2-Fluoroaniline Property

Melting point:

-29 °C

Boiling point:

182-183 °C(lit.)

Density 

1.151 g/mL at 25 °C(lit.)

vapor pressure 

1 hPa (20 °C)

refractive index 

n20/D 1.544(lit.)

Flash point:

140 °F

storage temp. 

Store below +30°C.

solubility 

17g/l

form 

Liquid

pka

3.2(at 25℃)

color 

Clear colorless

Specific Gravity

1.151

Water Solubility 

17 g/L (20°C)

BRN 

1524219

CAS DataBase Reference

348-54-9(CAS DataBase Reference)

NIST Chemistry Reference

Benzenamine, 2-fluoro-(348-54-9)

EPA Substance Registry System

o-Fluoroaniline (348-54-9)

Safety

Hazard Codes 

Xn,T,Xi

Risk Statements 

22-37/38-41-36/38-33-23/24/25

Safety Statements 

26-39-37/39-45-36/37-28

RIDADR 

UN 2941 6.1/PG 3

WGK Germany 

2

RTECS 

BY1390000

Autoignition Temperature

600 °C

Hazard Note 

Toxic/Irritant

TSCA 

T

HazardClass 

6.1

PackingGroup 

III

HS Code 

29214210

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H226Flammable liquid and vapour

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

H373May cause damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P314Get medical advice/attention if you feel unwell.

2-Fluoroaniline Chemical Properties,Usage,Production

Chemical Properties

2-Fluoroaniline is a clear colorless to brown liquid, toxic, insoluble in water, soluble in ethanol and ether, its vapor and air can form an explosive mixture, which can cause combustion and explosion in case of fire and high heat. Reacts with oxidants. Decomposed by high heat to release toxic gases.

Uses

2-Fluoroaniline (cas# 348-54-9) is a useful reagent for the synthesis of insecticides.

Application

2-Fluoroaniline can be used to synthesize thermosensitive dye FH-102, which is a black thermosensitive dye with wide application and excellent performance. The dye can be used in the production of terminal output printing paper of electronic computer, EEG recording paper, telephone fax paper and transparent thermal film for oil field.

Definition

ChEBI: 2-fluoroaniline is a derivative of aniline in which the hydrogen at position 2 has been substituted by fluorine. It is used as a pharmaceutical intermediate It is a primary arylamine and a fluoroaniline.

Synthesis Reference(s)

Tetrahedron Letters, 25, p. 3415, 1984 DOI: 10.1016/S0040-4039(01)91034-2

General Description

Clear liquid with a mild sweet odor. Sinks in and mixes slowly with water.

Air & Water Reactions

Water soluble.

Reactivity Profile

2-Fluoroaniline is a base. Neutralizes acids to form salts plus water in an exothermic reaction. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.

Health Hazard

Inhalation or ingestion causes bluish tint to fingernails, lips and ears indicative of cyanosis; headache, drowsiness, and nausea, followed by unconsciousness. Liquid can be absorbed through skin and cause similar symptoms. Contact with eyes causes irritation.

Fire Hazard

Special Hazards of Combustion Products: Irritating and toxic hydrogen fluoride and oxides of nitrogen may form in fires.

Metabolic pathway

2-Fluoro and 3-fluoroanilines are preferentially hydroxylated at the para-position, and 4-fluoroaniline is both p- and o-hydroxylated to a significant extent by rat liver microsomes and is not accompanied with an NIH shift to give 4-hydroxyl-3-fluoroaniline.