ChemicalBook > CAS DataBase List > 3-Carboxyphenylboronic acid pinacol ester

3-Carboxyphenylboronic acid pinacol ester

Product Name: 3-Carboxyphenylboronic acid pinacol ester
CAS No.: 269409-73-6
Chemical Name: 3-Carboxyphenylboronic acid pinacol ester
Synonyms: CAS:269409-73-6;2-dioxaborolan-2-yl)benzoic acid;Tranexamic Acid Impurity 28-13C2;3-Carboxyphenylboronic acid picol ester;3-CARBOXYPHENYLBORONIC ACID, PINACOL ESTER;3-Carboxybenzeneboronic acid, pinacol ester;3-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid;3-Carboxyphenylboronic acid, pinacol ester - [C2162];3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoicaci;3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZOIC ACID
CBNumber: CB7265707
Molecular Formula: C13H17BO4
Formula Weight: 248.08
MOL File: 269409-73-6.mol

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3-Carboxyphenylboronic acid pinacol ester Property

Melting point:: 206-211 °C
Boiling point:: 395.1±25.0 °C(Predicted)
Density: 1.15±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
pka: 4.20±0.10(Predicted)
form: Powder
color: White
Water Solubility: Insoluble
InChI: InChI=1S/C13H17BO4/c1-12(2)13(3,4)18-14(17-12)10-7-5-6-9(8-10)11(15)16/h5-8H,1-4H3,(H,15,16)
InChIKey: OPWAPCOSDAFWFB-UHFFFAOYSA-N
SMILES: C(O)(=O)C1=CC=CC(B2OC(C)(C)C(C)(C)O2)=C1
CAS DataBase Reference: 269409-73-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 37/39-26
WGK Germany: 3
TSCA: No
HS Code: 29310099

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H227Combustible liquid

H302Harmful if swallowed

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P403+P235Store in a well-ventilated place. Keep cool.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 574694
Product name: 3-Carboxyphenylboronic acid pinacol ester
Purity: 97%
Packaging: 1g
Price: $27.46
Updated: 2025/07/31

TCI Chemical

Product number: T3162
Product name: 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic Acid
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $22
Updated: 2025/07/31

TCI Chemical

Product number: T3162
Product name: 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic Acid
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $57
Updated: 2025/07/31

Strem Chemicals

Product number: 05-1036
Product name: 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid, min. 97%
Packaging: 1g
Price: $68
Updated: 2024/03/01

Strem Chemicals

Product number: 05-1036
Product name: 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid, min. 97%
Packaging: 5g
Price: $271
Updated: 2024/03/01

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3-Carboxyphenylboronic acid pinacol ester Chemical Properties,Usage,Production

Chemical Properties

almost white to light beige crystalline powder

Uses

3-Carboxyphenylboronic Acid Pinacol Ester is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Synthesis

585-76-2

73183-34-3

269409-73-6

After degassing into 1,4-dioxane (0.1 M) under nitrogen atmosphere, m-bromobenzoic acid (1 eq.), pinacol ester of bisboronic acid (1.5 eq.) and potassium acetate (4.4 eq.) were added. The mixture was degassed again followed by the addition of PdCl2 (dppf) (5%). The resulting solution was heated to 110°C for overnight reaction. Upon completion of the reaction, the solvent was removed under vacuum to give a dark colloidal residue. This residue was dissolved in ethyl acetate and water to separate the organic layer. The aqueous phase was further extracted with ethyl acetate (2×). The combined organic layers were washed with 2M HCl, dried over MgSO4 and concentrated in vacuum to give a dark brown product. To purify the product, column chromatography (petroleum ether/ethyl acetate elution) was used. The 3-carboxyphenylboronic acid pinacol ester prepared by Suzuki coupling reaction was a light brown solid in 89% yield.1H NMR (400 MHz, CDCl3) δ 8.57 (s, 1H), 8.19 (ddd, J = 21.9, 1.18, 10.1 Hz, 1H), 8.09-7.98 (m, 1H), 7.57-7.38 (m, 1H), 1.37 (m, 1H), 7.57-7.38 (m, 1H). 1H), 1.37 (s, 12H).13C NMR (101 MHz, CDCl3) δ 171.66, 139.98, 136.60, 132.84, 128.71, 127.93, 84.21, 24.89.LCMS (ESI) m/z 249.2 [M + H]+.

References

[1] Patent: WO2016/198507, 2016, A1. Location in patent: Page/Page column 39; 49

3-Carboxyphenylboronic acid pinacol ester Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-Carboxyphenylboronic acid pinacol ester manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 3-Carboxyphenylboronic acid pinacol ester 269409-73-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

Zhuozhou Wenxi import and Export Co., Ltd

Product: 3-Carboxyphenylboronic acid pinacol ester 269409-73-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

Career Henan Chemical Co

Product: 3-Carboxyphenylboronic acid pinacol ester 269409-73-6
Price: US $8.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10tons
Release date: 2018-12-25

269409-73-6, 3-Carboxyphenylboronic acid pinacol esterRelated Search:

2-Carboxybenzaldehyde Bis(pinacolato)diboron Tris(trimethylsilyl)phosphate 4-Bromomethylbenzoic acid Diethyl phthalate 3-Carboxyphenylboronic acid 4-(Chloromethyl)benzoic acid 4-Hydroxyphenylboronic acid 2,2,4-Trimethyl-1,3-pentanediol monoisobutyrate 4-Carboxyphenylboronic acid 4-(Aminomethyl)benzoic acid Propyleneglycol alginate Pinacol Phenylboronic acid 2-(Trifluoromethyl)benzoic acid Methyl acrylate p-Toluic acid m-Toluic acid

3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZOIC ACID

3-CARBOXYPHENYLBORONIC ACID, PINACOL ESTER

3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzoicacid,min.97%

3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZOIC ACID, MIN. 97%

3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid,97%

3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid3-Carboxyphenylboronic acid pinacol ester

2-dioxaborolan-2-yl)benzoic acid

3-Carboxybenzeneboronic acid, pinacol ester

3-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)benzoic acid, 97% 5GR

3-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid

3-Carboxyphenylboronic acid pinacol ester 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid

3-Carboxyphenylboronic acid picol ester

Benzoic acid, 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-

3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoicaci

2-(3-Carboxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Tranexamic Acid Impurity 28-13C2

CAS:269409-73-6

3-Carboxyphenylboronic acid, pinacol ester - [C2162]

269409-73-6

Organometallic Reagents

Boronate Esters

Boronic Acids and Derivatives

Aryl

organic or inorganic borate

Acids and Derivatives

Boron, Nitrile, Thio,& TM-Cpds

Boronic acids

CHIRAL CHEMICALS