4-Cyanophenol

ChemicalBook > CAS DataBase List > 4-Cyanophenol

Product Name: 4-Cyanophenol
CAS No.: 767-00-0
Chemical Name: 4-Cyanophenol
Synonyms: 4-HYDROXYBENZONITRILE;4-HYDROXYBENZOHYDRAZIDE;P-CYANOPHENOL;PARA-CYANOPHENOL;Hydroxybenzonitrile;Benzonitrile, 4-hydroxy-;P-nitrile;AKOS 217-25;AKOS B004225;4-CYANOPHENOL
CBNumber: CB6681698
Molecular Formula: C7H5NO
Formula Weight: 119.12
MOL File: 767-00-0.mol

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4-Cyanophenol Property

Melting point:: 110-113 °C(lit.)
Boiling point:: 146 °C / 2mmHg
Density: 1.1871 (rough estimate)
refractive index: 1.5800 (estimate)
storage temp.: Inert atmosphere,Room Temperature
solubility: methanol: 0.1 g/mL, clear
form: Crystalline Powder
pka: 7.97(at 25℃)
color: Off-white to beige-gray
Water Solubility: slightly soluble
BRN: 386130
Stability:: Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference: 767-00-0(CAS DataBase Reference)
NIST Chemistry Reference: 4-Hydroxybenzoic acid nitrile(767-00-0)
EPA Substance Registry System: Benzonitrile, 4-hydroxy- (767-00-0)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-36/37/38
Safety Statements: 26-36-45-24/25
WGK Germany: 3
RTECS: DI4375000
Hazard Note: Irritant
TSCA: Yes
HS Code: 29269095

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C94009
Product name: 4-Cyanophenol
Purity: 95%
Packaging: 5g
Price: $36.4
Updated: 2024/03/01

TCI Chemical

Product number: C0842
Product name: 4-Hydroxybenzonitrile
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $23
Updated: 2024/03/01

TCI Chemical

Product number: C0842
Product name: 4-Hydroxybenzonitrile
Purity: >98.0%(GC)(T)
Packaging: 500g
Price: $220
Updated: 2024/03/01

Alfa Aesar

Product number: A15803
Product name: 4-Hydroxybenzonitrile, 98+%
Packaging: 50g
Price: $63.65
Updated: 2024/03/01

Alfa Aesar

Product number: A15803
Product name: 4-Hydroxybenzonitrile, 98+%
Packaging: 100g
Price: $105.65
Updated: 2024/03/01

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4-Cyanophenol Chemical Properties,Usage,Production

Chemical Properties

white crystalline powder or chips. 4-Hydroxybenzonitrile [767-00-0], 4-cyanophenol, 1-cyano-4-hydroxybenzene, Mr 119.2, forms colorless crystals of mp 113℃. 4-Hydroxybenzonitrile is produced by reaction of 4-bromophenol with copper (I) cyanide, by ammoxidation of p-cresol, by reaction of 4-chlorobenzonitrile with sodium methoxide, or by the catalyzed gas phase reaction of ethyl 4-hydroxybenzoate with ammonia. The nitrile is used for the production of the herbicides 3,5-dibromo- and 3,5-diiodo-4- hydroxybenzonitrile (Bromoxynil, Ioxynil, May & Baker).

Uses

Intermediates of Liquid Crystals

Uses

4-Cyanophenol is a precursor for the synthesis of a vasodilator, Levcromakalim. Bromination of 4-cyanophenol results in bromoxynil, a commercial herbicide. It can also be used as a component of deep eutectic solvent (DES) mixture.

Preparation

4-Cyanophenol is produced by reaction of 4-bromophenol with copper (I) cyanide, by ammoxidation of p-cresol, by reaction of 4-chlorobenzonitrile with sodium methoxide, or by the catalyzed gas phase reaction of ethyl 4-hydroxybenzoate with ammonia.

Definition

ChEBI: 4-cyanophenol is a member of phenols. It has a role as an EC 1.4.3.4 (monoamine oxidase) inhibitor. It is functionally related to a benzonitrile.

Synthesis Reference(s)

The Journal of Organic Chemistry, 39, p. 3343, 1974 DOI: 10.1021/jo00937a007

Purification Methods

Crystallise the phenol from pet ether, *benzene or water and keep it under vacuum over P2O5. [Bernasconi & Paschelis J Am Chem Soc 108 2969 1986.] [Beilstein 10 H 167, 10 IV 441.]

