HISPIDULIN

ChemicalBook > CAS DataBase List > HISPIDULIN

Product Name: HISPIDULIN
CAS No.: 1447-88-7
Chemical Name: HISPIDULIN
Synonyms: Dinatin;HISPIDULIN;Hispedulin;Methoxyapigenin;Hispidulin, >99%;6-Methoxyapigenin;Hispidulin(Dinatin);6-Methylscutellarein;SCUTELLAREIN 6-METHYL ETHER;4',5,7-Trihydroxy-6-methoxyflavone
CBNumber: CB6723941
Molecular Formula: C16H12O6
Formula Weight: 300.26
MOL File: 1447-88-7.mol

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HISPIDULIN Property

Melting point:: 291-292 °C
Boiling point:: 601.5±55.0 °C(Predicted)
Density: 1.512±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO: soluble20mg/mL, clear
form: powder
pka: 6.51±0.40(Predicted)
color: white to beige

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3
RTECS: DJ2996000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0582
Product name: Hispidulin
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $140
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0582
Product name: Hispidulin
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $543
Updated: 2024/03/01

Cayman Chemical

Product number: 26383
Product name: Hispidulin
Packaging: 5mg
Price: $86
Updated: 2024/03/01

Cayman Chemical

Product number: 26383
Product name: Hispidulin
Packaging: 25mg
Price: $305
Updated: 2024/03/01

Cayman Chemical

Product number: 26383
Product name: Hispidulin
Packaging: 1mg
Price: $32
Updated: 2024/03/01

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HISPIDULIN Chemical Properties,Usage,Production

Uses

Hispidulin has been used as a calibration standard:

in high-performance liquid chromatography (HPLC) for quantification of Clerodendrum petasites flavonoids
in liquid chromatography/electrospray ionization mass spectrometry (LC/ESI-MS) analysis
in reverse-phase high-performance liquid chromatography with a diode-array detector (HPLC-DAD) and high-performance thin-layer chromatography (HPTLC)

Definition

ChEBI: A monomethoxyflavone that is scutellarein methylated at position 6.

General Description

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Biological Activity

Partial positive allosteric modulator at the benzodiazepine receptor (IC 50 = 1.3 μ M for inhibition of flumazenil binding); natural sage flavone. Stimulates GABA-induced chloride currents in Xenopus oocytes expressing α 1 α 2-, α 3-, α 5- or α 6- β 2 γ 2S GABA A receptors. Brain penetrant; oral administration reduces seizures in a gerbil model of epilepsy. Also has antifungal, antiproliferative, antioxidant and antithrombotic properties.

Biochem/physiol Actions

Hispidulin is a bioactive flavonoid with a variety of effects including antiproliferative, antifungal, anti-inflammatory, antioxidative and antiepileptic activity. Like EGCG, hispidulin appears to activate AMPK and inhibit the PI3K/Akt/mTOR pathway. The antiepileptic activity may be due to additional activity as a benzodiazepine (BZD) receptor ligand.

HISPIDULIN Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from HISPIDULIN manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Hispidulin 1447-88-7
Price: US $0.00/mg
Min. Order: 20mg
Purity: ≥98%(HPLC)
Supply Ability: 100 g
Release date: 2020-08-13

Career Henan Chemical Co

Product: HISPIDULIN 1447-88-7
Price: US $6.60/KG
Min. Order: 500g
Purity: 98%
Supply Ability: 1kg, 50kg, 100kg
Release date: 2019-12-25

1447-88-7, HISPIDULINRelated Search:

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SCUTELLAREIN 6-METHYL ETHER

4',5,7-Trihydroxy-6-methoxyflavone

5,7-Dihydroxy-2-(4-hydroxyphenyl)-6-methoxy-4H-1-benzopyran-4-one

6-Methoxyapigenin

6-Methylscutellarein

Hispidulin(Dinatin)

Methoxyapigenin

Dinatin

Hispedulin

HISPIDULIN

Hispidulin, >99%

4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-(4-hydroxyphenyl)-6-methoxy-

5,7-dihydroxy-2-(4-hydroxyphenyl)-6-methoxychromen-4-one

1447-88-7

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