ChemicalBook > CAS DataBase List > O-(2-AMinoethyl)-O'-[2-(Boc-aMino)ethyl]tetraethylene Glycol

O-(2-AMinoethyl)-O'-[2-(Boc-aMino)ethyl]tetraethylene Glycol

Product Name
O-(2-AMinoethyl)-O'-[2-(Boc-aMino)ethyl]tetraethylene Glycol
CAS No.
189209-27-6
Chemical Name
O-(2-AMinoethyl)-O'-[2-(Boc-aMino)ethyl]tetraethylene Glycol
Synonyms
NH2-PEG5-NHBOC;BOC-NH-PEG5-NH2;NHBoc-PEG5-amine;PROTAC Linker 17;Boc-NH-PEG(4)-NH2;NH2-PEG5-C2-NH-Boc;BOC-N-AMIDO-PEG5-NH2;BOC-AMINO-PEG5-AMINE;Boc-N-amido-PEG5-Azide;Boc-N-amido-PEG5-Amine
CBNumber
CB72557907
Molecular Formula
C17H36N2O7
Formula Weight
380.48
MOL File
189209-27-6.mol
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O-(2-AMinoethyl)-O'-[2-(Boc-aMino)ethyl]tetraethylene Glycol Property

storage temp. 
2-8°C(protect from light)
solubility 
Soluble in Water, DMSO, DCM, DMF
form 
Liquid
color 
Colorless to light yellow
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Safety

HS Code 
2918999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
A608875
Product name
O-(2-Aminoethyl)-O’-[2-(Boc-amino)ethyl]tetraethyleneGlycol
Packaging
50mg
Price
$1260
Updated
2021/12/16
AK Scientific
Product number
0323AP
Product name
BocNH-PEG5-CH2CH2NH2
Packaging
5g
Price
$1396
Updated
2021/12/16
Iris Biotech GmbH
Product number
PEG7890
Product name
Boc-NH-PEG(5)-NH2
Packaging
5G
Price
$2160
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB73001
Product name
BocNH-PEG5-CH2CH2NH2
Packaging
100mg
Price
$140
Updated
2021/12/16
ChemPep
Product number
282409
Product name
Boc-NH-PEG5-CH2CH2NH2
Packaging
5g
Price
$1200
Updated
2021/12/16
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O-(2-AMinoethyl)-O'-[2-(Boc-aMino)ethyl]tetraethylene Glycol Chemical Properties,Usage,Production

Description

t-Boc-N-Amido-PEG5-amine is a Boc protected PEG linker containing an free amino group and5 PEG units. The hydrophilic PEG spacer increases solubility in aqueous media. The amino group is reactive with carboxylic acids, activated NHS esters. The Boc group can be deprotected under mild acidic conditions to free the amine.

Uses

As a polyethyleneglycol (PEG) derivative, O-(2-AMinoethyl)-O'-[2-(Boc-aMino)ethyl]tetraethylene Glycol can be used in the preparation of novel biochip technology for detection of explosives-TNT. It is also used as a reagent in the synthesis of chemical inducer of dimeriza tions (CID) to identify the protein target of inhibitors of Toxoplasma gondii invasion.

Synthesis

911209-07-9

189209-27-6

General procedure for the synthesis of tert-butyl (17-amino-3,6,9,12,15-pentaoxaheptadecyl)carbamate from (17-azido-3,6,9,12,15-pentaoxaheptadecyl)carbamate: Compound 6 (5-PEG-Boc-Amino azide, 2.90 g, 8.0 mmol) was dissolved in a Parr reaction flask in 100 ml of ethyl acetate and 0.25 g of 10% Pd/C catalyst was added. The reaction mixture was stirred overnight under hydrogen atmosphere. Upon completion of the reaction, the reaction mixture was diluted with 200 ml of ethyl acetate and filtered through a diatomaceous earth pad to remove the catalyst. The filtrate was concentrated under reduced pressure to remove the solvent to give 2.41 g of crude product. The crude product was purified by silica gel column chromatography, first eluting using a mixed solvent system of 1% NH4OH/15% MeOH/84% CH2Cl2, and then switching to a mixed solvent system of 1% NH4OH/25% MeOH/74% CH2Cl2, and the target fractions were collected to give 1.37 g of purified product. The purified product was dissolved in toluene and concentrated again under reduced pressure to give 1.21 g (40% yield) of the target compound 7.

