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Boc-Asp-OtBu

Product Name
Boc-Asp-OtBu
CAS No.
34582-32-6
Chemical Name
Boc-Asp-OtBu
Synonyms
BOC-L-ASP-OTBU;BOC-ASP-OTBU;BOC-ASP-OBUT;5-BOC-Asp-Ot Bu;Cbz-L-Asp Anhydride;BOC-ASPARTIC ACID-OTBU;Boc-Asp-OtBu USP/EP/BP;α-tert-Butyl-N-Boc-L-aspartate;(Tert-Butoxy)Carbonyl Asp-OtBu;1-tert-Butyl N-Boc-L-aspartate
CBNumber
CB6357634
Molecular Formula
C13H23NO6
Formula Weight
289.32
MOL File
34582-32-6.mol
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Boc-Asp-OtBu Property

Melting point:
101-103?C
Boiling point:
429.0±40.0 °C(Predicted)
Density 
1.139
storage temp. 
Sealed in dry,2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
4.13±0.19(Predicted)
form 
Powder
color 
White
optical activity
[α]/D -24.5±1.5°, c = 1 in methanol
BRN 
4191701
InChI
InChI=1S/C13H23NO6/c1-12(2,3)19-10(17)8(7-9(15)16)14-11(18)20-13(4,5)6/h8H,7H2,1-6H3,(H,14,18)(H,15,16)/t8-/m0/s1
InChIKey
RAUQRYTYJIYLTF-QMMMGPOBSA-N
SMILES
C(OC(C)(C)C)(=O)[C@H](CC(O)=O)NC(OC(C)(C)C)=O
CAS DataBase Reference
34582-32-6(CAS DataBase Reference)
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Safety

WGK Germany 
3
HS Code 
2924 19 00
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H314Causes severe skin burns and eye damage

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P363Wash contaminated clothing before reuse.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.53032
Product name
Boc-Asp-OtBu
Purity
Novabiochem?
Packaging
1g
Price
$77.1
Updated
2025/07/31
Sigma-Aldrich
Product number
8.53032
Product name
Boc-Asp-OtBu
Purity
Novabiochem?
Packaging
5G
Price
$313
Updated
2025/07/31
Sigma-Aldrich
Product number
8.53032
Product name
Boc-Asp-OtBu
Purity
Novabiochem?
Packaging
25g
Price
$1240
Updated
2025/07/31
Sigma-Aldrich
Product number
742325
Product name
Boc-Asp-OtBu
Purity
≥97.0% (TLC)
Packaging
5g
Price
$392
Updated
2022/05/15
TCI Chemical
Product number
B4618
Product name
1-tert-Butyl N-(tert-Butoxycarbonyl)-L-aspartate
Purity
>95.0%(HPLC)(T)
Packaging
1g
Price
$46
Updated
2025/07/31
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Boc-Asp-OtBu Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

An aspartic acid derivative, Boc-Asp-OtBu can be used in stereoselective synthesis

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

80963-08-2

34582-32-6

General procedure for the synthesis of N-tert-butoxycarbonyl-L-aspartic acid 1-tert-butyl ester from (S)-2-(BOC-amino) succinic acid (4-benzyl) ester (1-tert-butyl): (S)-2-(BOC-amino) succinic acid (4-benzyl) ester (1-tert-butyl) ester (1.04 g, 2.74 mmol) was reacted with 10% Pd/C (0.2 g) in a The mixture in anhydrous ethanol (20 mL) was placed under hydrogen atmosphere (50 psi) and the reaction was shaken for 3 hours. Upon completion of the reaction, the mixture was filtered and the filtrate was concentrated under vacuum to give a white crystalline solid N-tert-butyl N-tert-butoxycarbonyl-L-aspartate 1- tert-butyl ester (0.79 g, 100%). The product has a melting point of 97-99 °C (literature value 1: 97-98 °C; literature value 2: 98-100 °C); specific rotation [α]24D = -16.9 (c = 1.0, EtOH) and [α]23D = -23.6 (c = 1.5, MeOH) (literature 2: [α]22D = +19.6 (c = 1.0, CHCl3); literature 3: [α] 25D = -7.4 (c = 2.0, MeOH)).1H NMR (200 MHz, CDCl3) δ 10.33 (br s, 1H), 5.48 (d, 1H, J = 8.0 Hz), 4.45 (t, 1H, J = 4.0 Hz), 3.02 (dd, 1H, J1 = 17.0 Hz, J2 = 4.0 Hz), 2.81 ( dd, 1H, J1 = 11 Hz, J2 = 4.6 Hz), 1.45 (br s, 18H); 13C NMR (50 MHz, CDCl3) δ 175.8, 169.9, 155.7, 82.4, 80.2, 50.5, 36.8, 28.3, 27.9; High-resolution mass spectrometry (HRMS) calculations C13H23NaNO6(M + Na)+: 312.1423, measured value: 312.1420. references: 1. C. C. Yang, R. B. Merrifield. Journal of Organic Chemistry 1976, 41, 1032-1041; 2. Robert M. Adlington, Jack E. Baldwin, David Catterick, Gareth J. Pareth, J. Pritchard. J. Chem. Soc., Perkin Trans. 1, 1999, 855-866.

