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STREPTOLYSIN O

Product Name
STREPTOLYSIN O
CAS No.
98072-47-0
Chemical Name
STREPTOLYSIN O
Synonyms
STREPTOLYSIN O;Einecs 308-500-3;Streptococcus sp.;STREPTOLYSIN O REAGENT;STREPTOLYSIN O GAMMA-IRRADIATED;Hemolysins O, Streptococcus group A;STREPTOLYSIN O FROM STREPTOCOCCUS*PYOGEN ES;Native Streptococcus pyogenes Streptolysin O
CBNumber
CB6407012
Molecular Formula
NULL
Formula Weight
0
MOL File
Mol file
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STREPTOLYSIN O Property

storage temp. 
2-8°C
solubility 
H2O: soluble1mg/mL
form 
lyophilized powder
color 
white
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Safety

RIDADR 
UN 2811PIH 6.1 / PGI
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P262Do not get in eyes, on skin, or on clothing.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S5265
Product name
Streptolysin O from Streptococcus pyogenes
Purity
lyophilized powder, Protein ~3?% by Lowry, 25,000-50,000?U/vial
Packaging
25000units
Price
$240
Updated
2024/03/01
Sigma-Aldrich
Product number
S0149
Product name
Streptolysin O from Streptococcus pyogenes
Purity
γ-irradiated
Packaging
25000units
Price
$282
Updated
2024/03/01
Sigma-Aldrich
Product number
SAE0089
Product name
Streptolysin O from Streptococcus pyogenes
Purity
≥1,000,000?units/mg protein, recombinant, lyophilized powder, expressed in E. coli
Packaging
100KU
Price
$206
Updated
2023/06/20
Usbiological
Product number
506381
Product name
Streptolysin O
Packaging
1mg
Price
$472
Updated
2021/12/16
Usbiological
Product number
506382
Product name
Streptolysin O
Packaging
1mg
Price
$472
Updated
2021/12/16
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STREPTOLYSIN O Chemical Properties,Usage,Production

Uses

Permeabilizes membranes to permit cellular uptake of large or charged molecules.

Uses

Used to create holes (reversible pores) in cholesterol-enriched plasma membranes of eukaryotic cells allowing selective permeabilization with molecules such as proteins (up to 100 kDa) and siRNAs.

General Description

Streptolysin O (SLO) is an immunogenic, oxygen-labile toxin, hemolytic exotoxin which is reversibly activated by dithiothreitol. [1] It is released into the extracellular medium along with other toxins, including streptolysin S, during the growth of most strains of group A and many strains of groups C and G Streptococci. [1,2] SLO and Streptolysin S differ from each other in that SLO is immunogenic and oxygen-labile while Streptolysin S is oxygen-stable, nonimmunogenic and only active when associated with a carrier protein.[3] The hemolytic activity of SLO is mediated by formation of multimeric nanopores in cholesterol containing lipid membranes.

SLO may be used for cell permeabilization or hemolysis. The susceptibility of hemolysis by SLO varies significantly for erythrocytes from different animal species.[1] Permeabilization of cells using SLO has been performed on multiple cell types and for various applications. For instance it has been used to introduce antisense oligonucleotides into cultured eukaryotic cells;[3] to investigate the effect of guanine nucleotide analogues on phosphatidylinositol metabolism and protein kinase C (PKC) activation in live human T lymphocytes;[4] to monitor cholesterol oxidation within a membrane lipid bilayer; [5] and to label proteins inside living cells using external fluorophores.[6]

Biochem/physiol Actions

This product is produced by recombinant expression in Escherichia coli and contains the complete native protein sequence of SLO (Uniport ID: P0DF96 aa 34-571) without any added purification tags and has calculated molecular weight of 60,144 Dalton. The material is lyophilized from a solution containing 20 mM Sodium Hepes pH 7.5, 150 mM Sodium Chloride and 2 mM EDTA.

STREPTOLYSIN O Preparation Products And Raw materials

Raw materials

Preparation Products

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STREPTOLYSIN O Suppliers

China 26 Switzerland 1 United States 7 Global 34
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-400-6206333 18521732826
Fax
021-50323701
Email
market@aladdin-e.com
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China
ProdList
25003
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65
Nanjing Dulai Biotechnology Co., Ltd.
Tel
025-84699383-8003 18013301590
Fax
025-84699383-8003
Email
njduly@126.com
Country
China
ProdList
971
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55
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4428
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55
Shanghai Macklin Biochemical Co.,Ltd.
Tel
15221275939 15221275939
Fax
021-50706099
Email
shenlinxing@macklin.cn
Country
China
ProdList
16166
Advantage
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Hubei Jusheng Technology Co.,Ltd
Tel
027-59599241 18871490274
Fax
027-59599241
Email
1400878000@qq.com
Country
China
ProdList
9958
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58
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
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80
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32080
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58
ANHUI WITOP BIOTECH CO., LTD
Tel
+8615255079626
Email
eric@witopchemical.com
Country
China
ProdList
23541
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58
DC Chemicals
Tel
021-58447131 13564518121
Email
sales@dcchemicals.com
Country
China
ProdList
9409
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58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
ProdList
29774
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58

98072-47-0, STREPTOLYSIN ORelated Search:

Cupric acetylacetonate Tosylmethyl isocyanide Ethyl isocyanoacetate SALCOMINE N-BUTYLISOCYANIDE Tris(2,4-pentanedionato)chroMiuM(III) 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE METHYL ISOCYANOACETATE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) Benzyl isocyanide TERT-BUTYL ISOCYANIDE DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) Ferric acetylacetonate 2,4-PENTANEDIONE, SILVER DERIVATIVE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III) PHENYLSELENOL Aluminum acetylacetonate COBALT(II) ACETYLACETONATE

  • STREPTOLYSIN O
  • STREPTOLYSIN O REAGENT
  • Hemolysins O, Streptococcus group A
  • STREPTOLYSIN O GAMMA-IRRADIATED
  • STREPTOLYSIN O FROM STREPTOCOCCUS*PYOGEN ES
  • Einecs 308-500-3
  • Native Streptococcus pyogenes Streptolysin O
  • Streptococcus sp.
  • 98072-47-0
  • Antibiotics N-S
  • Antibiotics
  • Antibiotics A to Z
  • Biochemicals and Reagents
  • BioChemical
  • Enzymatic Cell Lysis and Protoplast Preparation
  • Enzymes, Inhibitors, and Substrates
  • Mammalian
  • Antibiotics N-SSignal Transduction Research Tools
  • EnzymesApplication Index
  • Lysing Enzymes and Protoplast PreparationEnzymes, Inhibitors, and Substrates
  • Antibiotics
  • Antibiotics A to
  • Cell Dissociation and Cell Lysis
  • BacteriaSignal Transduction Research Tools
  • Cell Lysis Reagents
  • Cell Signaling and Neuroscience
  • Enzymatic Cell Lysis and Protoplast Preparation
  • EnzymesEnzymes, Inhibitors, and Substrates
  • Mammalian
  • Toxins and Venoms