ChemicalBook > CAS DataBase List > 2-Chloro-6-trifluoromethylnicotinic acid

2-Chloro-6-trifluoromethylnicotinic acid

Product Name: 2-Chloro-6-trifluoromethylnicotinic acid
CAS No.: 280566-45-2
Chemical Name: 2-Chloro-6-trifluoromethylnicotinic acid
Synonyms: 2-CHLORO-6-(TRIFLUOROMETHYL)NICOTINIC ACID;RARECHEM AL BO 2184;2-chloro-6-trifluoromethyl niacin;2-chloro-6-trifluoromethylnicotinic;2-Chloro-6-(trifluoromethyl)nicotinic Acid >2-Chloro-6-(trifluoromethyl)nicotinic acid ,97%;2-CHLORO-6-TRIFLUOROMETHYL NICOTINIC ACID,97+%(GC);2-chloro-6-(trifluoromethyl)pyridine-3-carboxylicaci;2-CHLORO-6-TRUFLUOROMETHYL-3-PYRIDINECARBOXYLIC ACID;2-CHLORO-6-TRIFLUOROMETHYL-3-PYRIDINECARBOXYLIC ACID
CBNumber: CB7150225
Molecular Formula: C7H3ClF3NO2
Formula Weight: 225.55
MOL File: 280566-45-2.mol

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2-Chloro-6-trifluoromethylnicotinic acid Property

Melting point:: 120 °C
Boiling point:: 271.3±40.0 °C(Predicted)
Density: 1.603±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: powder to crystal
pka: 1.42±0.28(Predicted)
color: White to Light yellow
InChI: InChI=1S/C7H3ClF3NO2/c8-5-3(6(13)14)1-2-4(12-5)7(9,10)11/h1-2H,(H,13,14)
InChIKey: DXRBTBMFFGEVCX-UHFFFAOYSA-N
SMILES: C1(Cl)=NC(C(F)(F)F)=CC=C1C(O)=O
CAS DataBase Reference: 280566-45-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-22
Safety Statements: 26-36/37/39
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3
Hazard Note: Irritant
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 708208
Product name: 2-Chloro-6-(trifluoromethyl)pyridine-3-carboxylic acid
Purity: 97%
Packaging: 250mg
Price: $52
Updated: 2023/01/07

TCI Chemical

Product number: C2425
Product name: 2-Chloro-6-(trifluoromethyl)nicotinic Acid
Purity: >98.0%(T)
Packaging: 1g
Price: $89
Updated: 2025/07/31

TRC

Product number: C432858
Product name: 2-Chloro-6-(trifluoromethyl)nicotinic Acid
Packaging: 1g
Price: $75
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC11252
Product name: 2-Chloro-6-trifluoromethylnicotinic acid
Packaging: 500mg
Price: $75
Updated: 2021/12/16

Apolloscientific

Product number: PC2223
Product name: 2-Chloro-6-(trifluoromethyl)nicotinic Acid
Packaging: 1g
Price: $37
Updated: 2021/12/16

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2-Chloro-6-trifluoromethylnicotinic acid Chemical Properties,Usage,Production

Chemical Properties

White to Light yellow powder to crystal

Uses

2-Chloro-6-trifluoromethylnicotinic acid is used as an intermediate in organic synthesis.

Synthesis

124-38-9

39890-95-4

280566-45-2

Lithium diisopropylammonium (LDA) (44.2 g, 1.5 eq.) was added slowly and dropwise to a stirred tetrahydrofuran (1.0 L) solution of 2-chloro-6-(trifluoromethyl)pyridine (50.0 g, 1.0 eq.) at -78 °C. The reaction temperature was maintained at -78°C and after 2 hours of reaction, carbon dioxide (500 g) was passed into the reaction mixture. The reaction mixture was gradually warmed to room temperature and stirring was continued for 10 minutes. The reaction progress was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction mixture was acidified to pH 2 with 1N hydrochloric acid and then extracted with ethyl acetate (2 x 500 mL). The organic layers were combined, washed sequentially with water (500 mL) and brine (500 mL), dried with anhydrous sodium sulfate, and concentrated under reduced pressure to obtain the crude product. The crude product was co-milled with petroleum ether to obtain pure 2-chloro-6-(trifluoromethyl)nicotinic acid (Int-15) (40.0 g, yield 64.6%).

References

[1] European Journal of Organic Chemistry, 2004, # 18, p. 3793 - 3798
[2] Patent: WO2013/64460, 2013, A1. Location in patent: Page/Page column 125; 126

2-Chloro-6-trifluoromethylnicotinic acid Preparation Products And Raw materials

Raw materials

(Trifluoromethyl)trimethylsilane Hexane Nitrogen N-Methyl-2-pyrrolidone Cuprous iodide Potassium fluoride Carbon dioxide Diisopropylamine 2-Dimethylaminoethanol Tetrahydrofuran Iodine n-Butyllithium 2-Chloropyridine

Preparation Products

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View Lastest Price from 2-Chloro-6-trifluoromethylnicotinic acid manufacturers

Dideu Industries Group Limited

Product: 2-Chloro-6-trifluoromethylnicotinic acid 280566-45-2
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-10-22

Career Henan Chemical Co

Product: 2-Chloro-6-trifluoromethylnicotinic acid 280566-45-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 96%
Supply Ability: 500kg
Release date: 2018-08-20

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280566-45-2

C7H4ClF3NO2

Pyridine

Carboxylic Acids

pharmacetical

Carboxylic Acids

Pyridines

Heterocycle