N-Boc-4-oxo-L-proline

Product Name: N-Boc-4-oxo-L-proline
CAS No.: 84348-37-8
Chemical Name: N-Boc-4-oxo-L-proline
Synonyms: Boc-4-oxo-L-Pro;BOC-L-PRO(4-OXO);N-Boc-4-OXO-Pro-OH;BOC-4-OXO-L-PROLINE;N-Boc-4-oxo-proline;N-Boc-4-oxo-L-prolin;Teneint-F(Tene-int-B);1-BOC-4-OXO-L-PROLINE;N-Boc-4-oxo-L-proline;N-T-BOC-4-OXO-L-PROLINE
CBNumber: CB7170519
Molecular Formula: C10H15NO5
Formula Weight: 229.23
MOL File: 84348-37-8.mol

More

Less

N-Boc-4-oxo-L-proline Property

Melting point:: 160 °C (dec.)
alpha: 1 º (c=1 in chloroform)
Boiling point:: 390.8±42.0 °C(Predicted)
Density: 1.304±0.06 g/cm3(Predicted)
vapor pressure: 0.001Pa at 25℃
storage temp.: Inert atmosphere,2-8°C
form: Solid:crystalline
pka: 3.85±0.20(Predicted)
color: White to Almost white
optical activity: [α]22/D +19.0 to +23.0°, c = 0.5 in acetone
Water Solubility: Insoluble in water.
InChI: InChI=1S/C10H15NO5/c1-10(2,3)16-9(15)11-5-6(12)4-7(11)8(13)14/h7H,4-5H2,1-3H3,(H,13,14)/t7-/m0/s1
InChIKey: CKYGSXRXTIKGAJ-ZETCQYMHSA-N
SMILES: N1(C(OC(C)(C)C)=O)CC(=O)C[C@H]1C(O)=O
LogP: 0.49
CAS DataBase Reference: 84348-37-8(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: Xn
Risk Statements: 22-36
Safety Statements: 26
WGK Germany: 3
HS Code: 29339900

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H301Toxic if swalloed

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P405Store locked up.

More

Less

N-Bromosuccinimide Price

TCI Chemical

Product number: B4141
Product name: N-(tert-Butoxycarbonyl)-4-oxo-L-proline
Purity: >98.0%(T)
Packaging: 1g
Price: $41
Updated: 2025/07/31

TCI Chemical

Product number: B4141
Product name: N-(tert-Butoxycarbonyl)-4-oxo-L-proline
Purity: >98.0%(T)
Packaging: 5g
Price: $125
Updated: 2025/07/31

TRC

Product number: B658940
Product name: N-Boc-4-oxo-L-proline
Packaging: 100g
Price: $715
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: AAA0001666
Product name: N-BOC-4-OXO-L-PROLINE
Purity: 95.00%
Packaging: 1G
Price: $730
Updated: 2021/12/16

ChemScene

Product number: CS-M1682
Product name: 1,2-Pyrrolidinedicarboxylicacid,4-oxo-,1-(1,1-dimethylethyl)ester,(2S)-
Purity: ≥98.0%
Packaging: 500g
Price: $1488
Updated: 2021/12/16

More

Less

N-Boc-4-oxo-L-proline Chemical Properties,Usage,Production

Chemical Properties

white to off-white solid

Uses

N-Boc-4-oxo-L-proline is used in practical Synthesis of Boc-Protected cis-4-Trifluoromethyl and cis-4-Difluoromethyl-l- prolines.

Definition

ChEBI: Boc-L-Pro(4-oxo) is a proline derivative.

Synthesis

13726-69-7

84348-37-8

General procedure for the synthesis of (S)-1-(tert-butoxycarbonyl)-4-oxopyrrolidine-2-carboxylic acid from Boc-L-hydroxyproline: trichloroisocyanuric acid (75.6 g) was added to a solution (1000 mL) of ethyl acetate of (4R)-1-(tert-butoxycarbonyl)-4-hydroxy-L-proline (Formula IV, prepared according to the method of Example 1; 100 g). The reaction system was cooled to 0°C to -5°C. An ethyl acetate solution of TEMPO (3.38 g, dissolved in 50 mL of ethyl acetate) was slowly added at -5°C to 10°C and the reaction mixture was stirred at the same temperature for 20 minutes. Subsequently, the reaction system was warmed up to 25 °C to 30 °C and kept at this temperature and stirred for 60 min. Upon completion of the reaction, the reaction was quenched with deionized water (200 mL) and stirring was continued at 25°C to 30°C for 60 minutes. The reaction mixture was filtered through a Hyflo? bed. The filtrate was washed with deionized water (2 x 200 mL) and partitioned. The organic layer was washed with aqueous sodium chloride (prepared from 40 g sodium hydroxide dissolved in 200 mL of deionized water). The organic layer was concentrated under reduced pressure at about 50°C to give a residue. The residue was dissolved in ethyl acetate (100 mL) and hexane (400 mL) was slowly added. The reaction mixture was stirred at 25 °C to 30 °C for 30 min and filtered, and the resulting solid was washed with a mixture of ethyl acetate (20 mL) and hexane (80 mL) and dried under reduced pressure at 40 °C to 45 °C to give 1-(tert-butoxycarbonyl)-4-oxo-L-proline. Yield: 95.9%.

