ChemicalBook > CAS DataBase List > 4-Cyanophenol

4-Cyanophenol

Product Name
4-Cyanophenol
CAS No.
767-00-0
Chemical Name
4-Cyanophenol
Synonyms
4-HYDROXYBENZONITRILE;4-HYDROXYBENZOHYDRAZIDE;P-CYANOPHENOL;PARA-CYANOPHENOL;Hydroxybenzonitrile;Benzonitrile, 4-hydroxy-;P-nitrile;AKOS 217-25;AKOS B004225;4-CYANOPHENOL
CBNumber
CB6681698
Molecular Formula
C7H5NO
Formula Weight
119.12
MOL File
767-00-0.mol
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4-Cyanophenol Property

Melting point:
110-113 °C(lit.)
Boiling point:
146 °C / 2mmHg
Density 
1.1871 (rough estimate)
refractive index 
1.5800 (estimate)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
methanol: 0.1 g/mL, clear
form 
Crystalline Powder
pka
7.97(at 25℃)
color 
Off-white to beige-gray
Water Solubility 
slightly soluble
BRN 
386130
Stability:
Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference
767-00-0(CAS DataBase Reference)
NIST Chemistry Reference
4-Hydroxybenzoic acid nitrile(767-00-0)
EPA Substance Registry System
Benzonitrile, 4-hydroxy- (767-00-0)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38
Safety Statements 
26-36-45-24/25
WGK Germany 
3
RTECS 
DI4375000
Hazard Note 
Irritant
TSCA 
Yes
HS Code 
29269095
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C94009
Product name
4-Cyanophenol
Purity
95%
Packaging
5g
Price
$36.4
Updated
2024/03/01
TCI Chemical
Product number
C0842
Product name
4-Hydroxybenzonitrile
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$23
Updated
2024/03/01
TCI Chemical
Product number
C0842
Product name
4-Hydroxybenzonitrile
Purity
>98.0%(GC)(T)
Packaging
500g
Price
$220
Updated
2024/03/01
Alfa Aesar
Product number
A15803
Product name
4-Hydroxybenzonitrile, 98+%
Packaging
50g
Price
$63.65
Updated
2024/03/01
Alfa Aesar
Product number
A15803
Product name
4-Hydroxybenzonitrile, 98+%
Packaging
100g
Price
$105.65
Updated
2024/03/01
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4-Cyanophenol Chemical Properties,Usage,Production

Chemical Properties

white crystalline powder or chips. 4-Hydroxybenzonitrile [767-00-0], 4-cyanophenol, 1-cyano-4-hydroxybenzene, Mr 119.2, forms colorless crystals of mp 113℃. 4-Hydroxybenzonitrile is produced by reaction of 4-bromophenol with copper (I) cyanide, by ammoxidation of p-cresol, by reaction of 4-chlorobenzonitrile with sodium methoxide, or by the catalyzed gas phase reaction of ethyl 4-hydroxybenzoate with ammonia. The nitrile is used for the production of the herbicides 3,5-dibromo- and 3,5-diiodo-4- hydroxybenzonitrile (Bromoxynil, Ioxynil, May & Baker).

Uses

Intermediates of Liquid Crystals

Uses

4-Cyanophenol is a precursor for the synthesis of a vasodilator, Levcromakalim. Bromination of 4-cyanophenol results in bromoxynil, a commercial herbicide. It can also be used as a component of deep eutectic solvent (DES) mixture.

Preparation

4-Cyanophenol is produced by reaction of 4-bromophenol with copper (I) cyanide, by ammoxidation of p-cresol, by reaction of 4-chlorobenzonitrile with sodium methoxide, or by the catalyzed gas phase reaction of ethyl 4-hydroxybenzoate with ammonia.

Definition

ChEBI: 4-cyanophenol is a member of phenols. It has a role as an EC 1.4.3.4 (monoamine oxidase) inhibitor. It is functionally related to a benzonitrile.

Synthesis Reference(s)

The Journal of Organic Chemistry, 39, p. 3343, 1974 DOI: 10.1021/jo00937a007

Purification Methods

Crystallise the phenol from pet ether, *benzene or water and keep it under vacuum over P2O5. [Bernasconi & Paschelis J Am Chem Soc 108 2969 1986.] [Beilstein 10 H 167, 10 IV 441.]

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4-Cyanophenol Suppliers

INTATRADE GmbH
Tel
+49 3493/605464
Fax
+49 3493/605470
Email
sales@intatrade.de
Country
Germany
ProdList
3572
Advantage
66
HPC Standards GmbH
Tel
--
Fax
--
Email
chulze@hpc-standards.com
Country
Germany
ProdList
2139
Advantage
58
KHBoddin GmbH
Tel
--
Fax
--
Email
info@khboddin.com
Country
Germany
ProdList
132
Advantage
58
Alfa Aesar, Thermo Fisher Scientific
Tel
--
Fax
--
Email
es@alfa.com
Country
Germany
ProdList
5123
Advantage
58
Alzchem AG
Tel
--
Fax
--
Email
info@alzchem.com
Country
Germany
ProdList
98
Advantage
58
ChemPur GmbH
Tel
--
Fax
--
Email
info@ChemPur.de
Country
Germany
ProdList
2737
Advantage
50
CHEMOS GmbH & Co. KG
Tel
--
Fax
--
Email
chemos@chemos.de
Country
Germany
ProdList
6727
Advantage
58
Dr. Ehrenstorfer GmbH
Tel
--
Fax
--
Email
info@analytical-standards.com
Country
Germany
ProdList
5545
Advantage
66
SYNTHON Chemicals GmbH & Co. KG
Tel
--
Fax
--
Email
synthon@synthon-chemicals.com
Country
Germany
ProdList
2000
Advantage
65
ABCR GmbH & CO. KG
Tel
--
Fax
--
Email
info@abcr.de
Country
Germany
ProdList
6831
Advantage
75
PARAGOS
Tel
--
Fax
--
Email
info@paragos.com
Country
Germany
ProdList
6371
Advantage
39
Service Chemical Inc.
Tel
--
Fax
--
Email
sales@chemos-group.com
Country
Germany
ProdList
6350
Advantage
71
SysKem Chemiehandel GmbH
Tel
--
Fax
--
Email
info@syskem.de
Country
Germany
ProdList
322
Advantage
38
Merck Schuchardt OHG
Tel
--
Fax
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Email
schuchardt-vertrieb@merck.de
Country
Germany
ProdList
5827
Advantage
74
AKos Consulting & Solutions GmbH
Tel
--
Fax
--
Email
akos@akosgmbh.de
Country
Germany
ProdList
6717
Advantage
72
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View Lastest Price from 4-Cyanophenol manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
4-Cyanophenol 767-00-0
Price
US $70.00-25.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-06-05
Hebei Weibang Biotechnology Co., Ltd
Product
4-Cyanophenol 767-00-0
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
5tons
Release date
2024-12-02
Hebei Chuanghai Biotechnology Co,.LTD
Product
4-Cyanophenol P-Cyanophenol 767-00-0
Price
US $19.00/KG
Min. Order
1KG
Purity
99.%
Supply Ability
50 ton
Release date
2024-08-22

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