4-Bromotoluene

Description References

Product Name: 4-Bromotoluene
CAS No.: 106-38-7
Chemical Name: 4-Bromotoluene
Synonyms: 1-BROMO-4-METHYLBENZENE;P-BROMOTOLUENE;PARA BROMO TOLUENE;1-Brom-4-methylbenzol;uene;ai328596;4-BromotoL;4-Bromtoluol;p-Tolybromide;p-bromo-toluen
CBNumber: CB6731117
Molecular Formula: C7H7Br
Formula Weight: 171.03
MOL File: 106-38-7.mol

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4-Bromotoluene Property

Melting point:: 26-29 °C(lit.)
Boiling point:: 184 °C(lit.)
Density: 1.39 g/mL at 25 °C(lit.)
refractive index: 1.549
Flash point:: 185 °F
storage temp.: Store below +30°C.
solubility: 0.11g/l insoluble
form: Crystalline Low Melting Mass
Specific Gravity: 1.390
color: White
Water Solubility: <0.1 g/100 mL at 24 ºC
Merck: 14,1439
BRN: 1903636
Dielectric constant: 5.5（58.0℃）
CAS DataBase Reference: 106-38-7(CAS DataBase Reference)
NIST Chemistry Reference: Benzene, 1-bromo-4-methyl-(106-38-7)
EPA Substance Registry System: p-Bromotoluene (106-38-7)

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Safety

Hazard Codes: Xn,N,T
Risk Statements: 22-38-51/53-36/37/38
Safety Statements: 28-61-37/39-26
RIDADR: UN 3077 9/PG 3
WGK Germany: 3
RTECS: XS7965600
TSCA: Yes
HazardClass: 9
PackingGroup: III
HS Code: 29036990
Hazardous Substances Data: 106-38-7(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H332Harmful if inhaled

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P273Avoid release to the environment.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: B82200
Product name: 4-Bromotoluene
Purity: 98%
Packaging: 5g
Price: $36.4
Updated: 2024/03/01

Sigma-Aldrich

Product number: B82200
Product name: 4-Bromotoluene
Purity: 98%
Packaging: 100g
Price: $57.2
Updated: 2024/03/01

TCI Chemical

Product number: B0661
Product name: 4-Bromotoluene
Purity: >99.0%(GC)
Packaging: 25g
Price: $39
Updated: 2024/03/01

TCI Chemical

Product number: B0661
Product name: 4-Bromotoluene
Purity: >99.0%(GC)
Packaging: 100g
Price: $89
Updated: 2024/03/01

Alfa Aesar

Product number: A15843
Product name: 4-Bromotoluene, 98%
Packaging: 25g
Price: $26.65
Updated: 2024/03/01

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4-Bromotoluene Chemical Properties,Usage,Production

Description

4-Bromotoluene is a p-substituted aryl bromide. As a toluene derivative, it is used as a solvent and starting material for organic synthesis and is found in paints, paint thinners, glues, and other products. 4-Bromotoluene was used in the synthesis of ketones by Cu/Pd-catalyzed decarboxylative cross-coupling reaction. It is also used in manufacturing pharmaceuticals (especially for antihypertensive like losartan, Irbesartan), pesticides and other organic compounds^1-3.

References

https://www.sigmaaldrich.com/catalog/search?term=4-Bromotoluene&interface=All&N=0&mode=match%20partialmax&lang=en&region=US&focus=product
https://bbzfrankie.wordpress.com/2013/11/21/application-of-4-bromotoluene/
https://toxnet.nlm.nih.gov/cgi-bin/sis/search/a?dbs+hsdb:@term+@DOCNO+6015

Chemical Properties

white crystalline low melting mass, soluble in ethanol, ether and benzene, insoluble in water. toxic, harmful if swallowed, irritating to eyes, respiratory system and skin. 4-bromotoluene is a raw material of organic synthesis, which can be used as the manufacture of p-bromobenzyl, p-bromodibromobenzyl and p-bromobenzaldehyde, etc.

