Diphenyl ether

Phosphine Ligands