ChemicalBook > CAS DataBase List > N-Boc-1-aminocyclobutanecarboxylic acid

N-Boc-1-aminocyclobutanecarboxylic acid

Product Name
N-Boc-1-aminocyclobutanecarboxylic acid
CAS No.
120728-10-1
Chemical Name
N-Boc-1-aminocyclobutanecarboxylic acid
Synonyms
BOC-ACBC-OH;BOC-AC4C-OH;Boc-cVal-OH;BOC-1, 1-ACCB;BOC-CYCLOVALINE;Boc-1-Aminocyclobutanecarboxylic acid;Boc-1-aminocyclobutane-1-carboxylicaci;1-(BOC-AMINO)CYCLOBUTANECARBOXYLIC ACID;N-BOC-1-AMINOCYCLOBUTANE CARBOXYLIC ACID;BOC-1-AMINOCYCLOBUTANE-1-CARBOXYLIC ACID
CBNumber
CB7110182
Molecular Formula
C10H17NO4
Formula Weight
215.25
MOL File
120728-10-1.mol
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N-Boc-1-aminocyclobutanecarboxylic acid Property

Melting point:
129-133 °C(lit.)
Boiling point:
362.1±21.0 °C(Predicted)
Density 
1.18±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
soluble in Methanol
pka
4.14±0.20(Predicted)
form 
Powder
color 
White to light brown
BRN 
7994003
InChI
InChI=1S/C10H17NO4/c1-9(2,3)15-8(14)11-10(7(12)13)5-4-6-10/h4-6H2,1-3H3,(H,11,14)(H,12,13)
InChIKey
ROVVUKFHORPDSM-UHFFFAOYSA-N
SMILES
C1(NC(OC(C)(C)C)=O)(C(O)=O)CCC1
CAS DataBase Reference
120728-10-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
36
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29242990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
630802
Product name
N-Boc-1-aminocyclobutane carboxylic acid
Purity
97%
Packaging
1g
Price
$98.9
Updated
2023/06/20
Sigma-Aldrich
Product number
630802
Product name
N-Boc-1-aminocyclobutane carboxylic acid
Purity
97%
Packaging
5g
Price
$419
Updated
2023/06/20
TCI Chemical
Product number
B6086
Product name
N-tert-Butoxycarbonyl-1-aminocyclobutanecarboxylic Acid
Packaging
1G
Price
$26
Updated
2024/03/01
TCI Chemical
Product number
B6086
Product name
N-tert-Butoxycarbonyl-1-aminocyclobutanecarboxylic Acid
Packaging
5G
Price
$79
Updated
2024/03/01
Alfa Aesar
Product number
H62888
Product name
1-(Boc-amino)cyclobutanecarboxylic acid, 97%
Packaging
5g
Price
$179
Updated
2021/12/16
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N-Boc-1-aminocyclobutanecarboxylic acid Chemical Properties,Usage,Production

Description

N-Boc-1-aminocyclobutanecarboxylic acid (1-((tert-Butoxycarbonyl)amino)cyclobutanecarboxylic acid) is an organic compound used in the preparation of intermediates for Boc-apalutamide. Apalutamide is a prescription drug used to treat prostate cancer.

Uses

Boc-1-aminocyclobutane-1-carboxylic Acid is used in the synthesis of dipeptidyl nitriles with cathepsin-inhibiting activities. It is also used to prepare alkyl-oxo-aryl amides as novel antagonists of TRPA1 receptor.

Synthesis

Under stirring, add 1-aminocyclobutylcarboxylic acid (500mg, 4.34mmol) to 10mL of 0.5M sodium hydroxide solution, and add 10mL of 1,4-dioxane and di-tert-butyl dicarbonate (1.42g, 6.51 mmol), react for 15 hours. Extract with diethyl ether (20 mL × 2), add hydrochloric acid dropwise until the pH of the aqueous phase is 4, and extract with ethyl acetate (30 mL × 3). The organic phases were then combined, washed with saturated sodium chloride solution (20mL×2), dried over anhydrous sodium sulfate, filtered, and the filtrate was concentrated under reduced pressure to obtain the product N-Boc-1-aminocyclobutanecarboxylic acid (750mg, white solid), yield:80.6%.

N-Boc-1-aminocyclobutanecarboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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N-Boc-1-aminocyclobutanecarboxylic acid Suppliers

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View Lastest Price from N-Boc-1-aminocyclobutanecarboxylic acid manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
N-Boc-1-aminocyclobutanecarboxylic acid 120728-10-1
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-30
Career Henan Chemical Co
Product
N-Boc-1-aminocyclobutanecarboxylic acid 120728-10-1
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
10KG
Release date
2019-08-05

120728-10-1, N-Boc-1-aminocyclobutanecarboxylic acidRelated Search:

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  • 1-TERT-BUTOXYCARBONYLAMINO-CYCLOBUTANECARBOXYLIC ACID
  • 1-(T-BUTYLOXYCARBONYL-AMINO)-CYCLOBUTYL-1-CARBOXYLIC ACID
  • BOC-AC4C-OH
  • BOC-ACBC-OH
  • BOC-CYCLOVALINE
  • BOC-1-AMINOCYCLOBUTANE-1-CARBOXYLIC ACID
  • BOC-1-AMINO-1-CYCLOBUTANECARBOXYLIC ACID
  • BOC-1, 1-ACCB
  • Boc-1-Aminocyclobutanecarboxylic acid
  • N-BOC-1-AMINOCYCLOBUTYL-1-CARBOXYLIC ACID
  • Boc-1-aminocyclobutanecarboxylic acid-OH
  • 1-(Boc-amino)cyclobutanecarboxylic acid, Boc-cyclovaline
  • Cyclobutanecarboxylic acid, 1-[[(1,1-dimethylethoxy)carbonyl]amino]-
  • 1-[(tert-Butoxycarbonyl)amino]cyclobutane-1-carboxylic acid
  • 1N-1-BOC-Aminocyclobutyl-1-carboxylic acid
  • 1-(tert-butoxycarbonylaMino)cyclobutanecarboxylic axid
  • 1-aMino-2-[(tert-butoxy)carbonyl]cyclobutane-1-carboxylic acid
  • 1-(tert-butoxycarbonyl)cyclobutanecarboxylic acid
  • 1-(tert-butoxycarbonylaMino)cyclobutanecarboxylic
  • 1-[(tert-Butoxycarbonyl)amino]cyclobutane-1-carboxylic acid, tert-Butyl (1-carboxycyclobut-1-yl)carbamate
  • 1-Aminocyclobutane-1-carboxylic acid, N-BOC protected 97%
  • Boc-1-aminocyclobutane-1-carboxylicaci
  • N-tert-Butoxycarbonyl-1-aminocyclobutanecarboxylic Acid
  • N-Boc-1-aminocyclobutanecarboxylic acid USP/EP/BP
  • 1-(t-Butoxycarbonyl)aminocyclobutanecarboxylic acid
  • 1-[(2-methylpropan-2-yl)oxycarbonylamino]cyclobutane-1-carboxylic acid
  • N-Boc-1-amino-1-cyclobutane carboxylic acid
  • N-Boc-amino-1-cyclobutanecarboxylic acid
  • Boc-cVal-OH
  • 120728-10-1
  • 20728-10-1
  • CH33CO2CNHC4H6CO2H
  • Alicyclic Amino Acids
  • Unnatural Amino Acid Derivatives
  • Peptide Synthesis
  • Specialty Synthesis
  • Peptide
  • pharmacetical
  • Amino Acids and Derivatives
  • LG
  • White solid