IC 50

PEGs; Alkyl/ether

References

[1] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 1, p. 586 - 590
[2] Organic and Biomolecular Chemistry, 2009, vol. 7, # 15, p. 3049 - 3060
[3] Synlett, 2015, vol. 26, # 19, p. 2707 - 2713
[4] Patent: US7230101, 2007, B1. Location in patent: Page/Page column 60; 79

O-(2-AMinoethyl)-O'-[2-(Boc-aMino)ethyl]tetraethylene Glycol Preparation Products And Raw materials

Raw materials

Preparation Products

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O-(2-AMinoethyl)-O'-[2-(Boc-aMino)ethyl]tetraethylene Glycol Suppliers

Canada 1 China 105 India 1 United Kingdom 2 United States 9 Global 118
J & K SCIENTIFIC LTD.
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18210857532; 18210857532
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ChemPep, Inc.
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Bide Pharmatech Ltd.
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View Lastest Price from O-(2-AMinoethyl)-O'-[2-(Boc-aMino)ethyl]tetraethylene Glycol manufacturers

LAURENT
Product
BocNH-PEG5-CH2CH2NH2 189209-27-6
Price
US $319.00/g
Min. Order
1g
Purity
98%
Supply Ability
500kg
Release date
2025-11-15
XIAMEN SINOPEG BIOTECH CO., LTD.
Product
tert-butyl (17-amino-3,6,9,12,15-pentaoxaheptadecyl)carbamate 189209-27-6
Price
US $0.00-0.00/g
Min. Order
1g
Purity
98%
Supply Ability
1g/bottle, 10g/bottle, 100g/bottle
Release date
2025-09-12
Xian confluore Biological Technology Co., Ltd.
Product
NHBoc-PEG5-amine 189209-27-6
Price
US $0.00/mg
Min. Order
500mg
Purity
>98.00%
Supply Ability
500mg
Release date
2024-04-02

189209-27-6, O-(2-AMinoethyl)-O'-[2-(Boc-aMino)ethyl]tetraethylene GlycolRelated Search:

FMOC-15-AMINO-4,7,10,13-TETRAOXAPENTADECANOIC ACID Amino-PEG4-acid H2N-PEG8-tBu 2,5,8,11,14,17,20,23,26,29-Decaoxahentriacontane-31-thiol N3-PEG3-tBu 2,5,8,11,14,17,20-Heptaoxadocosan-22-amine HO-PEG10-tBu 2-[2-[2-[2-[2-(BENZYLOXY)ETHOXY]ETHOXY]ETHOXY]ETHOXY]ETHANOL O-(2-AMINOETHYL)-O-(2-AZIDOETHYL)HEPTAETHYLENE GLYCOL 5,8,11,14-Tetraoxa-2-azahexadecanoic acid,16-amino-,1,1-dimethyl ester O-(2-AMINOETHYL)-O'-(2-(BOC-AMINO)ETHYL) HS-PEG4-tBu 2,5,8,11,14,17,20,23,26-Nonaoxaoctacosan-28-amine 17-Azido-3,6,9,12,15-pentaoxaheptadecan-1-amine 2-[2-(2-AMINOETHOXY)ETHOXY]ETHANOL α,ω-dipropionic acid tetraethylene glycol DODECAETHYLENE GLYCOL MONOMETHYL ETHER 1,14-diamino-3,6,9,12-tetraoxatetradecane

  • t-boc-N-amido-PEG6-Amine
  • t-boc-N-amido-PEG5-Amine
  • t-boc-N-amido-PEG5-Azide
  • tert-Butyl (17-amino-3,6,9,12,15-pentaoxaheptadecyl)carbamate
  • Boc-N-amido-PEG5-Amine
  • Boc-N-amido-PEG5-Azide
  • O-(2-AMinoethyl)-O'-[2-(Boc-aMino)ethyl]tetraethylene Glycol
  • BocNH-PEG<SUB>5</SUB>-CH<SUB>2</SUB>CH<SUB>2</SUB>NH<SUB>2</SUB>
  • 19-AMino-5,8,11,14,17-pentaoxa-2-azanonadecanoic Acid 1,1-DiMethylethyl Ester
  • Boc-aMino-PEG-aMine (n=5)
  • Boc-NH-PEG(4)-NH2
  • Boc-NH-PEG(4)-NH2(19atoMs)
  • BOC-N-AMIDO-PEG5-NH2
  • BOC-NH-PEG5-NH2
  • tert-butyl N-[2-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy] ethoxy]ethoxy]ethyl]carbamate
  • N1-Boc-3,6,9,12,15-pentaoxaheptadecane-1,17-diamine
  • t-BocNH-PEG5-CH2CH2NH2
  • NH2-PEG5-C2-NH-Boc
  • NHBoc-PEG5-amine
  • BOC-AMINO-PEG5-AMINE
  • PROTAC Linker 17
  • 5,8,11,14,17-Pentaoxa-2-azanonadecanoic acid, 19-amino-, 1,1-dimethylethyl ester
  • t-Boc-Amido-PEG6-Amine
  • BocNH-PEG5-CH2CH2NH2/5,8,11,14,17-Pentaoxa-2-azanonadecanoic acid, 19-amino-, 1,1-dimethylethyl ester
  • NH2-PEG5-NHBOC
  • O-(2-Aminoethyl)-O’-[2-(Boc-amino)ethyl]tetraethylene Glycol
  • O-(2-Aminoethyl)-O′-[2-(Boc-amino)ethyl]tetraethylene Glycol, CAS 189209-27-6
  • 189209-27-6
  • C17H36N2O7
  • PEGylation Reagents
  • Aliphatics
  • Amines
  • Intermediates
  • Polyethyleneglycol Derivatives
  • peg