Azide-PEG3-Desthiobiotin

Product Name: Azide-PEG3-Desthiobiotin
CAS No.: 1426828-06-9
Chemical Name: Azide-PEG3-Desthiobiotin
Synonyms: CAS_1426828-06-9;Desthiobiotin-PEG4-Azide;Azide-PEG3-Desthiobiotin;N-[2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethyl]-6-[(4R,5S)-5-methyl-2-oxoimidazolidin-4-yl]hexanamide
CBNumber: CB73369446
Molecular Formula: C18H34N6O5
Formula Weight: 414.51
MOL File: 1426828-06-9.mol

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Azide-PEG3-Desthiobiotin Property

storage temp.: Storage temp. 2-8°C
form: clear liquid
color: Colorless to Yellow to Orange

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Safety

HS Code: 2933.29.9000

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TCI Chemical

Product number: A3202
Product name: Azide-PEG3-Desthiobiotin
Packaging: 10MG
Price: $337
Updated: 2025/07/31

BroadPharm

Product number: BP-22473
Product name: Desthiobiotin-PEG3-Azide
Purity: 95%
Packaging: 25mg
Price: $329
Updated: 2021/12/16

BroadPharm

Product number: BP-22473
Product name: Desthiobiotin-PEG3-Azide
Purity: 95%
Packaging: 250mg
Price: $2180
Updated: 2021/12/16

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Azide-PEG3-Desthiobiotin Chemical Properties,Usage,Production

Description

Desthiobiotin is a single-ring, sulfur-free analog of biotin that binds to streptavidin with nearly equal specificity but less affinity than biotin (Kd?= 1011?vs. 1015M, respectively). Consequently, desthiobiotinylated proteins can be eluted readily and specifically from streptavidin affinity resin using mild conditions based on competitive displacement with free biotin. For pull-down experiments with biological samples, this soft-release characteristic of desthiobiotin also helps to minimize co-purification of endogenous biotinylated molecules, which remain bound to streptavidin upon elution of the target protein complexes with free biotin.

Uses

Azide-PEG3-Desthiobiotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azide-PEG3-Desthiobiotin is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Azide-PEG3-Desthiobiotin Preparation Products And Raw materials

Raw materials

Preparation Products

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Azide-PEG3-Desthiobiotin Suppliers

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View Lastest Price from Azide-PEG3-Desthiobiotin manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Desthiobiotin-PEG3-Azide 1426828-06-9
Price: US $0.00/g
Min. Order: 5g
Purity: >98.00%
Supply Ability: 5g
Release date: 2024-03-30

Xian confluore Biological Technology Co., Ltd.

Product: Desthiobiotin-PEG3-Azide 1426828-06-9
Price: US $0.00/g
Min. Order: 1g
Purity: >98.00%
Supply Ability: 1g
Release date: 2024-03-30

1426828-06-9, Azide-PEG3-DesthiobiotinRelated Search:

N-Biotinyl-N'-(3-maleimidopropionyl)-3,6-dioxaoctane-1,8-diamine BIOTIN HPDP DESTHIOBIOTIN N-HYDROXYSUCCINIMIDYL ESTER biotinylamidoethylacetamide SULPHOSUCCINIMIDYL-6-(BIOTINAMIDO)HEXANOATE (+)-BIOTIN-EPSILON-AMINOCAPROIC ACID Succinimidyl 6-(biotinamido)hexanoate D-DESTHIOBIOTIN BIOTIN-4-FLUORESCEIN Azido-PEG3-aldehyde Ald-PEG3-Azide Azido-PEG16-t-butyl ester Desthiobiotin-PEG3-Amine Azido-PEG6-CH2COOH Azido-PEG16-acid Azido-PEG3-Tos Azido-PEG15-azide Azido-PEG15-alcohol

Azide-PEG3-Desthiobiotin

N-[2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethyl]-6-[(4R,5S)-5-methyl-2-oxoimidazolidin-4-yl]hexanamide

CAS_1426828-06-9

Desthiobiotin-PEG4-Azide

1426828-06-9