References

[1] Patent: WO2015/19238, 2015, A1. Location in patent: Page/Page column 9
[2] Journal of the American Chemical Society, 2017, vol. 139, # 17, p. 6152 - 6159
[3] Organic Process Research and Development, 2015, vol. 19, # 1, p. 270 - 283
[4] Patent: WO2004/5249, 2004, A1. Location in patent: Page 30-31
[5] Tetrahedron Letters, 1993, vol. 34, # 46, p. 7489 - 7492

N-Boc-4-oxo-L-proline Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

N-Boc-4-oxo-L-proline Suppliers

Americas 1 Canada 1 China 276 Europe 3 Germany 1 India 7 Japan 1 Switzerland 1 United Kingdom 8 United States 29 Global 328

ChemPep, Inc.

Tel: +1 (888) 615-9178 / (561) 791-8787
Fax: +1 (561) 791-8728
Email: service@chempep.com
Country: United States
ProdList: 2138
Advantage: 57

AbaChemScene

Tel: 732-484-9848
Fax: 888-484-5008
Email: sales@chemscene.com
Country: United States
ProdList: 3982
Advantage: 60

BOC Sciences

Tel: 16314854226; +16314854226
Email: inquiry@bocsci.com
Country: United States
ProdList: 19654
Advantage: 58

Accela ChemBio Inc.

Tel: +1-858-6993322
Fax: (+1)-858-876-1948
Email: info@accelachem.com
Country: United States
ProdList: 21193
Advantage: 58

Alchem Pharmtech,Inc.

Tel: 8485655694
Email: sales@alchempharmtech.com
Country: United States
ProdList: 63687
Advantage: 58

Aladdin Scientific

Tel
Email: tp@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

United States Biological

Tel: --
Fax: --
Email: sales@advtechind.com
Country: United States
ProdList: 6075
Advantage: 58

Alfa Chemistry

Tel: --
Fax: --
Email: info@Alfa-Chemistry.com
Country: United States
ProdList: 6814
Advantage: 0

Alfa Aesar

Tel: --
Fax: --
Email: tech@alfa.com
Country: United States
ProdList: 6814
Advantage: 81

United States Biological

Tel: --
Fax: --
Email: chemicals@usbio.net
Country: United States
ProdList: 6214
Advantage: 80

Combi-Blocks Inc.

Tel: --
Fax: --
Email: sales@combi-blocks.com
Country: United States
ProdList: 6618
Advantage: 69

SynQuest Laboratories, Inc.

Tel: --
Fax: --
Email: info@synquestlabs.com
Country: United States
ProdList: 6871
Advantage: 62

Riedel-de Haen AG

Tel: --
Fax: --
Country: United States
ProdList: 6773
Advantage: 87

TCI America

Tel: --
Fax: --
Email: sales@tciamerica.com
Country: United States
ProdList: 6909
Advantage: 75

Frontier Scientific, Inc.

Tel: --
Fax: --
Email: sales@frontiersci.com
Country: United States
ProdList: 6222
Advantage: 86

Matrix Scientific

Tel: --
Fax: --
Email: sales@matrixscientific.com
Country: United States
ProdList: 6632
Advantage: 80

ChemContract Research Inc.

Tel: --
Fax: --
Country: United States
ProdList: 1526
Advantage: 38

RnD SciChem, LLC

Tel: --
Fax: --
Email: rndscichem@gmail.com
Country: United States
ProdList: 569
Advantage: 0

CNH Technologies, Inc.

Tel: --
Fax: --
Email: info@cnhtechnologies.com
Country: United States
ProdList: 353
Advantage: 42

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6962
Advantage: 56

Aagile Labs Division of Tyger Scientific

Tel: --
Fax: --
Email: tygersci@yahoo.com
Country: United States
ProdList: 6568
Advantage: 68

AlliChem, LLC

Tel: --
Fax: --
Email: sales@allichemllc.com
Country: United States
ProdList: 6516
Advantage: 60

Chem-Impex International, Inc.

Tel: --
Fax: --
Country: United States
ProdList: 6730
Advantage: 64

Waterstone Technology, LLC

Tel: --
Fax: --
Email: sales@waterstonetech.com
Country: United States
ProdList: 6786
Advantage: 30

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6718
Advantage: 47

APAC Pharmaceutical, LLC

Tel: --
Fax: --
Email: sales@apacpharma.com
Country: United States
ProdList: 6322
Advantage: 38

ChemPacific Corporation

Tel: --
Fax: --
Email: sales@chempacific.com
Country: United States
ProdList: 6891
Advantage: 51

Allichem LLC

Tel: --
Fax: --
Email: lib@umbi.umd.edu
Country: United States
ProdList: 749
Advantage: 30

Glycopep Chemicals, Inc.

