SB 200646 HYDROCHLORIDE
- Product Name
- SB 200646 HYDROCHLORIDE
- CAS No.
- 143797-62-0
- Chemical Name
- SB 200646 HYDROCHLORIDE
- Synonyms
- SB-200646A;SB-200646A ，S0893;SB 200646A,SB200646A;SB 200646 hydrochloride, 5-HT2C/2B receptor antagonist;1-(1-Methyl-1H-indol-5-yl)-3-(pyridin-3-yl)urea hydrochloride
- CBNumber
- CB6497473
- Molecular Formula
- C15H14N4O.ClH
- Formula Weight
- 302.763
- MOL File
- 143797-62-0.mol
SB 200646 HYDROCHLORIDE Property
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMSO: ~26 mg/mL, soluble
- form
- solid
- color
- pale yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- S155033
- Product name
- SB200646Hydrochloride
- Packaging
- 50mg
- Price
- $865
- Updated
- 2021/12/16
- Product number
- CS-0024588
- Product name
- SB-200646A
- Purity
- 99.47%
- Packaging
- 5mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- 9177CN
- Product name
- SB200646hydrochloride
- Packaging
- 1mg
- Price
- $133
- Updated
- 2021/12/16
- Product number
- CS-0024588
- Product name
- SB-200646A
- Purity
- 99.47%
- Packaging
- 10mg
- Price
- $145
- Updated
- 2021/12/16
- Product number
- B5104
- Product name
- SB200646hydrochloride
- Packaging
- 10mg
- Price
- $228
- Updated
- 2021/12/16
SB 200646 HYDROCHLORIDE Chemical Properties,Usage,Production
Uses
SB 200646 Hydrochloride is a 5-HT2C antagonist.
in vivo
SB-200646A (20 mg/kg; intravenous injection; daily; for 21 days; male albino Sprague-Dawley rats) treatment significantly decreases the number of spontaneously active ventral tegmental area (VTA) dopaminergic neurons[1].
The i.v. administration of 4-16 mg/kg of SB-200646A significantly increases the firing rate and % events as bursts in spontaneously active VTA dopaminergic neurons and significantly increases the % events as burst in substantia nigra pars compacta (SNC) dopaminergic neurons[1].
| Animal Model: | Male albino Sprague-Dawley rats (200-225 g at the beginning of treatment and 300-350 g at the time of the experiment)[1] |
| Dosage: | 20 mg/kg |
| Administration: | Intravenous injection; daily; for 21 days |
| Result: | Significantly decreased the number of spontaneously active ventral tegmental area (VTA) dopaminergic neurons. |
IC 50
5-HT2B Receptor: 7.5 (pKi); 5-HT2C Receptor: 6.9 (pKi); 5-HT2A Receptor: 5.2 (pKi)
SB 200646 HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
SB 200646 HYDROCHLORIDE Suppliers
- Tel
- --
- Fax
- --
- customerservice@tocris.co.uk
- Country
- United Kingdom
- ProdList
- 5726
- Advantage
- 77