ChemicalBook > CAS DataBase List > PFK-015

PFK-015

Product Name
PFK-015
CAS No.
4382-63-2
Chemical Name
PFK-015
Synonyms
CS-1317;PFK-015;PFK15 ，S7289;PFK15【SML1009】;PFK15 (PFK-015);PFK-015, 10 mM in DMSO;PFKFB3 Inhibitor II, PFK15;PFK015;PFK15;PFK 15;PFK-15;1-(4-Pyridinyl)-3-(2-quinolinyl)-2-propen-1-one;2-Propen-1-one, 1-(4-pyridinyl)-3-(2-quinolinyl)-
CBNumber
CB72705092
Molecular Formula
C17H12N2O
Formula Weight
260.29
MOL File
4382-63-2.mol
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PFK-015 Property

Boiling point:
464.4±45.0 °C(Predicted)
Density 
1.237±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
solubility 
DMSO: soluble10mg/mL, clear
form 
powder
pka
3.11±0.61(Predicted)
color 
white to beige
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1009
Product name
PFK15
Purity
≥98% (HPLC)
Packaging
5mg
Price
$123
Updated
2025/07/31
Sigma-Aldrich
Product number
SML1009
Product name
PFK15
Purity
≥98% (HPLC)
Packaging
25mg
Price
$489
Updated
2025/07/31
Cayman Chemical
Product number
17689
Product name
PFK15
Purity
≥95%
Packaging
5mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
17689
Product name
PFK15
Purity
≥95%
Packaging
10mg
Price
$75
Updated
2024/03/01
Cayman Chemical
Product number
17689
Product name
PFK15
Purity
≥95%
Packaging
25mg
Price
$165
Updated
2024/03/01
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PFK-015 Chemical Properties,Usage,Production

Description

PFK15 (4382-63-2) is an inhibitor of the metabolic enzyme 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3).? PFKFB3 is constitutively expressed by neoplastic cells and is required for the high glycolytic rate (Warburg Effect) of these cells. PFK15 inhibits PFKFB3 (IC50?= 207 nM) without inhibiting 96 other kinases.1?PFK15 was able to potently inhibit glucose and F26BP uptake. It induced apoptosis and reduced tumor growth?in vitro?and?in vivo.?PFK15 has been shown to inhibit tumor growth in various cancer models.2,3

Uses

PFK 15 is a novel inhibitor of glycolytic enzyme 6-phosphofructo-2-kinase/2,6-bisphosphatase 3 (PFKFB3). It suppresses the glucose uptake and growth of Lewis lung carcinomas in syngeneic mice, and induces apoptosis in abnormal cells.

in vivo

PFK-015 impeds ESCC tumor growth in immunodeficient in vivo models[1].
? ? PFK-015 (0-12.5 μM, 48 h) induces tumor PD-L1 expression[1].
? ? PFK-015 (0-12.5 μM, 48 h) can cause a downregulation of immune activity against tumor cells mediated by CD8 + T cells[1].
? ? PFK-015 enhances the efficacy of ESCC by enhancing CD8 + T-cell activity combining PD-1 mAb in immunocompetent mouse models such as C57BL/6 and hu-PBMC-NOG[1].
? PFK-015 (iv, 5 mg/kg) has a satisfactory half-life, exposure, tissue distribution and reasonable clearance[2].

storage

Store at -20°C

References

[1] BRIAN F CLEM. Targeting 6-phosphofructo-2-kinase (PFKFB3) as a therapeutic strategy against cancer.[J]. Molecular Cancer Therapeutics, 2013, 12 8: 1461-1470. DOI:10.1158/1535-7163.mct-13-0097
[2] WEI ZHU. PFK15, a Small Molecule Inhibitor of PFKFB3, Induces Cell Cycle Arrest, Apoptosis and Inhibits Invasion in Gastric Cancer[J]. PLoS ONE, 2016, 11 1. DOI:10.1371/journal.pone.0163768
[3] HUI-MIN LI. Blockage of glycolysis by targeting PFKFB3 suppresses tumor growth and metastasis in head and neck squamous cell carcinoma.[J]. Progress in brain research, 2017, 5 1: 7. DOI:10.1186/s13046-016-0481-1

PFK-015 Preparation Products And Raw materials

Raw materials

Preparation Products

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PFK-015 Suppliers

China 110 India 1 United Kingdom 2 United States 12 Global 125
Novachemistry
Tel
44-20819178-90 02081917890
Fax
(0)2080432064
Email
info@novachemistry.com
Country
United Kingdom
ProdList
4381
Advantage
58
Tocris Bioscience
Tel
--
Fax
--
Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5726
Advantage
77
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View Lastest Price from PFK-015 manufacturers

Career Henan Chemical Co
Product
PFK-015 4382-63-2
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
200kg
Release date
2019-12-25

4382-63-2, PFK-015Related Search:

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  • PFK015;PFK15;PFK 15;PFK-15
  • CS-1317
  • 2-Propen-1-one, 1-(4-pyridinyl)-3-(2-quinolinyl)-
  • 1-(4-Pyridinyl)-3-(2-quinolinyl)-2-propen-1-one PFK15
  • 1-(Pyridin-4-yl)-3-(quinolin-2-yl)prop-2-en-1-one
  • PFK15 (PFK-015)
  • PFK-015
  • 1-(4-Pyridinyl)-3-(2-quinolinyl)-2-propen-1-one
  • (E)-1-(pyridin-4-yl)-3-(quinolin-2-yl)prop-2-en-1-one
  • PFK-015, 10 mM in DMSO
  • PFKFB3 Inhibitor II, PFK15
  • PFK15【SML1009】
  • PFK15 ，S7289
  • 4382-63-2
  • Inhibitors