2-Chloro-6-trifluoromethylnicotinic acid
- Product Name
- 2-Chloro-6-trifluoromethylnicotinic acid
- CAS No.
- 280566-45-2
- Chemical Name
- 2-Chloro-6-trifluoromethylnicotinic acid
- Synonyms
- 2-CHLORO-6-(TRIFLUOROMETHYL)NICOTINIC ACID;RARECHEM AL BO 2184;2-chloro-6-trifluoromethyl niacin;2-chloro-6-trifluoromethylnicotinic;2-Chloro-6-(trifluoromethyl)nicotinic Acid >2-Chloro-6-(trifluoromethyl)nicotinic acid ,97%;2-CHLORO-6-TRIFLUOROMETHYL NICOTINIC ACID,97+%(GC);2-chloro-6-(trifluoromethyl)pyridine-3-carboxylicaci;2-CHLORO-6-TRUFLUOROMETHYL-3-PYRIDINECARBOXYLIC ACID;2-CHLORO-6-TRIFLUOROMETHYL-3-PYRIDINECARBOXYLIC ACID
- CBNumber
- CB7150225
- Molecular Formula
- C7H3ClF3NO2
- Formula Weight
- 225.55
- MOL File
- 280566-45-2.mol
2-Chloro-6-trifluoromethylnicotinic acid Property
- Melting point:
- 120 °C
- Boiling point:
- 271.3±40.0 °C(Predicted)
- Density
- 1.603±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- powder to crystal
- pka
- 1.42±0.28(Predicted)
- color
- White to Light yellow
- InChI
- InChI=1S/C7H3ClF3NO2/c8-5-3(6(13)14)1-2-4(12-5)7(9,10)11/h1-2H,(H,13,14)
- InChIKey
- DXRBTBMFFGEVCX-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC(C(F)(F)F)=CC=C1C(O)=O
- CAS DataBase Reference
- 280566-45-2(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-22
- Safety Statements
- 26-36/37/39
- RIDADR
- UN 2811 6.1 / PGIII
- WGK Germany
- 3
- Hazard Note
- Irritant
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 708208
- Product name
- 2-Chloro-6-(trifluoromethyl)pyridine-3-carboxylic acid
- Purity
- 97%
- Packaging
- 250mg
- Price
- $52
- Updated
- 2023/01/07
- Product number
- C2425
- Product name
- 2-Chloro-6-(trifluoromethyl)nicotinic Acid
- Purity
- >98.0%(T)
- Packaging
- 1g
- Price
- $89
- Updated
- 2025/07/31
- Product number
- C432858
- Product name
- 2-Chloro-6-(trifluoromethyl)nicotinic Acid
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 009102
- Product name
- 2-Chloro-6-trifluoromethylnicotinic acid
- Packaging
- 1g
- Price
- $29
- Updated
- 2021/12/16
- Product number
- 006875
- Product name
- 2-Chloro-6-(trifluoromethyl)nicotinic acid
- Packaging
- 1g
- Price
- $33
- Updated
- 2021/12/16
2-Chloro-6-trifluoromethylnicotinic acid Chemical Properties,Usage,Production
Chemical Properties
White to Light yellow powder to crystal
Uses
2-Chloro-6-trifluoromethylnicotinic acid is used as an intermediate in organic synthesis.
Synthesis
124-38-9
39890-95-4
280566-45-2
Lithium diisopropylammonium (LDA) (44.2 g, 1.5 eq.) was added slowly and dropwise to a stirred tetrahydrofuran (1.0 L) solution of 2-chloro-6-(trifluoromethyl)pyridine (50.0 g, 1.0 eq.) at -78 °C. The reaction temperature was maintained at -78°C and after 2 hours of reaction, carbon dioxide (500 g) was passed into the reaction mixture. The reaction mixture was gradually warmed to room temperature and stirring was continued for 10 minutes. The reaction progress was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction mixture was acidified to pH 2 with 1N hydrochloric acid and then extracted with ethyl acetate (2 x 500 mL). The organic layers were combined, washed sequentially with water (500 mL) and brine (500 mL), dried with anhydrous sodium sulfate, and concentrated under reduced pressure to obtain the crude product. The crude product was co-milled with petroleum ether to obtain pure 2-chloro-6-(trifluoromethyl)nicotinic acid (Int-15) (40.0 g, yield 64.6%).
References
[1] European Journal of Organic Chemistry, 2004, # 18, p. 3793 - 3798
[2] Patent: WO2013/64460, 2013, A1. Location in patent: Page/Page column 125; 126
2-Chloro-6-trifluoromethylnicotinic acid Preparation Products And Raw materials
Raw materials
Preparation Products
2-Chloro-6-trifluoromethylnicotinic acid Suppliers
- Tel
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- Fax
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- sales@riccichimica.com
- Country
- Italy
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- 2146
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View Lastest Price from 2-Chloro-6-trifluoromethylnicotinic acid manufacturers
- Product
- 2-Chloro-6-trifluoromethylnicotinic acid 280566-45-2
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-22
- Product
- 2-Chloro-6-trifluoromethylnicotinic acid 280566-45-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 96%
- Supply Ability
- 500kg
- Release date
- 2018-08-20