Tel: --
Fax: --
Email: sale@glycopep.com
Country: United States
ProdList: 202
Advantage: 64

More

Less

View Lastest Price from N-Boc-4-oxo-L-proline manufacturers

Career Henan Chemical Co

Product: N-Boc-4-oxo-L-proline 84348-37-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2018-08-06

84348-37-8, N-Boc-4-oxo-L-prolineRelated Search:

D-Proline cis-4-Hydroxy-L-proline N-Methyl-2-pyrrolidone BOC-L-Proline L-Proline Polyvinylpyrrolidone N-Vinyl-2-pyrrolidone Pyrrolidine L-PROLINE-(4-3H(N)) 4-OXO-PROLINE N-Boc-3-pyrrolidinone Carbamic acid, (2-oxopropyl)-, 1,1-dimethylethyl ester (9CI) Methyl 1-Methyl-2-oxopyrrolidine-3-carboxylate N-Boc-4-oxo-L-Proline methyl ester BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER 1-(TERT-BUTOXYCARBONYL)-4-OXOPYRROLIDINE-2-CARBOXYLIC ACID N-Boc-5-aminolevulinic acid Norvaline, 4-oxo- (9CI)

<I>N</I>-Boc-4-oxo-<SC>L</SC>-proline

(Tert-Butoxy)Carbonyl 4-oxo-Pro-OH

Teneint-F(Tene-int-B)

(2S)-N-Boc-4-oxo-L-proline

Boc-4-oxo-L-Pro

(2S)-N-Boc-4-Oxo-proline

(2S)-4-Oxopyrrolidine-2-carboxylic acid, N-BOC protected 97%

(2S)-1-(tert-Butoxycarbonyl)-4-oxo-2-pyrrolidinecarboxylic acid

N-(tert-Butoxycarbonyl)-4-oxo-L-proline

(2S)-4-Oxopyrrolidine-2-carboxylic acid, N-BOC protected

(2S)-4-Oxopyrrolidine-2-carboxylicacid,N-BOCprotected97%

(S)-4-OXO-PYRROLIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER

N-TERT-BOC-4-OXO-L-PROLINE

N-TERT-BUTOXYCABONYL-4-OXO-L-PROLINE

N-T-BOC-4-OXO-L-PROLINE

BOC-L-PRO(4-OXO)

BOC-4-OXO-L-PROLINE

N-BOC-4-OXO-L-PROLINE, 97%

(S)-1-(tert-Butoxycarbonyl)-4-oxopyrrolidine-2-carboxylic acid

(S)-1-Boc-4-oxo-2-pyrrolidinecarboxylic acid

1-BOC-4-OXO-L-PROLINE

N-(tert-butyloxycarbonyl)-4-oxo-L-proline

4-oxo-, 1-(1,1-dimethylethyl) ester, (2S)-

(S)-N-Boc-4-oxopyrrolidine-2-carboxylic acid, Boc-L-Pro(4-oxo)

(2S)-1-(tert-Butoxycarbonyl)-4-oxopyrrolidine-2-carboxylic acid, 1-(tert-Butoxycarbonyl)-4-oxo-L-proline, 4-Oxo-L-proline, N-BOC protected

(2S)-1-[(tert-butoxy)carbonyl]-4-oxopyrrolidine-2-carboxylic acid

1,2-Pyrrolidinedicarboxylic acid, 4-oxo-, 1-(1,1-diMethylethyl) ester, (2S)-

N-Boc-4-OXO-Pro-OH

N-(tert-Butoxycarbonyl)-4-oxo-L-proline &gt

Boc-4-oxo-Pro-OH（non-animal）

(S)-1-(tert-Butoxycarbonyl)-4-oxo-2-pyrrolidinecarboxylic Acid

N-Boc-4-oxo-L-proline USP/EP/BP

Tert butoxycarbonyl-4-oxo-l-proline

(2S)-1-[(2-methylpropan-2-yl)oxycarbonyl]-4-oxopyrrolidine-2-carboxylic acid

(S)-1-(tert-Butoxycarbonyl)-4-oxopyrrolidine-2-carboxylic

(S)-1-(tert-Butoxycarbonyl)-4-oxopyrrolidine-2-carboxylic aci

1-(1,1-Dimethylethyl) (2S)-4-oxo-1,2-pyrrolidinedicarboxylate

1-(tert-Butyl) (2S)-4-oxo-1,2-pyrrolidinedicarboxylate

2',3'-Di-0-acetyl-5'-deoxy-5-fuluro-D-cytidine'

(S)-1-Boc-4-oxopyrrolidine-2-carboxylic acid

N-Boc-4-oxo-proline

N-Boc-4-oxo-L-prolin

(2S)-1-tert-butoxycarbonyl-4-oxo-pyrrolidine-2-carboxylic acid - [B25595]

N-Boc-4-oxo-L-proline

84348-37-8

88348-37-8

84384-37-8

C25H36N4O10

Pharmaceuticalintermediates

pharmacetical