ChemicalBook > CAS DataBase List > SB 200646 HYDROCHLORIDE

SB 200646 HYDROCHLORIDE

Product Name
SB 200646 HYDROCHLORIDE
CAS No.
143797-62-0
Chemical Name
SB 200646 HYDROCHLORIDE
Synonyms
SB-200646A;SB-200646A ，S0893;SB 200646A,SB200646A;SB 200646 hydrochloride, 5-HT2C/2B receptor antagonist;1-(1-Methyl-1H-indol-5-yl)-3-(pyridin-3-yl)urea hydrochloride
CBNumber
CB6497473
Molecular Formula
C15H14N4O.ClH
Formula Weight
302.763
MOL File
143797-62-0.mol
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SB 200646 HYDROCHLORIDE Property

storage temp. 
Inert atmosphere,Room Temperature
solubility 
DMSO: ~26 mg/mL, soluble
form 
solid
color 
pale yellow
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TRC
Product number
S155033
Product name
SB200646Hydrochloride
Packaging
50mg
Price
$865
Updated
2021/12/16
ApexBio Technology
Product number
B5104
Product name
SB200646hydrochloride
Packaging
50mg
Price
$959
Updated
2021/12/16
ChemScene
Product number
CS-0024588
Product name
SB-200646A
Purity
99.47%
Packaging
100mg
Price
$760
Updated
2021/12/16
ChemScene
Product number
CS-0024588
Product name
SB-200646A
Purity
99.47%
Packaging
5mg
Price
$110
Updated
2021/12/16
ChemScene
Product number
CS-0024588
Product name
SB-200646A
Purity
99.47%
Packaging
50mg
Price
$480
Updated
2021/12/16
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SB 200646 HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

SB 200646 Hydrochloride is a 5-HT2C antagonist.

in vivo

SB-200646A (20 mg/kg; intravenous injection; daily; for 21 days; male albino Sprague-Dawley rats) treatment significantly decreases the number of spontaneously active ventral tegmental area (VTA) dopaminergic neurons[1].
The i.v. administration of 4-16 mg/kg of SB-200646A significantly increases the firing rate and % events as bursts in spontaneously active VTA dopaminergic neurons and significantly increases the % events as burst in substantia nigra pars compacta (SNC) dopaminergic neurons[1].

Animal Model:Male albino Sprague-Dawley rats (200-225 g at the beginning of treatment and 300-350 g at the time of the experiment)[1]
Dosage:20 mg/kg
Administration:Intravenous injection; daily; for 21 days
Result:Significantly decreased the number of spontaneously active ventral tegmental area (VTA) dopaminergic neurons.

IC 50

5-HT2B Receptor: 7.5 (pKi); 5-HT2C Receptor: 6.9 (pKi); 5-HT2A Receptor: 5.2 (pKi)

SB 200646 HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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SB 200646 HYDROCHLORIDE Suppliers

China 27 Switzerland 1 United Kingdom 1 United States 8 USA 1 Global 38
TargetMol Chemicals Inc.
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+1-781-999-5354; +17819995354
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marketing@targetmol.com
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United States
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TargetMol Chemicals Inc.
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support@targetmol.com
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Aladdin Scientific
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ApexBio Technology
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Abcam Limited
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MedChemExpress
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Riedel-de Haen AG
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143797-62-0, SB 200646 HYDROCHLORIDERelated Search:

SB-756050 MMP-2/MMP-9 INHIBITOR IV SB 200646 HYDROCHLORIDE m-tolyl 5-chloro-2-(ethylsulfonyl)pyrimidine-4-carboxylate SB 202190 SB 431542 SB 743921 5-[2-[4-[2-(Dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazol-4-yl]-2,3-dihydro-1H-inden-1-one oxime Pracinostat 6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline 4'-CHLORO-3-METHOXYCINNAMANILIDE SB-705498 SB 203580 SB 225002 SB242235 2-(5-Benzo[1,3]dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrate hydrochloride

  • SB-200646A
  • SB 200646A,SB200646A
  • SB 200646 hydrochloride, 5-HT2C/2B receptor antagonist
  • 1-(1-Methyl-1H-indol-5-yl)-3-(pyridin-3-yl)urea hydrochloride
  • SB-200646A ，S0893
  • 143797-62-0
  • C15H14N4OHCl05H2O