ChemicalBook > CAS DataBase List > Boc-Asp-OtBu

Boc-Asp-OtBu

Product Name: Boc-Asp-OtBu
CAS No.: 34582-32-6
Chemical Name: Boc-Asp-OtBu
Synonyms: BOC-L-ASP-OTBU;BOC-ASP-OTBU;BOC-ASP-OBUT;5-BOC-Asp-Ot Bu;Cbz-L-Asp Anhydride;BOC-ASPARTIC ACID-OTBU;Boc-Asp-OtBu USP/EP/BP;α-tert-Butyl-N-Boc-L-aspartate;(Tert-Butoxy)Carbonyl Asp-OtBu;1-tert-Butyl N-Boc-L-aspartate
CBNumber: CB6357634
Molecular Formula: C13H23NO6
Formula Weight: 289.32
MOL File: 34582-32-6.mol

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Boc-Asp-OtBu Property

Melting point:: 101-103?C
Boiling point:: 429.0±40.0 °C(Predicted)
Density: 1.139
storage temp.: Sealed in dry,2-8°C
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 4.13±0.19(Predicted)
form: Powder
color: White
optical activity: [α]/D -24.5±1.5°, c = 1 in methanol
BRN: 4191701
InChI: InChI=1S/C13H23NO6/c1-12(2,3)19-10(17)8(7-9(15)16)14-11(18)20-13(4,5)6/h8H,7H2,1-6H3,(H,14,18)(H,15,16)/t8-/m0/s1
InChIKey: RAUQRYTYJIYLTF-QMMMGPOBSA-N
SMILES: C(OC(C)(C)C)(=O)[C@H](CC(O)=O)NC(OC(C)(C)C)=O
CAS DataBase Reference: 34582-32-6(CAS DataBase Reference)

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Safety

WGK Germany: 3
HS Code: 2924 19 00

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H314Causes severe skin burns and eye damage

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P363Wash contaminated clothing before reuse.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.53032
Product name: Boc-Asp-OtBu
Purity: Novabiochem?
Packaging: 1g
Price: $77.1
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.53032
Product name: Boc-Asp-OtBu
Purity: Novabiochem?
Packaging: 5G
Price: $313
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.53032
Product name: Boc-Asp-OtBu
Purity: Novabiochem?
Packaging: 25g
Price: $1240
Updated: 2025/07/31

Sigma-Aldrich

Product number: 742325
Product name: Boc-Asp-OtBu
Purity: ≥97.0% (TLC)
Packaging: 5g
Price: $392
Updated: 2022/05/15

TCI Chemical

Product number: B4618
Product name: 1-tert-Butyl N-(tert-Butoxycarbonyl)-L-aspartate
Purity: >95.0%(HPLC)(T)
Packaging: 1g
Price: $46
Updated: 2025/07/31

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Boc-Asp-OtBu Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

An aspartic acid derivative, Boc-Asp-OtBu can be used in stereoselective synthesis

