ChemicalBook > CAS DataBase List > 2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl
2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl
Reaction- Product Name
- 2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl
- CAS No.
- 213697-53-1
- Chemical Name
- 2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl
- Synonyms
- DAVEPHOS;2-(N,N-Dimethylamino)-2-(dicyclohexylphosphino)biphenyl;N-[2'-(dicyclohexylphosphino)-1,1'-biphenyl-2-yl]-N,N-diMethylaMine;Davep;2-(Dicycloh;98% DavePhos;DavePhos 97%;phosphino-2'-(N,N-dimethyL;2-Dicyclohexylphosphino-2'-(N,;2-DICYCLOHEXYLPHOSPHINO-2'-(N,N-DIMETHY&
- CBNumber
- CB6344872
- Molecular Formula
- C26H36NP
- Formula Weight
- 393.54
- MOL File
- 213697-53-1.mol
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2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl Property
- Melting point:
- 121-124 °C(lit.)
- Boiling point:
- 539.6±43.0 °C(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 5.04±0.18(Predicted)
- form
- crystal
- color
- white
- Water Solubility
- Insoluble
- Sensitive
- Air Sensitive
- InChIKey
- ZEMZPXWZVTUONV-UHFFFAOYSA-N
- CAS DataBase Reference
- 213697-53-1(CAS DataBase Reference)
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Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-22
- Safety Statements
- 26-36/37/39
- WGK Germany
- 3
- TSCA
- No
- HazardClass
- AIR SENSITIVE
- HS Code
- 29310099
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 638021
- Product name
- DavePhos
- Purity
- 97%
- Packaging
- 1g
- Price
- $31.88
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- 638021
- Product name
- DavePhos
- Purity
- 97%
- Packaging
- 5g
- Price
- $137
- Updated
- 2024/03/01
TCI Chemical
- Product number
- D3389
- Product name
- 2-(Dicyclohexylphosphino)-2'-(dimethylamino)biphenyl
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $138
- Updated
- 2024/03/01
TCI Chemical
- Product number
- D3389
- Product name
- 2-(Dicyclohexylphosphino)-2'-(dimethylamino)biphenyl
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $415
- Updated
- 2024/03/01
Strem Chemicals
- Product number
- 15-1145
- Product name
- 2-(Dicyclohexylphosphino)-2'-(N,N-dimethylamino))-1,1'-biphenyl, 98% DavePhos
- Packaging
- 500mg
- Price
- $38
- Updated
- 2024/03/01
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2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl Chemical Properties,Usage,Production
Reaction
- Ligand used in the Pd-catalyzed Suzuki coupling and animation of unactivated aryl chlorides. The reactions generally occur at room temperature and give high yields of product.
- Ligand used in Pd-catalyzed C-N bond formation. A general synthesis of N6-aryl-2'deoxyadenosine analogues.
- Ligand used in Pd-catalyzed N-arylation of indoles.
- Ligand used in Pd-catalyzed synthesis of aryl-tert-butyl ethers.
- Effective ligand in the Pd-catalyzed arylation of ester enolates.
- Ligand employed in arylation of ketone enolates using ortho-halo nitrobenezenes.
- Ligand employed in the amination of aryl nonaflates using Pd catalysts.
- Ligand used for cascade alkenyl amination/Heck reaction for the synthesis of indoles.
- Ligand used in Pd-catalyzed Kumada-Corriu cross coupling at low temperatures.
- Ligand used in Rh-catalyzed intramolecular hydroamination of unactivated terminal and internal alkenes with primary and secondary amines.
- Ligand used in Au-catalyzed cycloisomerization of allenes.
Description
2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl is a potent inhibitor of the enzyme bromodomain. Bromodomain has been implicated in cancer and other diseases. It binds to the bromodomain in a covalent manner, blocking the ATP site and inhibiting bromodomain function. This inhibition has been shown to be selective for bromodomains over other domains.
Chemical Properties
white to light yellow crystals or
Uses
suzuki reaction
Uses
Effective ligand in the Pd-catalyzed arylation of ester enolates
Uses
2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl can act as ligand used in the palladium-catalyzed Suzuki coupling and amination of unactivated aryl chlorides.
Application
2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenylacts as a growth regulator by binding to Toll-like receptor 4 (TLR4), which is important in cytokine signaling. It also inhibits allyl carbonate production and cross coupling reactions between aryl chlorides and nitrogen atoms or amines. It has an inhibitory effect on depression, but this effect is not related to its inhibitory effect on bromodomains.
2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl Preparation Products And Raw materials
Raw materials
Bromocyclohexane
Ammonium hydroxide
2-Bromochlorobenzene
2-Bromoaniline
Cyclohexane
Chlorocyclohexane
Diethylamine
5-Bromo-m-xylene
Phosphorus trichloride
4-Bromotoluene
1,2-Dibromoethane
Tetrahydrofuran
Diethyl ether
Ethyl acetate
Copper(I) chloride
Dichloromethane
2-Chloroaniline
Magnesium
Iodomethane
Dimethyl sulfate
Preparation Products
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View Lastest Price from 2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl manufacturers
Shanghai UCHEM Inc.
- Product
- 2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl 213697-53-1
- Price
- US $39.00-422.00/g
- Min. Order
- 5g
- Purity
- 0.98
- Supply Ability
- 25kg
- Release date
- 2023-12-13
XINXIANG RUNYU MATERIAL CO., LTD.
- Product
- 2-(Dicyclohexylphosphino)-2'-(N,N-diMethylaMino)biphenyl 213697-53-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 0.98
- Supply Ability
- 500kg
- Release date
- 2021-12-02
Honest Joy Holdings Limited
- Product
- 2-Dicyclohexylphosphino-2'-(n,n-dimethylamino)biphenyl 213697-53-1
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 97.3%
- Supply Ability
- 100 tons
- Release date
- 2022-01-26
213697-53-1, 2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenylRelated Search:
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