ChemicalBook > CAS DataBase List > Bis-PEG4-acid

Bis-PEG4-acid

Product Name
Bis-PEG4-acid
CAS No.
96517-92-9
Chemical Name
Bis-PEG4-acid
Synonyms
Di-Acid-PEG3;Bis-PEG3-COOH;Bis-PEG3-acid;COOH-PEG2-COOH;Bis-PEG3-acid ，S1350;HOOCCH2CH2O-PEG2-CH2CH2COOH;4,7,10-trioxa-tridecanedioic acid;3,3'-[oxybis(ethane-2,1-diyloxy)]dipropanoic acid;Propanoic acid, 3,3'-[oxybis(2,1-ethanediyloxy)]bis-;3-[2-[2-(2-carboxyethoxy)ethoxy]ethoxy]propanoic acid
CBNumber
CB73051642
Molecular Formula
C10H18O7
Formula Weight
250.25
MOL File
96517-92-9.mol
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Bis-PEG4-acid Property

Boiling point:
445.4±40.0 °C(Predicted)
Density 
1.239±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
Soluble in Water, DMSO, DMF
pka
3.97±0.10(Predicted)
form 
Solid-Liquid Mixture
color 
Colorless to light yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
P999013
Product name
Bis-PEG3-acid
Packaging
10mg
Price
$50
Updated
2021/12/16
AK Scientific
Product number
4904CU
Product name
Bis-PEG3-acid
Packaging
1g
Price
$431
Updated
2021/12/16
BroadPharm
Product number
BP-20584
Product name
Bis-PEG3-acid
Purity
98%
Packaging
250mg
Price
$125
Updated
2021/12/16
Apolloscientific
Product number
BIPG1248
Product name
Bis-PEG3-acid
Packaging
250mg
Price
$468
Updated
2021/12/16
Crysdot
Product number
CD13000320
Product name
3,3'-((Oxybis(ethane-2,1-diyl))bis(oxy))dipropanoicacid
Purity
97%
Packaging
1g
Price
$520
Updated
2021/12/16
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Bis-PEG4-acid Chemical Properties,Usage,Production

Description

Bis-PEG3-acid is a PEG linker containing two terminal carboxylic acid groups. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acids can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Uses

Bis-PEG3-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] Zhao Q, et al. Discovery of SIAIS178 as an Effective BCR-ABL Degrader by Recruiting Von Hippel-Lindau (VHL) E3 Ubiquitin Ligase. J Med Chem. 2019 Oct 24;62(20):9281-9298. DOI:10.1021/acs.jmedchem.9b01264

Bis-PEG4-acid Preparation Products And Raw materials

Raw materials

Preparation Products

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Bis-PEG4-acid Suppliers

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Innochem(Beijing) Technology Co.,Ltd.
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View Lastest Price from Bis-PEG4-acid manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
Bis-PEG3-acid 96517-92-9
Price
US $0.00/g
Min. Order
10g
Purity
>98.00%
Supply Ability
10g
Release date
2024-03-23

96517-92-9, Bis-PEG4-acidRelated Search:

Bis-Propargyl-PEG4 HO-PEG8-CH2CH2COOH Maleimide-PEG2-NHS Ester PEG5-acid HOOC-PEG7-CH2CH2COOH alpha, oMega-Dipropionic acid triethylene glycol α,ω-dipropionic acid tetraethylene glycol Bis-PEG2-acid Bis-PEG6-acid α,ω,-dipropionic acid nonaethylene glycol alpha-(2-Carboxyethyl)-omega-(2-carboxyethoxy)poly(oxy-1,2-ethanediyl) Bis-PEG4-t-butyl ester Bis-PEG10-acid alpha, oMega-Dipropionic acid hexaethylene glycol Bis-PEG6-t-butyl ester Bis-PEG1-NHS ester Bis-PEG5-t-butyl ester Bis-PEG9-t-butyl ester

  • Bis-PEG3-COOH
  • 3,3'-[oxybis(ethane-2,1-diyloxy)]dipropanoic acid
  • Bis-PEG3-acid
  • 3,3'-((Oxybis(ethane-2,1-diyl))bis(oxy))dipropanoic acid
  • COOH-PEG2-COOH
  • 4,7,10-trioxa-tridecanedioic acid
  • HOOCCH2CH2O-PEG2-CH2CH2COOH
  • Propanoic acid, 3,3'-[oxybis(2,1-ethanediyloxy)]bis-
  • Di-Acid-PEG3
  • 3,3'-((oxybis(ethane-2,1-diyl))bis(oxy))dipropionic acid
  • HOOCCH2CH2O-PEG2-CH2CH2COOH/4,7,10-Trioxatridecanedioic acid
  • 3-[2-[2-(2-carboxyethoxy)ethoxy]ethoxy]propanoic acid
  • Bis-PEG3-acid ，S1350
  • 96517-92-9