4-Cyanophenol Preparation Products And Raw materials

Raw materials

4-Hydroxybenzoic acid Phosphorus pentasulfide Urea Water 4-Hydroxybenzaldehyde Hydroxylamine hydrochloride Benzyl benzoate

Preparation Products

4-Hydroxybenzamidine hydrochloride 2-(4-CYANOPHENOXY)-2-METHYLPROPANOIC ACID Bromoxynil 2-(4-HYDROXYPHENYL)-5-PYRIMIDINOL CYANOPHOS

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View Lastest Price from 4-Cyanophenol manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: 4-Cyanophenol 767-00-0
Price: US $70.00-25.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-06-05

Hebei Weibang Biotechnology Co., Ltd

Product: 4-Cyanophenol 767-00-0
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 5tons
Release date: 2024-12-02

Hebei Chuanghai Biotechnology Co,.LTD

Product: 4-Cyanophenol P-Cyanophenol 767-00-0
Price: US $19.00/KG
Min. Order: 1KG
Purity: 99.%
Supply Ability: 50 ton
Release date: 2024-08-22

767-00-0, 4-CyanophenolRelated Search:

4'-Hydroxyacetophenone 4-Nitrobenzonitrile Glycolic acid 4-Methoxyphenol 4-Hydroxybenzamide Hydroxy silicone oil 4-Hydroxybenzaldehyde 4-Hydroxybenzoic acid Hydroxyapatite Benzonitrile Methylparaben 4-Hydrazinobenzoic acid hydrochloride 4-Hydrazinylbenzoic acid 4-METHOXY-1-NAPHTHONITRILE 2,3,4-TRIMETHOXYBENZONITRILE 2,4,6-Trimethoxybenzonitrile 4-Hydroxy-3-methoxybenzonitrile 2,4-Dimethoxybenzonitrile

p-hydroxy benzonitrile，p-cyano phenol

4-HYDROXYBENZONITRILE FOR SYNTHESIS

AKOS B004225

AKOS 217-25

4-CYANOPHENOL

4-HYDROXYBENZONITRILE

CYANOPHENOL(4-)

P-CYANOPHENOL

P-HYDROXYBENZONITRILE

p-Cyanolphenol

p-hydroxy-benzonitril

4-Hydroxybenzenecarbonitrile

P-nitrile

Right hydroxybenzonitrile

4-Cyanophenol, 99% 100GR

4-Cyanophenol, 99% 25GR

Febuxostat-21

p-Hydroxybenzonitrile 4-Cyanophenol

TIMTEC-BB SBB008054

P-Cyanophenol(4-HydroxyBenzonitrile)

4-Cyanophenol99%

4-Hydroxybenzonitrile, 98+%

4-Cyanophenol,98+%

4-HYDROXYBENZONITRILE (P-HYDROXYBENZONITRILE)

4-CYANOPHENOL(4-HYDROXYBENZONITRILE)

PARA-CYANOPHENOL

p-Hydroxybenzonitrile, 4-Hydroxybenzonitrile

Hydroxybenzonitrile

4-HYDROXYBENZONITRILE PESTANAL, 250 MG

4-HYDROXYBENZOHYDRAZIDE

The cyano phenol

4-Hydroxybenzo

4-Cyanolphenol

4-hydroxy-benzonitril

4-Cyanophenol, 97+%

Benzonitrile, 4-hydroxy-

Benzonitrile, p-hydroxy-

Benzonitrile,4-hydroxy-

4-Hydroxybenzonitrile &gt

Hydroxyphenonitrile

P-Hydroxybenzonitrite

4-Cyanophenol ISO 9001：2015 REACH

4-Cyanophenol (Febuxostat Impurity)

4-Cyanophenol P-Cyanophenol

4-Cyanophenol?New

767-00-0

676-00-0

767-00-1

CNC6H4OH

Nitrogen Compounds

Organic Building Blocks

Cyanides/Nitriles

Benzonitriles (Building Blocks for Liquid Crystals)

Building Blocks for Liquid Crystals

Building Blocks

C6 to C7

Aromatic Nitriles

Phenoles and thiophenoles