4-Nitrophenylhydrazine Property

Melting point:

156 °C (dec.)(lit.)

Boiling point:

276.04°C (rough estimate)

Density 

1.00

refractive index 

1.6910 (estimate)

storage temp. 

Explosives area

pka

3.81±0.20(Predicted)

color 

Orange-red leaflets or needles

Water Solubility 

soluble in hot water

Merck 

14,6624

BRN 

608107

CAS DataBase Reference

100-16-3(CAS DataBase Reference)

NIST Chemistry Reference

P-nitrophenyl hydrazine(100-16-3)

EPA Substance Registry System

Hydrazine, (4-nitrophenyl)- (100-16-3)

Safety

Hazard Codes 

F,Xn

Risk Statements 

5-11-22-36/37/38-43-21/22

Safety Statements 

16-26-36/37/39-37/39-36

RIDADR 

UN 3376 4.1/PG 1

WGK Germany 

3

RTECS 

MV8225000

F 

4.6

Hazard Note 

Flammable/Harmful

HazardClass 

4.1

PackingGroup 

I

HS Code 

29280000

Toxicity

mmo-sat 2 mmol/L AEMIDF 44,801,82

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H228Flammable solid

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P363Wash contaminated clothing before reuse.

P370+P378In case of fire: Use … for extinction.

P501Dispose of contents/container to..…

4-Nitrophenylhydrazine Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powde

Uses

Analytical reagent (aldehydes, ketones).

Uses

4-Nitrophenylhydrazine is a nitro substituted aryl hydrazine with potential anticancer activity. Irritant.

Definition

ChEBI: A member of the class of phenylhydrazines that is phenylhydrazine substituted at the 4-position by a nitro group.

General Description

4-Nitrophenylhydrazine is a orange-red leaflet or needles wetted with water. 4-Nitrophenylhydrazine will emit toxic oxides of nitrogen when heated to decomposition. 4-Nitrophenylhydrazine is slightly heavier than water and insoluble in water. 4-Nitrophenylhydrazine may be irritating to skin, eyes and mucous membranes. 4-Nitrophenylhydrazine may be toxic by ingestion. 4-Nitrophenylhydrazine may be explosive and sensitive to friction in the dry state. 4-Nitrophenylhydrazine is used as a reagent for ketones and aliphatic aldehydes.

Reactivity Profile

4-NITROPHENYLHYDRAZINE is a powerful explosive. 4-Nitrophenylhydrazine can SELF-IGNITE in the presence of contaminants. Auto-ignition temperature may vary for 4-nitrophenylhydrazine similar to that of hydrazine which has an autoignition of as low as 74oC in contact with iron rust. Dangerous fire hazard or severe explosion can occur when exposed to heat, flame or oxidizing agents. Severe explosion may also occur by chemical reaction with alkali metals; BaO; CaO; K; Na; NH3; Cl2; chromates; CuO; Cu++ salts; F2; H2O2; iron rust; metallic oxides; PbO2;Ni; Ni(ClO4)2; HNO3; N2O; O2; liquid O2; K2Cr2O7; Na2Cr2O7; tetryl; zinc diamide; Zn(C2H5)2. Dangerous; when heated to decomposition 4-Nitrophenylhydrazine emits highly toxic nitrogen compounds; may explode by heat or chemical reaction. (Sax and Lewis, 1987) under Hydrazine p. 538-539.

Health Hazard

Some are toxic and may be fatal if inhaled, swallowed or absorbed through skin. Contact may cause burns to skin and eyes. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may cause pollution.

Safety Profile

Poison by intraperitoneal route.Mutation data reported. When heated to decomposition itemits toxic fumes of NOx. See also NITROCOMPOUNDS OF AROMATIC HYDROCARBONS

Purification Methods

Crystallise the hydrazine from EtOH. The hydrochloride has m 212o(dec) (from EtOH, also m 202-203o dec). [Beilstein 15 III 331, 15 IV 317.]