3-Bromothiophene

Product Name: 3-Bromothiophene
CAS No.: 872-31-1
Chemical Name: 3-Bromothiophene
Synonyms: S0501;DK938;3-Bromthiophen;β-bromothiophene;3-bromo-thiophen;3-BroMothiofuran;3-Bromothiophene;b-Bromothiophene;3-THIENYL BROMIDE;BROMOTHIOPHENE(3-)
CBNumber: CB7196229
Molecular Formula: C4H3BrS
Formula Weight: 163.04
MOL File: 872-31-1.mol

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3-Bromothiophene Property

Melting point:: <-10°C
Boiling point:: 150 °C (lit.)
Density: 1.74 g/mL at 25 °C (lit.)
refractive index: n20/D 1.591(lit.)
Flash point:: 140 °F
storage temp.: Keep in dark place,Sealed in dry,2-8°C
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Liquid
Specific Gravity: 1.740
color: Clear colorless to slightly yellow
Water Solubility: IMMISCIBLE
Sensitive: Light Sensitive/Stench
BRN: 105338
CAS DataBase Reference: 872-31-1(CAS DataBase Reference)
NIST Chemistry Reference: Thiophene, 3-bromo-(872-31-1)
EPA Substance Registry System: 3-Bromothiophene (872-31-1)

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Safety

Hazard Codes: T,Xi,N,Xn
Risk Statements: 10-25-41-51/53-36/37/38-23/24/25-20/21/22-43-36/37
Safety Statements: 26-36/37/39-45-61-38-28A-16-24/25-23-36-36/37-24/35
RIDADR: UN 2929 6.1/PG 2
WGK Germany: 3
F: 8
Hazard Note: Irritant
TSCA: T
HazardClass: 6.1
PackingGroup: II
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H226Flammable liquid and vapour

H301Toxic if swalloed

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H335May cause respiratory irritation

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 106224
Product name: 3-Bromothiophene
Purity: 97%
Packaging: 5g
Price: $60.3
Updated: 2025/07/31

Sigma-Aldrich

Product number: 106224
Product name: 3-Bromothiophene
Purity: 97%
Packaging: 25g
Price: $97.6
Updated: 2025/07/31

TCI Chemical

Product number: B1067
Product name: 3-Bromothiophene
Purity: >97.0%(GC)
Packaging: 25g
Price: $77
Updated: 2025/07/31

TCI Chemical

Product number: B1067
Product name: 3-Bromothiophene
Purity: >97.0%(GC)
Packaging: 250g
Price: $446
Updated: 2025/07/31

Sigma-Aldrich

Product number: 106224
Product name: 3-Bromothiophene
Purity: 97%
Packaging: 100g
Price: $171
Updated: 2025/07/31

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3-Bromothiophene Chemical Properties,Usage,Production

Chemical Properties

clear colourless to slightly yellow liquid. It is not soluble in water, but can dissolve in common organic solvents such as chloroform, benzene, ether, and tetrahydrofuran.

Uses

3-Bromothiophene is used in the preparation of derivatives such as thienylenic alpha, μ-diformyl-alpha-oligothiophenes and 3-lithiothiophene. It is also used in the synthesis of 3-lithiothiophene by reacting with n-butyllithium.

Uses

3-Bromothiophene can be used as a reactant to synthesize:
3,3-Bithiophene via borylation followed by Suzuki coupling.
3-Alkylthiophenes by NiDPPP++ catalyzed cross-coupling with Grignard reagents.
3-Lithiothiophene by treating with n-butyllithium in hexane.
Derivatives of thienylenic α, ω?diformyl?α?oligothiophenes.
N-(2-(3-bromothiophen-2-yl)phenyl)methanesulfonamides by coupling at the 2-position with N-arylmethanesulfonamides, mediated by iodobenzene diacetate (178721).

Preparation

Preparation of 3-bromothiophene using 2,5-dibromothiophene
2,5-Dibromothiophene (121g, 0.5 moles), tris (3,6-dioxaheptyl) amine (1.0g, 0.003 mole), thiophene (500 cm3) and sodium amide (58.5g, 1.5 mole) were successively charged to a flask which had previously been purged with nitrogen. The reaction mixture was stirred and heated under nitrogen at 50-60°C for 6 hours. The product, after work up as described in Example 3, was found to contain 138.5g 3-bromothiophene and 2.6g 2-bromothiophene. The yield of 3-bromothiophene was 85% and the monobromothiophenes were in the ratio of 2 parts 2-bromothiophene to 98 parts 3-bromothiophene.

