3-Fluoro-4-methoxyacetophenone

Product Name: 3-Fluoro-4-methoxyacetophenone
CAS No.: 455-91-4
Chemical Name: 3-Fluoro-4-methoxyacetophenone
Synonyms: Deracoxib 3-FMAP;BUTTPARK 153\33-60;Deracoxib Impurity 1;3-FLURO-4-METHOXYACETOPHENONE;3-FLUORO-4-METHOXYACETOPHENONE;3'-FLUORO-4-METHOXYACETOPHENONE;3'-Fluoro-4'-methoxyacetophenone;3’-Fluoro-4’-methyoxyacetophenone;3'-Fluoro-4'-methoxyacetophenone98%;3'-Fluoro-4'-methoxyacetophenone>
CBNumber: CB6479734
Molecular Formula: C9H9FO2
Formula Weight: 168.16
MOL File: 455-91-4.mol

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3-Fluoro-4-methoxyacetophenone Property

Melting point:: 92-94 °C(lit.)
Boiling point:: 147-148 °C20 mm Hg(lit.)
Density: 1.1410 (estimate)
Flash point:: 147-148°C/20mm
storage temp.: Sealed in dry,Room Temperature
form: powder to crystal
color: White to Almost white
BRN: 2084062
CAS DataBase Reference: 455-91-4(CAS DataBase Reference)
NIST Chemistry Reference: Acetophenone, 3'-fluoro-4'-methoxy-(455-91-4)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39-36
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 2914790090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 361836
Product name: 3′-Fluoro-4′-methoxyacetophenone
Purity: 99%
Packaging: 5g
Price: $42.63
Updated: 2025/07/31

TCI Chemical

Product number: F0366
Product name: 3'-Fluoro-4'-methoxyacetophenone
Purity: >98.0%(GC)
Packaging: 5g
Price: $50
Updated: 2025/07/31

TCI Chemical

Product number: F0366
Product name: 3'-Fluoro-4'-methoxyacetophenone
Purity: >98.0%(GC)
Packaging: 25g
Price: $144
Updated: 2025/07/31

TRC

Product number: F593200
Product name: 3’-Fluoro-4’methoxyacetophenone
Packaging: 10g
Price: $120
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2617-3-12
Product name: 3'-Fluoro-4'-methoxyacetophenone
Purity: 98%
Packaging: 100g
Price: $130
Updated: 2021/12/16

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3-Fluoro-4-methoxyacetophenone Chemical Properties,Usage,Production

Uses

3’-Fluoro-4’methoxyacetophenone is used in the synthesis chalcones,

Preparation

Obtained by fluorination of 4-methoxyacetophenone with manganese (IV) tetrafluoride formed in situ using manganese (IV) dioxide and pyridinium polyhydrogenofluoride under very mild conditions.

General Description

3′-Fluoro-4′-methoxyacetophenone can be prepared by Friedel-Crafts reaction of o-fluoroanisole with acetic anhydride.

Synthesis

321-28-8

75-36-5

455-91-4

Under ice bath conditions, 6.38 g (48 mmol) of aluminum trichloride and 40 mL of methylene chloride were added to a 100 mL round bottom flask and stirred until dissolved. Subsequently, 4.68 g (60 mmol) of acetyl chloride was slowly added, keeping the reaction temperature at 5 to 10 °C. Stirring was continued at 5°C for 10 minutes, followed by the slow dropwise addition of 5.04 g (40 mmol) 2-fluoroanisole. After the dropwise addition was completed, the reaction mixture was stirred at 5°C for 1 hour. Upon completion of the reaction, the mixture was carefully poured into 100 mL of ice water to quench the reaction. The aqueous layer was extracted with dichloromethane (2 x 30 mL) and the organic phases were combined. The organic phase was washed sequentially with water (2 x 30 mL), dried over anhydrous magnesium sulfate, filtered and concentrated. The crude product was washed with petroleum ether and finally recrystallized with ethyl acetate to obtain the target product 3-fluoro-4-methoxyacetophenone in 92.4% yield.

References

[1] Patent: CN107686465, 2018, A. Location in patent: Paragraph 0041; 0053; 0054
[2] Patent: US6342510, 2002, B1. Location in patent: Page column 28
[3] Patent: US5098602, 1992, A
[4] Patent: WO2006/136829, 2006, A2. Location in patent: Page/Page column 123
[5] Journal of Organic Chemistry, 1953, vol. 18, p. 910,914

3-Fluoro-4-methoxyacetophenone Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Fluoro-4-methoxyacetophenone Suppliers

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View Lastest Price from 3-Fluoro-4-methoxyacetophenone manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 3-Fluoro-4-methoxyacetophenone 455-91-4
Price: US $30.00-10.00/KG
Min. Order: 50KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-24

Hebei Yiduo Import and Export Co., Ltd.

Product: 3-Fluoro-4-methoxyacetophenone 455-91-4
Price: US $100.00-80.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10000000
Release date: 2025-03-11

Hebei Yanxi Chemical Co., Ltd.

Product: 3-Fluoro-4-methoxyacetophenone 455-91-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20 tons
Release date: 2023-11-29

455-91-4, 3-Fluoro-4-methoxyacetophenoneRelated Search:

4'-Hydroxyacetophenone 4'-(Trifluoromethyl)acetophenone 3-Nitroacetophenone (Trifluoromethoxy)benzene 4-(Trifluoromethoxy)aniline Acetophenone 3',5'-Dimethoxyacetophenone 4-Nitroacetophenone L-PICEIN 3,4-Dimethoxyacetophenone 4'-Methylacetophenone 4'-Methoxyacetophenone 2-Bromoacetophenone 3-Methoxyacetophenone 2'-Methoxyacetophenone 4-Fluoroacetophenone 2-Fluoro-4-methoxyacetophenone Fluorine

BUTTPARK 153\33-60

3'-FLUORO-4-METHOXYACETOPHENONE

3-FLUORO-4-METHOXYACETOPHENONE

1-(3-FLUORO-4-METHOXY-PHENYL)-ETHANONE

1-(3-FLUORO-4-METHOXYPHENYL)-1-ETHANONE

3’-Fluoro-4’-methyoxyacetophenone

Ethanone, 1-(3-fluoro-4-methoxyphenyl)-

1-(3-fluoro-4-methoxyphenyl)ethan-1-one

3'-Fluoro-4'-methoxyacetophenone 98%

3'-Fluoro-4'-methoxyacetophenone98%

Deracoxib Impurity 1

Deracoxib 3-FMAP

3'-Fluoro-4'-methoxyacetophenone&gt

1-(3-Fluoro-4-methoxyphenyl)ethenone

3-FLURO-4-METHOXYACETOPHENONE

3'-Fluoro-4'-methoxyacetophenone

3′-Fluoro-4′-methoxyacetophenone, CAS 455-91-4

455-91-4

FC6H3OCH3COCH3

Carbonyl Compounds

C9

Building Blocks

Organic Building Blocks

Ketones

Fluorine series

Adehydes, Acetals & Ketones

Anisoles, Alkyloxy Compounds & Phenylacetates

Fluorine Compounds

C9

Carbonyl Compounds

Ketones

Aromatic Acetophenones & Derivatives (substituted)

ketone