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Madecassic acid

Product Name
Madecassic acid
CAS No.
18449-41-7
Chemical Name
Madecassic acid
Synonyms
Madecasoside;MADECASSIC ACID;MADECASSIC ACID(P);Madecassic acid-RM;Hydroxyasiatic acid;Hydroxy asiaticoside;6-Hydroxyasiatic acid;Madecassic Acid (97%);Brahmic acid 18449-41-7;6BETA-HYDROXYASIATIC ACID
CBNumber
CB7280283
Molecular Formula
C30H48O6
Formula Weight
504.71
MOL File
18449-41-7.mol
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Madecassic acid Property

Melting point:
270°C (dec.)
Boiling point:
641.7±55.0 °C(Predicted)
Density 
1.23±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO (Sparingly), Methanol (Slightly, Heated)
form 
Solid
pka
4.63±0.70(Predicted)
color 
White to Pale Red
InChI
InChI=1/C30H48O6/c1-16-9-10-30(25(35)36)12-11-28(5)18(22(30)17(16)2)7-8-21-26(3)13-20(33)24(34)27(4,15-31)23(26)19(32)14-29(21,28)6/h7,16-17,19-24,31-34H,8-15H2,1-6H3,(H,35,36)/t16-,17+,19-,20-,21-,22+,23-,24+,26-,27+,28-,29-,30+/s3
InChIKey
PRAUVHZJPXOEIF-MRQYELSVNA-N
SMILES
C[C@]12C[C@@H](O)[C@H](O)[C@@](C)(CO)[C@]1([H])[C@H](O)C[C@]1([C@@]3(CC[C@]4(CC[C@@H](C)[C@H](C)[C@@]4([H])C3=CC[C@]21[H])C(=O)O)C)C |&1:1,3,5,7,11,13,16,17,20,23,25,27,32,r|
LogP
4.321 (est)
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Safety

Hazard Codes 
Xi
Safety Statements 
24/25
HS Code 
29389090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P391Collect spillage. Hazardous to the aquatic environment

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
11854
Product name
Madecassic Acid
Purity
≥95%
Packaging
100mg
Price
$36
Updated
2024/03/01
Cayman Chemical
Product number
11854
Product name
Madecassic Acid
Purity
≥95%
Packaging
1g
Price
$179
Updated
2024/03/01
Cayman Chemical
Product number
11854
Product name
Madecassic Acid
Purity
≥95%
Packaging
250mg
Price
$81
Updated
2024/03/01
Cayman Chemical
Product number
11854
Product name
Madecassic Acid
Purity
≥95%
Packaging
500mg
Price
$117
Updated
2024/03/01
TRC
Product number
M107500
Product name
MadecassicAcid(97%)
Packaging
250mg
Price
$265
Updated
2021/12/16
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Madecassic acid Chemical Properties,Usage,Production

Description

Madecassic acid is a triterpenoid that has been found in C. asiatica and has diverse biological activities. It inhibits LPS-induced production of nitric oxide (NO), prostaglandin E2 (PGE2; ), TNF-α, IL-1β, and IL-6 in RAW 264.7 macrophages when used at a concentration of 150 μg/ml. Madecassic acid (0.05 and 0.1% in the diet) decreases plasma levels of fibrinogenin and triglycerides, as well as heart and kidney levels of reactive oxygen species (ROS), in a mouse model of diabetes induced by streptozotocin (STZ; ). It decreases tumor growth in a CT26 murine colon cancer model in a dose-dependent manner.

Chemical Properties

White powder

Uses

wound healing

Uses

Madecassic Acid is a terpenoid with an ursane skeleton isolated from Centella asiatica. Madecassic Acid displays anti-inflammatory properties as a result of iNOS, COX-2, TNF-alpha, IL-1beta, and IL-6 inhibition via the downregulation of NF-kappaB activation in RAW 264.7 macrophage cells. Madecassic Acid is found in cosmetic products due to its skin-protective activities.

Definition

ChEBI: A pentacyclic triterpenoid that is ursane substituted by a carboxy group at position 28 and hydroxy groups at positions 2, 3, 6 and 23 (the 2alpha,3beta,6beta stereoisomer).

Madecassic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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Madecassic acid Suppliers

Canada 1 China 292 Europe 2 Germany 3 India 1 United Kingdom 6 United States 20 Global 325
BOC Sciences
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View Lastest Price from Madecassic acid manufacturers

Chongqing Zhihe Biopharmaceutical Co., Ltd.
Product
Madecassic acid 18449-41-7
Price
US $0.00-0.00/kg
Min. Order
0.10000000149011612kg
Purity
≥98%HPLC
Supply Ability
20tons
Release date
2024-01-05
BINBO BIOLOGICAL CO.,LTD
Product
Madecassic acid 18449-41-7
Price
US $0.00/kg
Min. Order
1kg
Purity
>95%
Supply Ability
1000 kg
Release date
2024-04-09
Hebei Kingfiner Technology Development Co.Ltd
Product
Madecassic acid 18449-41-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
500000kg
Release date
2023-05-29

18449-41-7, Madecassic acidRelated Search:

Ethyl 2-(Chlorosulfonyl)acetate ORIENTIN AURANTIO-OBTUSIN CALYCOSIN Stearic acid Centella asiatica extract Asiaticoside Citric acid Folic acid Ascoric Acid Asiatic acid 3,3,5,5-TETRAMETHYLCYCLOHEXANOL Madecassic acid Centella asiatica whole plant MADECASSIC ACID(SECONDARY STANDARD) MADECASSIC ACID(SH) MADECASSIC ACID 95% MADECASSIC ACID(PRIMARY STANDARD)

  • (2alpha,3beta,4alpha,6beta)-2,3,6,23-tetrahydroxy-urs-12-en-28-oic acid
  • MADECASSIC ACID
  • Urs-12-en-28-oic acid, 2,3,6,23-tetrahydroxy-, (2.alpha.,3.beta.,4.alpha.,6.beta.)-
  • (1S,2R,4aS,6aS,6aS,6bR,8R,8aR,9R,10R,11R,12aR,14bR)-8,10,11-trihydroxy -9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-2,3,4,5,6,6a,7,8,8a,10,1 1,12,13,14b-tetradecahydro-1H-picene-4a-carboxylic acid
  • Hydroxy asiaticoside
  • MADECASSIC ACID(P)
  • 6BETA-HYDROXYASIATIC ACID
  • 2α,3β,6β,23-Tetrahydroxyurs-12-en-28-oic acid
  • 6-Hydroxyasiatic acid
  • Madecasoside
  • Madecassic acid, 98%, from Centella asiatica (L.) Urb.
  • Madecassic acid, froM Centella asiatica
  • Urs-12-en-28-oic acid,2,3,6,23-tetrahydroxy-, (2a,3b,4a,6b)-
  • Brahmic acid 18449-41-7
  • Madecassic Acid (97%)
  • Urs-12-en-28-oic acid, 2,3,6,23-tetrahydroxy-, (2α,3β,4α,6β)-
  • (1S,2R,4aS,6aS,6bR,8R,9R,10R,11R,12aR)-8,10,11-trihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylic acid
  • (1S,2R,4aS,6aS,6bR,8R,8aR,9R,10R,11R,12aR,12bR,14bS)-8,10,11-Trihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylic acid
  • Hydroxycentella glycoside
  • Madecassic acid/Madecassoide
  • Hydroxyasiatic acid
  • Madecassic acid-RM
  • 18449-41-7
  • C30H48O6
  • Inhibitors
  • Cofactor
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • Miscellaneous Natural Products
  • The group of Asiaticoside