Reactions

3-Bromothiophene is an electron-rich aromatic hydrocarbon bromide. The bromine atom in it has good electrophilicity. It can perform a Suzuki coupling reaction under the catalysis of metal palladium, and react with different aryl or alkenyl borates. The corresponding substitution products are generated. This reaction is one of the very important methods in organic synthesis, which can build C-C bonds and form complex organic molecular structures.

Synthesis Reference(s)

Journal of the American Chemical Society, 74, p. 2965, 1952 DOI: 10.1021/ja01132a004
Synthetic Communications, 11, p. 25, 1981 DOI: 10.1080/00397918108064278

3-Bromothiophene Preparation Products And Raw materials

Raw materials

Preparation Products

3-Cyanomethylthiophene Thiophene-3-ethanol 3-DODECYLTHIOPHENE METHYL 3-THIOPHENECARBOXYLATE 1-(5-NITRO-3-THIENYL)ETHAN-1-ONE 3-Thiopheneacetic acid 3-Bromomethylthiophene 3-Thiopheneboronic acid 6-(THIOPHEN-3-YL)PYRIDINE-2-CARBALDEHYDE 3-Bromothiophene-2-carbaldehyde 3-BROMOTHIOPHENE-2-CARBONYL CHLORIDE 3-Thienylmethanol THIOPHEN-3-YL-ACETYL CHLORIDE 3-Thienylmethylamine METHYL 3-BROMOTHIOPHENE-2-CARBOXYLATE 3-BROMOTHIOPHENE-2-CARBOXAMIDE 3-Bromothiophene-2-carboxylic acid Ethyl thiophene-3-carboxylate 2-ACETYL-3-BROMOTHIOPHENE

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3-Bromothiophene Suppliers

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View Lastest Price from 3-Bromothiophene manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 3-Bromothiophene 872-31-1
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-05-07

Hebei Chuanghai Biotechnology Co., Ltd

Product: 3-Bromothiophene 872-31-1
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-22

Henan Aochuang Chemical Co.,Ltd.

Product: 3-Bromothiophene 872-31-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-27

872-31-1, 3-BromothiopheneRelated Search:

Thianaphthene Ethidium bromide Tetrahydrothiophene Thifensulfuron Clidinium bromide Thiophene Cephalothin sodium Sodium bromate 4,5-Dibromothiophene-2-sulphonyl chloride 2,3,4-Tribromothiophene 2,3-Dibromothiophene 4-Bromothiophene-2-carboxaldehyde 3-Bromo-2-chlorothiophene Methyl bromide 2,3,5-Tribromothiophene 3,4-Dibromothiophene 2,4-Dibromothiophene 4-BROMO-2,5-DICHLOROTHIOPHENE-3-SULFONYL CHLORIDE

3-bromo-thiophen

beta-Bromothiophene

thiophene,3-bromo-

β-bromothiophene

TIMTEC-BB SBB003930

TIMTEC-BB SBB003931

ALPHA-THIENYL BROMIDE

3-THIENYL BROMIDE

BROMOTHIOPHENE(3-)

3-Bromothiophene99%

3-Bromothiophene, 96+%

3-Bromothiophene,97%

3-BroMothiofuran

3-BroMothiophene, 97% 25ML

3-BROMOTHIOPHENE FOR SYNTHESIS

3-Bromothiophene

3-bromothiophene anhydrous

b-Bromothiophene

Clopidogrel Impurity 75

3-Bromthiophen

3-Bromothiophene, 97%, for synthesis

3-Bromothiophene &gt

3-Bromothiophene ISO 9001：2015 REACH

S0501

3-Bromothiophene pure, 98%

3 - bromine thiophene

DK938

3-Bromothiophene in isooctane

872-31-1

872-31-3

HALOGEN

Building Blocks

Thiophene Derivatives (for Conduting Polymer Research)

Reagents for Conducting Polymer Research

Heterocyclic Building Blocks

Halogenated Heterocycles

Thiophenes

Heterocycles

Halides

Thiophenes & Benzothiophenes

Thiophene&Benzothiophene

Miscellaneous

Thiophene Derivatives (for Conduting Polymer Research)

Functional Materials

Reagents for Conducting Polymer Research

Thiophen

Thiophenes & Benzothiophenes

Thiophenes

Heterocycle-oher series

alkyl bromide

bc0001