PROTAC 11

Product Name: PROTAC 11
CAS No.: 2093386-22-0
Chemical Name: PROTAC 11
Synonyms: PROTAC 11;PROTAC BET Degrader-1;N-[4-({4-[(3-cyclopropyl-1-ethyl-1H-pyrazol-5-yl)amino]-7-(3,5-dimethyl-1,2-oxazol-4-yl)-6-methoxy-9H-pyrimido[4,5-b]indol-2-yl}formamido)butyl]-2-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}acetamide;9H-Pyrimido[4,5-b]indole-2-carboxamide, 4-[(3-cyclopropyl-1-ethyl-1H-pyrazol-5-yl)amino]-7-(3,5-dimethyl-4-isoxazolyl)-N-[4-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]butyl]-6-methoxy-
CBNumber: CB64797096
Molecular Formula: C44H45N11O9
Formula Weight: 871.9
MOL File: 2093386-22-0.mol

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PROTAC 11 Property

Density: 1.59±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : ≥ 50 mg/mL (57.35 mM)
pka: 10.68±0.40(Predicted)
form: Solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0028483
Product name: PROTACBETDegrader-1
Purity: 98.84%
Packaging: 5mg
Price: $550
Updated: 2021/12/16

ChemScene

Product number: CS-0028483
Product name: PROTACBETDegrader-1
Purity: 98.84%
Packaging: 10mg
Price: $850
Updated: 2021/12/16

ChemScene

Product number: CS-0028483
Product name: PROTACBETDegrader-1
Purity: 98.84%
Packaging: 25mg
Price: $1850
Updated: 2021/12/16

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PROTAC 11 Chemical Properties,Usage,Production

Description

PROTAC BET Degrader-1 is a potent BET degrader based on PROTAC, decreasing BRD2, BRD3, and BRD4 protein levels at low concentration.

PROTAC BET Degrader-1 (Compound 9) is a potent BET degrader based on PROTAC, decreases the level of BRD2, BRD3, and BRD4 proteins in RS4;11 cells at 3-10 nM, and inhibits the growth of this cell line with an IC50 of 4.3 nM, and 45.5 nM for MOLM-13 cells[1].

References

[1]. Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481.

PROTAC 11 Preparation Products And Raw materials

Raw materials

Preparation Products

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PROTAC 11 Suppliers

China 13 United States 1 Global 14

Sichuan Wei Keqi Biological Technology Co., Ltd.

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2093386-22-0, PROTAC 11Related Search:

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PROTAC 11

PROTAC BET Degrader-1

9H-Pyrimido[4,5-b]indole-2-carboxamide, 4-[(3-cyclopropyl-1-ethyl-1H-pyrazol-5-yl)amino]-7-(3,5-dimethyl-4-isoxazolyl)-N-[4-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]butyl]-6-methoxy-

N-[4-({4-[(3-cyclopropyl-1-ethyl-1H-pyrazol-5-yl)amino]-7-(3,5-dimethyl-1,2-oxazol-4-yl)-6-methoxy-9H-pyrimido[4,5-b]indol-2-yl}formamido)butyl]-2-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}acetamide

2093386-22-0