References

[1] Journal of the Chemical Society - Perkin Transactions 1, 1999, # 8, p. 855 - 866
[2] Tetrahedron, 2001, vol. 57, # 30, p. 6557 - 6566
[3] Patent: WO2011/20018, 2011, A1. Location in patent: Page/Page column 23
[4] Journal of the American Chemical Society, 2011, vol. 133, # 4, p. 1122 - 1133
[5] Journal of Organic Chemistry, 1993, vol. 58, # 9, p. 2369 - 2376

Boc-Asp-OtBu Preparation Products And Raw materials

Raw materials

Preparation Products

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Boc-Asp-OtBu Suppliers

Americas 1 Canada 2 China 210 Europe 4 Germany 6 India 8 Japan 4 Switzerland 2 United Kingdom 9 United States 37 Global 283
Christof Senn Laboratories AG
Tel
--
Fax
--
Email
christof.senn@cslabs.ch
Country
Switzerland
ProdList
502
Advantage
58
Bachem AG
Tel
--
Fax
--
Email
sales.ch@bachem.com
Country
Switzerland
ProdList
438
Advantage
58
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View Lastest Price from Boc-Asp-OtBu manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd
Product
Boc-Asp-Otbu 34582-32-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%+
Supply Ability
1T
Release date
2023-12-25
Sichuan HongRi Pharma-Tech Co.,Ltd
Product
Boc-L-Asp-OtBu 34582-32-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T+
Release date
2023-09-24
Career Henan Chemical Co
Product
Boc-Asp-OtBu 34582-32-6
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20kg
Release date
2018-08-14

34582-32-6, Boc-Asp-OtBuRelated Search:

3-(BOC-AMINO)-1-PROPANOL 1-Methyl L-aspartate N-Methyl-L-aspartic acid BOC-GLYCINE METHYL ESTER Boc-Asp-OtBu Glycine tert butyl ester hydrochloride L-Aspartic acid Boc-Asp-OH N-Formyl-L-aspartic acid N-Boc-L-Homoserine Mono-tert-butyl succinate (S)-(-)-2-(Boc-Amino)-1,4-butanediol H-ASP-OTBU Boc-Asp(OtBu)-OH&#8226,BOC-ASP(OTBU)-OHCHA,BOC-ASP(OTBU)-OH DCHA BOC-ASP(OTBU)-OH BOC-ASP(OTBU)-OSU L-Aspartic acid 4-tert-butyl ester L-ASPARTIC ACID

