PFK-015

Product Name: PFK-015
CAS No.: 4382-63-2
Chemical Name: PFK-015
Synonyms: CS-1317;PFK-015;PFK15 (PFK-015);PFK015;PFK15;PFK 15;PFK-15;1-(4-Pyridinyl)-3-(2-quinolinyl)-2-propen-1-one;2-Propen-1-one, 1-(4-pyridinyl)-3-(2-quinolinyl)-;1-(Pyridin-4-yl)-3-(quinolin-2-yl)prop-2-en-1-one;(E)-1-(pyridin-4-yl)-3-(quinolin-2-yl)prop-2-en-1-one;1-(4-Pyridinyl)-3-(2-quinolinyl)-2-propen-1-one PFK15
CBNumber: CB72705092
Molecular Formula: C17H12N2O
Formula Weight: 260.29
MOL File: 4382-63-2.mol

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PFK-015 Property

Boiling point:: 464.4±45.0 °C(Predicted)
Density: 1.237±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
solubility: DMSO: soluble10mg/mL, clear
form: powder
pka: 3.11±0.61(Predicted)
color: white to beige
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37/39
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1009
Product name: PFK15
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $120
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML1009
Product name: PFK15
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $476
Updated: 2024/03/01

Cayman Chemical

Product number: 17689
Product name: PFK15
Purity: ≥95%
Packaging: 5mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 17689
Product name: PFK15
Purity: ≥95%
Packaging: 10mg
Price: $75
Updated: 2024/03/01

Cayman Chemical

Product number: 17689
Product name: PFK15
Purity: ≥95%
Packaging: 25mg
Price: $165
Updated: 2024/03/01

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PFK-015 Chemical Properties,Usage,Production

Description

PFK15 (4382-63-2) is an inhibitor of the metabolic enzyme 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3).? PFKFB3 is constitutively expressed by neoplastic cells and is required for the high glycolytic rate (Warburg Effect) of these cells. PFK15 inhibits PFKFB3 (IC50?= 207 nM) without inhibiting 96 other kinases.1?PFK15 was able to potently inhibit glucose and F26BP uptake. It induced apoptosis and reduced tumor growth?in vitro?and?in vivo.?PFK15 has been shown to inhibit tumor growth in various cancer models.2,3

Uses

PFK 15 is a novel inhibitor of glycolytic enzyme 6-phosphofructo-2-kinase/2,6-bisphosphatase 3 (PFKFB3). It suppresses the glucose uptake and growth of Lewis lung carcinomas in syngeneic mice, and induces apoptosis in abnormal cells.

storage

Store at -20°C

References

1) Clem?et al.?(2013),?Targeting 6-phosphofructo-2-kinase (PFKFB3) as a therapeutic strategy against cancer; Mol. Cancer Ther.?12?1461 2) Zhu?et al. (2016),?PFK15,a Small Molecule Inhibitor of PFKFB3, Induces Cell Cycle Arrest, Apoptosis and Inhibits Invasion in Gastric Cancer; PLoS One?11?e0163768 3) Li?et al. (2017),?Blockage of glycolysis by targeting PFKFB3 suppresses tumor growth and metastasis in head and neck squamous cell carcinoma; J. Exp. Clin. Cancer Res.?36?7

PFK-015 Preparation Products And Raw materials

Raw materials

Preparation Products

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PFK-015 Suppliers

China 88 India 1 United Kingdom 2 United States 12 Global 103

Target molecule Corp.

Tel: 857-239-0968
Fax: 857-239-8801
Email: service1@targetmol.com
Country: United States
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Advantage: 60

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4660
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32165
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

BOC Sciences

Tel: +1-631-485-4226
Fax: 1-631-614-7828
Email: inquiry@bocsci.com
Country: United States
ProdList: 19553
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

Focus Biomolecules

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Cayman Chemical Company

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MedChemExpress

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Riedel-de Haen AG

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AK Scientific, Inc.

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Country: United States
ProdList: 6347
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View Lastest Price from PFK-015 manufacturers

Career Henan Chemical Co

Product: PFK-015 4382-63-2
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-25

4382-63-2, PFK-015Related Search:

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PFK015;PFK15;PFK 15;PFK-15

CS-1317

2-Propen-1-one, 1-(4-pyridinyl)-3-(2-quinolinyl)-

1-(4-Pyridinyl)-3-(2-quinolinyl)-2-propen-1-one PFK15

1-(Pyridin-4-yl)-3-(quinolin-2-yl)prop-2-en-1-one

PFK15 (PFK-015)

PFK-015

1-(4-Pyridinyl)-3-(2-quinolinyl)-2-propen-1-one

(E)-1-(pyridin-4-yl)-3-(quinolin-2-yl)prop-2-en-1-one

4382-63-2

Inhibitors