ChemicalBook > CAS DataBase List > (2-AMINO-PYRIDIN-4-YL)-METHANOL

(2-AMINO-PYRIDIN-4-YL)-METHANOL

Product Name
(2-AMINO-PYRIDIN-4-YL)-METHANOL
CAS No.
105250-17-7
Chemical Name
(2-AMINO-PYRIDIN-4-YL)-METHANOL
Synonyms
2-aMinopyridin-4-Methanol;2-AMINOPYRIDINE-4-METHANOL;2-AMINO-4-PYRIDINEMETHANOL;2-Amino-4-pyridinylmethanol;4-Pyridinemethanol, 2-amino-;2-Aminopyridine-4-methanol,97%;2-Amino-4-hydroxymethylpyridine;(2-AMINO-PYRIDIN-4-YL)-METHANOL;4-Pyridinemethanol,2-amino-(9CI);2-AMino-4-hyddroxyMethylpyridine
CBNumber
CB7349960
Molecular Formula
C6H8N2O
Formula Weight
124.14
MOL File
105250-17-7.mol
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(2-AMINO-PYRIDIN-4-YL)-METHANOL Property

Melting point:
43-44°C
Boiling point:
329.5±27.0 °C(Predicted)
Density 
1.257±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
pka
13.37±0.10(Predicted)
form 
Crystalline Powder
color 
White to yellow
Water Solubility 
Soluble in water.
Sensitive 
Air Sensitive
BRN 
8760550
InChI
InChI=1S/C6H8N2O/c7-6-3-5(4-9)1-2-8-6/h1-3,9H,4H2,(H2,7,8)
InChIKey
ZRJJXXDQIQFZBW-UHFFFAOYSA-N
SMILES
C1(N)=NC=CC(CO)=C1
CAS DataBase Reference
105250-17-7(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-22
Safety Statements 
26-36
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
714577
Product name
2-Amino-4-pyridinylmethanol
Purity
97%
Packaging
1g
Price
$54.28
Updated
2025/07/31
TCI Chemical
Product number
A3249
Product name
2-Amino-4-pyridinylmethanol
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$33
Updated
2025/07/31
TCI Chemical
Product number
A3249
Product name
2-Amino-4-pyridinylmethanol
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$129
Updated
2025/07/31
TRC
Product number
A629063
Product name
(2-Aminopyridin-4-yl)methanol
Packaging
100mg
Price
$75
Updated
2021/12/16
Apolloscientific
Product number
OR40456
Product name
2-Amino-4-(hydroxymethyl)pyridine
Purity
98%
Packaging
250mg
Price
$17
Updated
2021/12/16
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(2-AMINO-PYRIDIN-4-YL)-METHANOL Chemical Properties,Usage,Production

Chemical Properties

Light yellow Cryst

Uses

2-Aminopyridine-4-methanol is used as pharmaceutical intermediate.

Synthesis Reference(s)

Journal of Medicinal Chemistry, 44, p. 78, 2001 DOI: 10.1021/jm001034k

Synthesis

6937-03-7

105250-17-7

General procedure for the synthesis of 2-amino-4-pyridinemethanol from methyl 2-aminoisonicotinate: 26 g of lithium aluminum hydride was dissolved in 800 mL of anhydrous tetrahydrofuran (THF). Under stirring conditions, 103 g of 2-aminoisonicotinic acid methyl ester dissolved in 600 mL of anhydrous THF was slowly added, and the resulting slurry was heated to reflux for 3 hours. Upon completion of the reaction, the reaction was quenched by careful addition of cooling water, and the precipitate was collected by filtration and washed with 300 mL of THF. The filtrates were combined and concentrated under reduced pressure and the residue was recrystallized from benzene. The product was obtained as 61 g in 73% yield with a melting point of 80-81.5°C. The product was analyzed by 1H NMR (DMSO-d6, δ, ppm): 4.36 (s, 2H), 5.19 (s, 1H), 5.78 (s, 2H), 6.40 (d, 1H), 6.46 (s, 1H), 7.81 (d, 1H).13C NMR (DMSO- d6, δ, ppm): 62.3, 105.2, 110.3, 147.7, 152.7, 160.3. Elemental analysis results (%): C 57.63, H 6.32, N 22.68; theoretical values (C6H8N2O): C 58.05, H 6.40, N 22.56.

