ChemicalBook > CAS DataBase List > STREPTOLYSIN O

STREPTOLYSIN O

Product Name
STREPTOLYSIN O
CAS No.
98072-47-0
Chemical Name
STREPTOLYSIN O
Synonyms
STREPTOLYSIN O;Einecs 308-500-3;Streptococcus sp.;STREPTOLYSIN O REAGENT;STREPTOLYSIN O GAMMA-IRRADIATED;Hemolysins O, Streptococcus group A;STREPTOLYSIN O FROM STREPTOCOCCUS*PYOGEN ES;Native Streptococcus pyogenes Streptolysin O
CBNumber
CB6407012
Molecular Formula
NULL
Formula Weight
0
MOL File
Mol file
More
Less

STREPTOLYSIN O Property

storage temp. 
2-8°C
solubility 
H2O: soluble1mg/mL
form 
lyophilized powder
color 
white
More
Less

Safety

RIDADR 
UN 2811PIH 6.1 / PGI
WGK Germany 
3
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P262Do not get in eyes, on skin, or on clothing.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S5265
Product name
Streptolysin O from Streptococcus pyogenes
Purity
lyophilized powder, Protein ~3?% by Lowry, 25,000-50,000?U/vial
Packaging
25000units
Price
$240
Updated
2024/03/01
Sigma-Aldrich
Product number
S0149
Product name
Streptolysin O from Streptococcus pyogenes
Purity
γ-irradiated
Packaging
25000units
Price
$282
Updated
2024/03/01
Sigma-Aldrich
Product number
SAE0089
Product name
Streptolysin O from Streptococcus pyogenes
Purity
≥1,000,000?units/mg protein, recombinant, lyophilized powder, expressed in E. coli
Packaging
100KU
Price
$206
Updated
2023/06/20
Usbiological
Product number
506381
Product name
Streptolysin O
Packaging
1mg
Price
$472
Updated
2021/12/16
Usbiological
Product number
506382
Product name
Streptolysin O
Packaging
1mg
Price
$472
Updated
2021/12/16
More
Less

STREPTOLYSIN O Chemical Properties,Usage,Production

Uses

Permeabilizes membranes to permit cellular uptake of large or charged molecules.

Uses

Used to create holes (reversible pores) in cholesterol-enriched plasma membranes of eukaryotic cells allowing selective permeabilization with molecules such as proteins (up to 100 kDa) and siRNAs.

General Description

Streptolysin O (SLO) is an immunogenic, oxygen-labile toxin, hemolytic exotoxin which is reversibly activated by dithiothreitol. [1] It is released into the extracellular medium along with other toxins, including streptolysin S, during the growth of most strains of group A and many strains of groups C and G Streptococci. [1,2] SLO and Streptolysin S differ from each other in that SLO is immunogenic and oxygen-labile while Streptolysin S is oxygen-stable, nonimmunogenic and only active when associated with a carrier protein.[3] The hemolytic activity of SLO is mediated by formation of multimeric nanopores in cholesterol containing lipid membranes.

SLO may be used for cell permeabilization or hemolysis. The susceptibility of hemolysis by SLO varies significantly for erythrocytes from different animal species.[1] Permeabilization of cells using SLO has been performed on multiple cell types and for various applications. For instance it has been used to introduce antisense oligonucleotides into cultured eukaryotic cells;[3] to investigate the effect of guanine nucleotide analogues on phosphatidylinositol metabolism and protein kinase C (PKC) activation in live human T lymphocytes;[4] to monitor cholesterol oxidation within a membrane lipid bilayer; [5] and to label proteins inside living cells using external fluorophores.[6]

Biochem/physiol Actions

This product is produced by recombinant expression in Escherichia coli and contains the complete native protein sequence of SLO (Uniport ID: P0DF96 aa 34-571) without any added purification tags and has calculated molecular weight of 60,144 Dalton. The material is lyophilized from a solution containing 20 mM Sodium Hepes pH 7.5, 150 mM Sodium Chloride and 2 mM EDTA.

STREPTOLYSIN O Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

STREPTOLYSIN O Suppliers

China 26 Switzerland 1 United States 7 Global 34
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32080
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
Creative Enzymes
Tel
1-516-855-7709
Fax
1-631-938-8127
Email
info@creative-enzymes.com
Country
United States
ProdList
8748
Advantage
58
Creative Enzymes
Tel
--
Fax
--
Email
info@creative-enzymes.com
Country
United States
ProdList
6057
Advantage
58
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
Creative Enzymes
Tel
--
Fax
--
Email
contact@creative-enzymes.com
Country
United States
ProdList
47
Advantage
50

98072-47-0, STREPTOLYSIN ORelated Search:

Cupric acetylacetonate Tosylmethyl isocyanide Ethyl isocyanoacetate SALCOMINE N-BUTYLISOCYANIDE Tris(2,4-pentanedionato)chroMiuM(III) 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE METHYL ISOCYANOACETATE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) Benzyl isocyanide TERT-BUTYL ISOCYANIDE DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) Ferric acetylacetonate 2,4-PENTANEDIONE, SILVER DERIVATIVE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III) PHENYLSELENOL Aluminum acetylacetonate COBALT(II) ACETYLACETONATE

  • STREPTOLYSIN O
  • STREPTOLYSIN O REAGENT
  • Hemolysins O, Streptococcus group A
  • STREPTOLYSIN O GAMMA-IRRADIATED
  • STREPTOLYSIN O FROM STREPTOCOCCUS*PYOGEN ES
  • Einecs 308-500-3
  • Native Streptococcus pyogenes Streptolysin O
  • Streptococcus sp.
  • 98072-47-0
  • Antibiotics N-S
  • Antibiotics
  • Antibiotics A to Z
  • Biochemicals and Reagents
  • BioChemical
  • Enzymatic Cell Lysis and Protoplast Preparation
  • Enzymes, Inhibitors, and Substrates
  • Mammalian
  • Antibiotics N-SSignal Transduction Research Tools
  • EnzymesApplication Index
  • Lysing Enzymes and Protoplast PreparationEnzymes, Inhibitors, and Substrates
  • Antibiotics
  • Antibiotics A to
  • Cell Dissociation and Cell Lysis
  • BacteriaSignal Transduction Research Tools
  • Cell Lysis Reagents
  • Cell Signaling and Neuroscience
  • Enzymatic Cell Lysis and Protoplast Preparation
  • EnzymesEnzymes, Inhibitors, and Substrates
  • Mammalian
  • Toxins and Venoms