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

80963-08-2

34582-32-6

General procedure for the synthesis of N-tert-butoxycarbonyl-L-aspartic acid 1-tert-butyl ester from (S)-2-(BOC-amino) succinic acid (4-benzyl) ester (1-tert-butyl): (S)-2-(BOC-amino) succinic acid (4-benzyl) ester (1-tert-butyl) ester (1.04 g, 2.74 mmol) was reacted with 10% Pd/C (0.2 g) in a The mixture in anhydrous ethanol (20 mL) was placed under hydrogen atmosphere (50 psi) and the reaction was shaken for 3 hours. Upon completion of the reaction, the mixture was filtered and the filtrate was concentrated under vacuum to give a white crystalline solid N-tert-butyl N-tert-butoxycarbonyl-L-aspartate 1- tert-butyl ester (0.79 g, 100%). The product has a melting point of 97-99 °C (literature value 1: 97-98 °C; literature value 2: 98-100 °C); specific rotation [α]24D = -16.9 (c = 1.0, EtOH) and [α]23D = -23.6 (c = 1.5, MeOH) (literature 2: [α]22D = +19.6 (c = 1.0, CHCl3); literature 3: [α] 25D = -7.4 (c = 2.0, MeOH)).1H NMR (200 MHz, CDCl3) δ 10.33 (br s, 1H), 5.48 (d, 1H, J = 8.0 Hz), 4.45 (t, 1H, J = 4.0 Hz), 3.02 (dd, 1H, J1 = 17.0 Hz, J2 = 4.0 Hz), 2.81 ( dd, 1H, J1 = 11 Hz, J2 = 4.6 Hz), 1.45 (br s, 18H); 13C NMR (50 MHz, CDCl3) δ 175.8, 169.9, 155.7, 82.4, 80.2, 50.5, 36.8, 28.3, 27.9; High-resolution mass spectrometry (HRMS) calculations C13H23NaNO6(M + Na)+: 312.1423, measured value: 312.1420. references: 1. C. C. Yang, R. B. Merrifield. Journal of Organic Chemistry 1976, 41, 1032-1041; 2. Robert M. Adlington, Jack E. Baldwin, David Catterick, Gareth J. Pareth, J. Pritchard. J. Chem. Soc., Perkin Trans. 1, 1999, 855-866.

References

[1] Journal of the Chemical Society - Perkin Transactions 1, 1999, # 8, p. 855 - 866
[2] Tetrahedron, 2001, vol. 57, # 30, p. 6557 - 6566
[3] Patent: WO2011/20018, 2011, A1. Location in patent: Page/Page column 23
[4] Journal of the American Chemical Society, 2011, vol. 133, # 4, p. 1122 - 1133
[5] Journal of Organic Chemistry, 1993, vol. 58, # 9, p. 2369 - 2376

Boc-Asp-OtBu Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Boc-Asp-OtBu manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Boc-Asp-Otbu 34582-32-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%+
Supply Ability: 1T
Release date: 2023-12-25

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Boc-L-Asp-OtBu 34582-32-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T+
Release date: 2023-09-24

Career Henan Chemical Co

Product: Boc-Asp-OtBu 34582-32-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20kg
Release date: 2018-08-14

34582-32-6, Boc-Asp-OtBuRelated Search:

3-(BOC-AMINO)-1-PROPANOL 1-Methyl L-aspartate N-Methyl-L-aspartic acid BOC-GLYCINE METHYL ESTER Boc-Asp-OtBu Glycine tert butyl ester hydrochloride L-Aspartic acid Boc-Asp-OH N-Formyl-L-aspartic acid N-Boc-L-Homoserine Mono-tert-butyl succinate (S)-(-)-2-(Boc-Amino)-1,4-butanediol H-ASP-OTBU Boc-Asp(OtBu)-OH&#8226,BOC-ASP(OTBU)-OHCHA,BOC-ASP(OTBU)-OH DCHA BOC-ASP(OTBU)-OH BOC-ASP(OTBU)-OSU L-Aspartic acid 4-tert-butyl ester L-ASPARTIC ACID

N-[[(tert-Butyl)oxy]carbonyl]-L-aspartic acid 4-(tert-butyl) ester

(2S)-2-(tert-Butoxycarbonylamino)succinic acid 1-tert-butyl ester

N-(tert-Butoxycarbonyl)-L-aspartic acid 1-tert-butyl ester

N-tert-Butoxycarbonyl-L-aspartic acid 1-tert-butyl ester

5-BOC-Asp-Ot Bu

N-Boc-L-aspartic acid 1-tert-butyl ester, 95%

(3s)-4-[(2-Methylpropan-2-yl)oxy]-3-[(2-Methylpropan-2-yl)oxycarbonylaMino]-4-oxobutanoic Acid