References

[1] Russian Journal of Organic Chemistry, 2015, vol. 51, # 5, p. 744 - 745
[2] Zh. Org. Khim., 2015, vol. 51, # 5, p. 759 - 760,2
[3] Patent: EP3018125, 2016, A1. Location in patent: Paragraph 0515-0516; 0519-0520
[4] Patent: US2003/100567, 2003, A1
[5] Patent: US2002/147203, 2002, A1

(2-AMINO-PYRIDIN-4-YL)-METHANOL Preparation Products And Raw materials

Raw materials

Acetic anhydride Acetone Triethylamine Lithium Aluminum Hydride Potassium permanganate Sodium hydroxide 4-Methylpyridin-2-amine

Preparation Products

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(2-AMINO-PYRIDIN-4-YL)-METHANOL Suppliers

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View Lastest Price from (2-AMINO-PYRIDIN-4-YL)-METHANOL manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
(2-AMINO-PYRIDIN-4-YL)-METHANOL 105250-17-7
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-04-30
Shaanxi Dideu Medichem Co. Ltd
Product
(2-AMINO-PYRIDIN-4-YL)-METHANOL 105250-17-7
Min. Order
1KG
Purity
99.0% min
Supply Ability
100 tons
Release date
2021-04-15
Career Henan Chemical Co
Product
2-AMINO-PYRIDIN-4-YL)-METHANOL 105250-17-7
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
Judy@coreychem.com
Release date
2019-12-18

105250-17-7, (2-AMINO-PYRIDIN-4-YL)-METHANOLRelated Search:

2-Aminoisonicotinic acid 4-(AMINOPYRIDINE-3-YL) METHANOL (2-AMINO-PYRIDIN-3-YL)-METHANOL,(2-Amino-pyridin-3-yl)-methanol ,97%,(2-AMINO-PYRIDIN-3-YL)-METHANOL (6-AMINO-PYRIDIN-3-YL)-METHANOL (3-AMINO-PYRIDIN-2-YL)-METHANOL Methyl 2-aminopyridine-4-carboxylate Ethyl 2-Aminoisonicotinate 2-MORPHOLIN-4-YL-ISONICOTINIC ACID 2-ACETYLAMINO-ISONICOTINIC ACID (3-AMINO-PYRIDIN-4-YL)-METHANOL 2-(2,2,2-TRIMETHYLACETAMIDO)PYRIDINE-3-METHANOL (4-AMINO-PYRIDIN-3-YL)-METHANOL 2-Aminopyridine (2-AMINO-PYRIDIN-4-YL)-METHANOL 2-(2,2-DIMETHYL-PROPIONYLAMINO)-ISONICOTINIC ACID METHYL ESTER 2-(Dimethylamino)-6-methyl-4-pyridinecarboxylicacid 2-(4-MORPHOLINYL)-PYRIDINE-4-CARBOXYLIC ACID METHYL ESTER 2-PIPERAZIN-1-YL-QUINOLINE-4-CARBOXYLIC ACID 4-Quinolinecarboxylic acid, 2-((2,4-dimethylphenyl)amino)-

  • 2-AMINO-4-PYRIDINEMETHANOL
  • (2-AMINO-PYRIDIN-4-YL)-METHANOL
  • 2-AMINOPYRIDINE-4-METHANOL
  • 2-Amino-4-hydroxymethylpyridine
  • 4-Pyridinemethanol,2-amino-(9CI)
  • 2-Amino-4-pyridinylmethanol
  • (2-Amino-pyridin-4-yl)-methanol ,97%
  • (2-amino-4-pyridinyl)methanol(SALTDATA: FREE)
  • 2-aMinopyridin-4-Methanol
  • 4-(Hydroxymethyl)pyridin-2-amine, (2-Aminopyridin-4-yl)methanol
  • 2-AMino-4-hyddroxyMethylpyridine
  • (2-AMinopyrid-4-yl)Methanol, 97%
  • 2-Aminopyridine-4-methanol,97%
  • 4-Pyridinemethanol, 2-amino-
  • (2-AMINO-PYRIDIN-4-YL)-METHANOL ISO 9001：2015 REACH
  • 105250-17-7
  • PYRIDINE
  • pharmacetical
  • Pyridine series