  • N-[[(tert-Butyl)oxy]carbonyl]-L-aspartic acid 4-(tert-butyl) ester
  • (2S)-2-(tert-Butoxycarbonylamino)succinic acid 1-tert-butyl ester
  • N-(tert-Butoxycarbonyl)-L-aspartic acid 1-tert-butyl ester
  • N-tert-Butoxycarbonyl-L-aspartic acid 1-tert-butyl ester
  • 5-BOC-Asp-Ot Bu
  • N-Boc-L-aspartic acid 1-tert-butyl ester, 95%
  • (3s)-4-[(2-Methylpropan-2-yl)oxy]-3-[(2-Methylpropan-2-yl)oxycarbonylaMino]-4-oxobutanoic Acid
  • L-Asparticacid, N-[(1,1-diMethylethoxy)carbonyl]-, 1-(1,1-diMethylethyl) ester
  • N-tert-Boc-L-aspartic Acid tert-Butyl Ester
  • N-(tert-Butoxycarbonyl)aspartic Acid α-tert-Butyl Ester
  • N-[(1,1-DiMethylethoxy)carbonyl]-L-aspartic Acid 1-(1,1-DiMethylethyl) Ester
  • N-α-t-Boc-L-aspartic Acid α-tert-Butyl Ester
  • α-tert-Butyl-N-Boc-L-aspartate
  • 1-tert-Butyl N-(tert-Butoxycarbonyl)-L-aspartate
  • Boc-L-aspartic acid α-tert-butyl ester≥ 98% (HPLC)
  • BOC-ASP-OTBU
  • BOC-ASPARTIC ACID-OTBU
  • BOC-ASP-OBUT
  • BOC-L-ASP-OTBU
  • BOC-L-ASPARTIC ACID ALPHA-BUTYL ESTER
  • BOC-L-ASPARTIC ACID ALPHA-T-BUTYL ESTER
  • (3S)-4-(tert-butoxy)-3-{[(tert-butoxy)carbonyl]amino}-4-oxobutanoic acid
  • 4-[(2-methylpropan-2-yl)oxy]-3-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]-4-oxobutanoic acid
  • (S)-4-(tert-Butoxy)-3-((tert-butoxycarbonyl)amino)-4-oxobutanoicacid
  • N-ALPHA-TERT-BUTYLOXYCARBONYL-L-ASPARTIC ACID-ALPHA-TERT-BUTYL ESTER
  • N-ALPHA-T-BUTYLOXYCARBONYL-L-ASPARTIC ACID-ALPHA-T-BUTYL ESTER
  • N-ALPHA-T-BUTOXYCARBONYL-L-ASPARTIC ACID ALPHA-T-BUTYL ESTER
  • N-ALPHA-T-BOC-L-ASPARTIC ACID ALPHA-T-BUTYL ESTER
  • N-tert-Butoxycarbonyl-L-aspartic acid tert-butyl ester
  • NALPHA-tert-Butoxycarbonyl-L-aspartic acid ALPHA-tert-butyl ester
  • Boc-L-Aspartic acid 1-tert-butyl ester
  • (S)-2-(tert-Butoxycarbonylamino)succinic acid 4-tert-butyl ester
  • N-(tert-Butoxycarbonyl)aspartic acid 4-tert-butyl ester
  • N-(tert-Butoxycarbonyl)-L-aspartic acid 4-tert-butyl ester
  • N-(tert-Butyloxycarbonyl)-L-aspartic acid 4-tert-butyl ester
  • (Tert-Butoxy)Carbonyl Asp-OtBu
  • Cbz-L-Asp Anhydride
  • N-tert-Butoxycarbonyl-L-aspartic acid 1-tert-butyl
  • N-tert-Butyloxycarbonyl-L-aspartic acid 1-tert-butyl ester
  • 1-tert-Butyl N-(tert-Butoxycarbonyl)-L-aspartate &gt
  • N-Boc-L-asparticacid1-tert-butylester,95%
  • (3S)-4-[(2-methylpropan-2-yl)oxy]-3-[(2-methylpropan-2-yl)oxycarbonylamino]-4-oxobutanoicaci
  • 1-tert-Butyl N-Boc-L-aspartate
  • Boc-Asp-OtBu USP/EP/BP
  • Boc-L-aspartic acid α-tert-butyl ester
  • 1-(1,1-Dimethylethyl) hydrogen N-[(1,1-dimethylethoxy)carbonyl]-L-aspartate
  • Boc-L-aspartate tert-butyl ester
  • N-Boc-L-aspartic acid α-tert-butyl ester (Boc-Asp-OtBu)
  • N-Boc-L-aspartic acid 1-tert-butyl ester
  • 1-(tert-Butyl) hydrogen N-N-BOC-L-aspartate
  • 34582-32-6
  • C13H23NO6
  • Amino Acids & Derivatives
  • Chiral Reagents
  • Inhibitors
  • Amino Acid Derivatives
  • Aspartic acid [Asp, D]
  • Boc-Amino Acids and Derivative