L-Asparticacid, N-[(1,1-diMethylethoxy)carbonyl]-, 1-(1,1-diMethylethyl) ester

N-tert-Boc-L-aspartic Acid tert-Butyl Ester

N-(tert-Butoxycarbonyl)aspartic Acid α-tert-Butyl Ester

N-[(1,1-DiMethylethoxy)carbonyl]-L-aspartic Acid 1-(1,1-DiMethylethyl) Ester

N-α-t-Boc-L-aspartic Acid α-tert-Butyl Ester

α-tert-Butyl-N-Boc-L-aspartate

1-tert-Butyl N-(tert-Butoxycarbonyl)-L-aspartate

Boc-L-aspartic acid α-tert-butyl ester≥ 98% (HPLC)

BOC-ASP-OTBU

BOC-ASPARTIC ACID-OTBU

BOC-ASP-OBUT

BOC-L-ASP-OTBU

BOC-L-ASPARTIC ACID ALPHA-BUTYL ESTER

BOC-L-ASPARTIC ACID ALPHA-T-BUTYL ESTER

(3S)-4-(tert-butoxy)-3-{[(tert-butoxy)carbonyl]amino}-4-oxobutanoic acid

4-[(2-methylpropan-2-yl)oxy]-3-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]-4-oxobutanoic acid

(S)-4-(tert-Butoxy)-3-((tert-butoxycarbonyl)amino)-4-oxobutanoicacid

N-ALPHA-TERT-BUTYLOXYCARBONYL-L-ASPARTIC ACID-ALPHA-TERT-BUTYL ESTER

N-ALPHA-T-BUTYLOXYCARBONYL-L-ASPARTIC ACID-ALPHA-T-BUTYL ESTER

N-ALPHA-T-BUTOXYCARBONYL-L-ASPARTIC ACID ALPHA-T-BUTYL ESTER

N-ALPHA-T-BOC-L-ASPARTIC ACID ALPHA-T-BUTYL ESTER

N-tert-Butoxycarbonyl-L-aspartic acid tert-butyl ester

NALPHA-tert-Butoxycarbonyl-L-aspartic acid ALPHA-tert-butyl ester

Boc-L-Aspartic acid 1-tert-butyl ester

(S)-2-(tert-Butoxycarbonylamino)succinic acid 4-tert-butyl ester

N-(tert-Butoxycarbonyl)aspartic acid 4-tert-butyl ester

N-(tert-Butoxycarbonyl)-L-aspartic acid 4-tert-butyl ester

N-(tert-Butyloxycarbonyl)-L-aspartic acid 4-tert-butyl ester

(Tert-Butoxy)Carbonyl Asp-OtBu

Cbz-L-Asp Anhydride

N-tert-Butoxycarbonyl-L-aspartic acid 1-tert-butyl

N-tert-Butyloxycarbonyl-L-aspartic acid 1-tert-butyl ester

1-tert-Butyl N-(tert-Butoxycarbonyl)-L-aspartate &gt

N-Boc-L-asparticacid1-tert-butylester,95%

(3S)-4-[(2-methylpropan-2-yl)oxy]-3-[(2-methylpropan-2-yl)oxycarbonylamino]-4-oxobutanoicaci

1-tert-Butyl N-Boc-L-aspartate

Boc-Asp-OtBu USP/EP/BP

Boc-L-aspartic acid α-tert-butyl ester

1-(1,1-Dimethylethyl) hydrogen N-[(1,1-dimethylethoxy)carbonyl]-L-aspartate

Boc-L-aspartate tert-butyl ester

N-Boc-L-aspartic acid α-tert-butyl ester (Boc-Asp-OtBu)

N-Boc-L-aspartic acid 1-tert-butyl ester

1-(tert-Butyl) hydrogen N-N-BOC-L-aspartate

34582-32-6

C13H23NO6

Amino Acids & Derivatives

Chiral Reagents

Inhibitors

Amino Acid Derivatives

Aspartic acid [Asp, D]

Boc-Amino Acids and Derivative