ChemicalBook > CAS DataBase List > 2-FLUORO-4-IODONICOTINIC ACID METHYL ESTER

2-FLUORO-4-IODONICOTINIC ACID METHYL ESTER

Uses

Product Name: 2-FLUORO-4-IODONICOTINIC ACID METHYL ESTER
CAS No.: 884494-84-2
Chemical Name: 2-FLUORO-4-IODONICOTINIC ACID METHYL ESTER
Synonyms: Methyl 2-Fluoro-4-iodonicotinate;2-FLUORO-4-IODONICOTINIC ACID METHYL ESTER;Methyl 2-Fluoro-4-iodopyridin-3-ylcarbanate;Methyl 2-fluoro-4-iodopyridine-3-carboxylate;2-Fluoro-4-iodo-3-pyridinecarboxylic acid methyl ester;3-PYRIDINECARBOXYLIC ACID, 2-FLUORO-4-IODO-,METHYL ESTER;Methyl 2-fluoro-4-iodopyridine-3-carboxylate, 2-Fluoro-4-iodo-3-(methoxycarbonyl)pyridine
CBNumber: CB6468022
Molecular Formula: C7H5FINO2
Formula Weight: 281.02
MOL File: 884494-84-2.mol

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2-FLUORO-4-IODONICOTINIC ACID METHYL ESTER Property

Boiling point:: 287℃
Density: 1.913
Flash point:: 127℃
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: -3.86±0.18(Predicted)
Appearance: White to off-white Solid

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: F598808
Product name: 2-Fluoro-4-iodonicotinicacidmethylester
Packaging: 250mg
Price: $75
Updated: 2021/12/16

TRC

Product number: F598808
Product name: 2-Fluoro-4-iodonicotinicacidmethylester
Packaging: 500mg
Price: $115
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: Y14228
Product name: Methyl2-fluoro-4-iodopyridine-3-carboxylate
Purity: 98%
Packaging: 5g
Price: $120
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H23-K-X2
Product name: Methyl 2-fluoro-4-iodonicotinate
Packaging: 250mg
Price: $48
Updated: 2021/12/16

Apolloscientific

Product number: PC49357
Product name: Methyl2-fluoro-4-iodonicotinate
Packaging: 1g
Price: $68
Updated: 2021/12/16

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2-FLUORO-4-IODONICOTINIC ACID METHYL ESTER Chemical Properties,Usage,Production

Uses

2-Fluoro-4-iodonicotinic acid methyl ester can be used as a pharmaceutical synthesis intermediate.

Synthesis

884494-51-3

18107-18-1

884494-84-2

GENERAL STEPS: 2-Fluoro-4-iodonicotinic acid (5.13 g) was dissolved in a solvent mixture of ether (25 mL) and methanol (25 mL) under nitrogen protection. To this solution was slowly added a 10% hexane solution of trimethylsilylated diazomethane (32.9 g). The reaction mixture was stirred at room temperature for 3 hours. Upon completion of the reaction, the reaction solution was concentrated and the resulting residue was purified by silica gel column chromatography (eluent: hexane-ethyl acetate gradient) to afford methyl 2-fluoro-4-iodonicotinate (5.3 g). The structure of the product was confirmed by 1H NMR (300 MHz, DMSO-d6): δ 3.94 (3H, s), 7.98 (1H, dd, J = 5.3, 1.1 Hz), 8.07 (1H, dd, J = 5.3, 0.8 Hz).

References

[1] Patent: EP2921480, 2015, A1. Location in patent: Paragraph 0391; 0392
[2] Patent: WO2016/95204, 2016, A1. Location in patent: Page/Page column 62; 63

2-FLUORO-4-IODONICOTINIC ACID METHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-FLUORO-4-IODONICOTINIC ACID METHYL ESTER manufacturers

Career Henan Chemical Co

Product: 2-FLUORO-4-IODONICOTINIC ACID METHYL ESTER 884494-84-2
Price: US $1.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 200KG
Release date: 2018-12-19

884494-84-2, 2-FLUORO-4-IODONICOTINIC ACID METHYL ESTERRelated Search:

Iodine pentafluoride 2-FLUORONICOTINIC ACID METHYL ESTER 4-IODO-2-FLUORO-3-FORMYLPYRIDINE 4-IODONICOTINIC ACID 2-FLUORO-3-(HYDROXYMETHYL)-4-IODOPYRIDINE 2-Fluoronicotinic acid 2-FLUORO-4-IODO-3-PICOLINE 2-Fluoro-3-iodopyridine 2-FLUORO-3-FORMYLPYRIDINE 2-FLUORO-3-(HYDROXYMETHYL)PYRIDINE 2-FLUORO-4-IODONICOTINIC ACID 4-Iodo-3-methylpyridine 2-FLUORO-4-IODONICOTINIC ACID METHYL ESTER

2-FLUORO-4-IODONICOTINIC ACID METHYL ESTER

3-PYRIDINECARBOXYLIC ACID, 2-FLUORO-4-IODO-,METHYL ESTER

Methyl 2-fluoro-4-iodopyridine-3-carboxylate

Methyl 2-fluoro-4-iodopyridine-3-carboxylate, 2-Fluoro-4-iodo-3-(methoxycarbonyl)pyridine

Methyl 2-Fluoro-4-iodopyridin-3-ylcarbanate

2-Fluoro-4-iodo-3-pyridinecarboxylic acid methyl ester

Methyl 2-Fluoro-4-iodonicotinate

884494-84-2

C7H5FINO2

Boronic Acid

Heterocyclic Compounds