HISPIDULIN
- Product Name
- HISPIDULIN
- CAS No.
- 1447-88-7
- Chemical Name
- HISPIDULIN
- Synonyms
- Dinatin;HISPIDULIN;Hispedulin;Methoxyapigenin;Hispidulin, >99%;6-Methoxyapigenin;Hispidulin(Dinatin);6-Methylscutellarein;SCUTELLAREIN 6-METHYL ETHER;4',5,7-Trihydroxy-6-methoxyflavone
- CBNumber
- CB6723941
- Molecular Formula
- C16H12O6
- Formula Weight
- 300.26
- MOL File
- 1447-88-7.mol
HISPIDULIN Property
- Melting point:
- 291-292 °C
- Boiling point:
- 601.5±55.0 °C(Predicted)
- Density
- 1.512±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO: soluble20mg/mL, clear
- form
- powder
- pka
- 6.51±0.40(Predicted)
- color
- white to beige
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML0582
- Product name
- Hispidulin
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $140
- Updated
- 2024/03/01
- Product number
- SML0582
- Product name
- Hispidulin
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $543
- Updated
- 2024/03/01
- Product number
- 26383
- Product name
- Hispidulin
- Packaging
- 5mg
- Price
- $86
- Updated
- 2024/03/01
- Product number
- 26383
- Product name
- Hispidulin
- Packaging
- 25mg
- Price
- $305
- Updated
- 2024/03/01
- Product number
- 26383
- Product name
- Hispidulin
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
HISPIDULIN Chemical Properties,Usage,Production
Uses
Hispidulin has been used as a calibration standard:
- in high-performance liquid chromatography (HPLC) for quantification of Clerodendrum petasites flavonoids
- in liquid chromatography/electrospray ionization mass spectrometry (LC/ESI-MS) analysis
- in reverse-phase high-performance liquid chromatography with a diode-array detector (HPLC-DAD) and high-performance thin-layer chromatography (HPTLC)
Definition
ChEBI: A monomethoxyflavone that is scutellarein methylated at position 6.
General Description
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
Biological Activity
Partial positive allosteric modulator at the benzodiazepine receptor (IC 50 = 1.3 μ M for inhibition of flumazenil binding); natural sage flavone. Stimulates GABA-induced chloride currents in Xenopus oocytes expressing α 1 α 2-, α 3-, α 5- or α 6- β 2 γ 2S GABA A receptors. Brain penetrant; oral administration reduces seizures in a gerbil model of epilepsy. Also has antifungal, antiproliferative, antioxidant and antithrombotic properties.
Biochem/physiol Actions
Hispidulin is a bioactive flavonoid with a variety of effects including antiproliferative, antifungal, anti-inflammatory, antioxidative and antiepileptic activity. Like EGCG, hispidulin appears to activate AMPK and inhibit the PI3K/Akt/mTOR pathway. The antiepileptic activity may be due to additional activity as a benzodiazepine (BZD) receptor ligand.
HISPIDULIN Preparation Products And Raw materials
Raw materials
Preparation Products
HISPIDULIN Suppliers
- Tel
- +49-172-1024293
- Fax
- +49-(0)6422-938149
- pmc@transmit.de
- Country
- Germany
- ProdList
- 142
- Advantage
- 60
View Lastest Price from HISPIDULIN manufacturers
- Product
- Hispidulin 1447-88-7
- Price
- US $0.00/mg
- Min. Order
- 20mg
- Purity
- ≥98%(HPLC)
- Supply Ability
- 100 g
- Release date
- 2020-08-13
- Product
- HISPIDULIN 1447-88-7
- Price
- US $6.60/KG
- Min. Order
- 500g
- Purity
- 98%
- Supply Ability
- 1kg, 50kg, 100kg
- Release date
- 2019-12-25