Uses

4-Bromotoluene was used in the synthesis of ketones by Cu/Pd-catalyzed decarboxylative cross-coupling reaction. 4-Bromotoluene undergoes Heck reaction with styrene in the presence of in situ generated palladium complexes of phosphine-functionalized N-heterocyclic carbene ligands.

Preparation

4-Bromotoluene is prepared by diazotization and replacement of p-toluidine. First, add aqueous sulfuric acid solution to crushed p-toluidine while hot, cool to 5°C, and slowly add aqueous sodium nitrite solution until the starch potassium iodide test paper turns blue. Then add a small amount of urea to destroy the excess of sodium nitrite. Then add the synthesized cuprous bromide to hydrobromic acid, heat it to boiling, then slowly add the above diazo salt and distill it until no oil-like substance comes out. Wash, dry, filter, distill at atmospheric pressure and collect 183-185℃ fraction to obtain 4-Bromotoluene.

Synthesis Reference(s)

Organic Syntheses, Coll. Vol. 1, p. 136, 1941
Tetrahedron, 64, p. 4999, 2008 DOI: 10.1016/j.tet.2008.03.085

General Description

Crystals, clear pale yellow liquid.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

4-Bromotoluene is incompatible with strong oxidizing agents.

Fire Hazard

4-Bromotoluene is combustible.

Safety Profile

Moderately toxic by inhalation and intraperitoneal routes. When heated to decomposition it emits toxic vapors of Br-.

Purification Methods

Crystallise it from EtOH [Taylor & Stewart J Am Chem Soc 108 6977 1986]. [Beilstein 5 IV 827.]

4-Bromotoluene Preparation Products And Raw materials

Raw materials

PotassiuM iodide starch pa Sodium molybdate dihydrate Sodium bromide Copper shavings Cuprous bromide Copper(II) sulfate p-Toluidine

Preparation Products

(S)-(-)-2,2'-BIS(DI-P-TOLYLPHOSPHINO)-1,1'-BINAPHTHYL BIS(P-TOLYL)PHOSPHINE OXIDE 4-((N,N-DIMETHYLAMINO)METHYL)PHENYLBORONIC ACID PINACOL ESTER HYDROCHLORIDE 4-Bromobenzoic acid (S)-7,7'-Bis[di(p-methylphenyl)phosphino]-1,1'-spirobiindane ,97% TRI-P-TOLYLPHOSPHINE (R)-(+)-7,7'-BIS[DI(4-METHYLPHENYL)PHOSPHINO]-2,2',3,3'-TETRAHYDRO-1,1'-SPIROBIINDANE (4-PHENYLAMINOCARBONYLPHENYL)BORONIC ACID 2-(4-Methylphenyl)pyridine 2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl TERT-BUTYL 4-(4-FORMYLBENZYL)PIPERAZINE-1-CARBOXYLATE (R)-(+)-TolBINAP 4-Bromobenzyl bromide 4-Bromobenzaldehyde 4-(METHOXYCARBONYL)PHENYLBORONIC ACID 4-N-BUTYLTOLUENE 3-(4-METHYLPHENYL)BENZALDEHYDE

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4-Bromotoluene Suppliers

Americas 1 Belgium 2 Canada 3 China 286 Cyprus 1 Europe 4 Germany 8 India 71 Israel 3 Italy 1 Japan 8 Russia 1 Slovakia 1 South Korea 2 Switzerland 3 The Netherlands 1 Ukraine 2 United Kingdom 17 United States 49 Global 464

Tokyo Chemical Industry UK Ltd.

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Molekula Limited

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MOLEKULA Ltd.

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Fluorochem Ltd

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VWR International

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View Lastest Price from 4-Bromotoluene manufacturers

Hebei Mujin Biotechnology Co.,Ltd

Product: 4-Bromotoluene 106-38-7
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-08-14

Shanghai Joiny Pharmaceutical Co.,LTD

Product: 4-Bromotoluene 106-38-7
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 500KG
Release date: 2023-03-30

Hebei Weibang Biotechnology Co., Ltd

Product: 4-Bromotoluene 106-38-7
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-26

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