T-butyl-3-oxocyclobutanecarboxylate

Product Name: T-butyl-3-oxocyclobutanecarboxylate
CAS No.: 145549-76-4
Chemical Name: T-butyl-3-oxocyclobutanecarboxylate
Synonyms: T-butyl-3-oxocyclobutanecarboxylate;tert-Butyl 3-oxocyclobutanecarboxylate;tert-butyl 3-oxocyclobutane-1-carboxylate;tert-Butyl3-oxocyclobutanecarboxylate,97%;tert-Butyl 3-oxocyclobutanecarboxylate - [B14357];3-Oxo-cyclobutanecarboxylic acid tert-butyl ester;Cyclobutanecarboxylic acid, 3-oxo-, 1,1-diMethylethyl ester
CBNumber: CB72489587
Molecular Formula: C9H14O3
Formula Weight: 170.21
MOL File: 145549-76-4.mol

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T-butyl-3-oxocyclobutanecarboxylate Property

Boiling point:: 230.4±33.0 °C(Predicted)
Density: 1.1g/ml
storage temp.: Sealed in dry,Store in freezer, under -20°C
form: semi-solid
color: Colourless
InChI: InChI=1S/C9H14O3/c1-9(2,3)12-8(11)6-4-7(10)5-6/h6H,4-5H2,1-3H3
InChIKey: JINYZTGTQXDUQR-UHFFFAOYSA-N
SMILES: C1(C(OC(C)(C)C)=O)CC(=O)C1

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Safety

HS Code: 2918300090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B809965
Product name: tert-Butyl 3-oxocyclobutanecarboxylate
Packaging: 50mg
Price: $60
Updated: 2021/12/16

Synthonix

Product number: B14357
Product name: tert-Butyl 3-oxocyclobutanecarboxylate
Purity: 95+%
Packaging: 10g
Price: $50
Updated: 2021/12/16

Synthonix

Product number: B14357
Product name: tert-Butyl 3-oxocyclobutanecarboxylate
Purity: 95+%
Packaging: 1g
Price: $20
Updated: 2021/12/16

Apolloscientific

Product number: OR921343
Product name: tert-Butyl 3-oxocyclobutanecarboxylate
Purity: 95%
Packaging: 5g
Price: $70
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB165567
Product name: tert-Butyl 3-oxocyclobutanecarboxylate
Packaging: 5G
Price: $75
Updated: 2021/12/16

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T-butyl-3-oxocyclobutanecarboxylate Chemical Properties,Usage,Production

Synthesis

23761-23-1

75-65-0

145549-76-4

General procedure for the synthesis of tert-butyl 3-oxocyclobutanecarboxylate from 3-oxocyclobutanecarboxylic acid and tert-butanol: To a solution of commercially available 3-oxocyclobutanecarboxylic acid (11.4 g, 100 mmol) in anhydrous dichloromethane (DCM, 100 mL) was added N,N'-dicyclohexylcarbodiimide (DCC, 31 g, 150 mmol) and tert-butanol (8.9 g, 120 mmol). 120 mmol). The reaction mixture was stirred at room temperature overnight. After completion of the reaction, the reaction was quenched with deionized water and the aqueous phase was extracted with DCM. The organic layers were combined, washed with saturated saline, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to afford the target product tert-butyl 3-oxocyclobutanecarboxylate (15.1 g, 89% yield).

References

[1] Patent: WO2014/131855, 2014, A1. Location in patent: Page/Page column 77
[2] Journal of Medicinal Chemistry, 2016, vol. 59, # 19, p. 8967 - 9004
[3] Journal of Organic Chemistry, 1993, vol. 58, # 1, p. 100 - 110
[4] Journal of Medicinal Chemistry, 2017, vol. 60, # 2, p. 627 - 640
[5] Patent: US2009/298894, 2009, A1. Location in patent: Page/Page column 44

T-butyl-3-oxocyclobutanecarboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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T-butyl-3-oxocyclobutanecarboxylate Suppliers

China 98 India 1 United Kingdom 1 United States 7 Global 107

Aladdin Scientific

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View Lastest Price from T-butyl-3-oxocyclobutanecarboxylate manufacturers

Henan Fengda Chemical Co., Ltd

Product: T-butyl-3-oxocyclobutanecarboxylate 145549-76-4
Price: US $200.00-1.00/KG
Min. Order: 1KG
Purity: 99%, 99.5% Sublimated
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-30

Career Henan Chemical Co

Product: T-butyl-3-oxocyclobutanecarboxylate 145549-76-4
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 10000KGS
Release date: 2020-01-11

145549-76-4, T-butyl-3-oxocyclobutanecarboxylateRelated Search:

(3-OXO-CYCLOHEXYL)-CARBAMIC ACID TERT-BUTYL ESTER Methyl 3-hydroxycyclobuta... METHYL 3-OXOCYCLOBUTANECARBOXYLATE BENZYL 3-OXOCYCLOBUTYLCARBAMATE 3-Hydroxy-cyclobutanecarboxylic acid ethyl ester 3-HYDROXYCYCLOBUTANECARBOXYLIC ACID tert-butyl 3-hydroxycyclobutanecarboxylate Cyclobutanecarboxylic acid, 3-methylene-, methyl ester (6CI,8CI,9CI) Carbamic acid, (3-oxocyclobutyl)-, 1,1-dimethylethyl ester (9CI) ETHYL 3-OXO CYCLOBUATNE CARBOXYLATE 3-Oxocyclobutanecarboxylic acid

tert-Butyl 3-oxocyclobutanecarboxylate

3-Oxo-cyclobutanecarboxylic acid tert-butyl ester

tert-butyl 3-oxocyclobutane-1-carboxylate

Cyclobutanecarboxylic acid, 3-oxo-, 1,1-diMethylethyl ester

T-butyl-3-oxocyclobutanecarboxylate

tert-Butyl3-oxocyclobutanecarboxylate,97%

tert-Butyl 3-oxocyclobutanecarboxylate - [B14357]

145549-76-4